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    PAQR6 progestin and adipoQ receptor family member 6 [ Homo sapiens (human) ]

    Gene ID: 79957, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PAQR6provided by HGNC
    Official Full Name
    progestin and adipoQ receptor family member 6provided by HGNC
    Primary source
    HGNC:HGNC:30132
    See related
    Ensembl:ENSG00000160781 MIM:614579; AllianceGenome:HGNC:30132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRdelta
    Summary
    Predicted to enable signaling receptor activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 24.4), skin (RPKM 3.1) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PAQR6 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156243320..156248056, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155381777..155386513, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156213111..156217847, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1856 Neighboring gene PMF1-BGLAP readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1422 Neighboring gene polyamine modulated factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1857 Neighboring gene BGLAP promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1424 Neighboring gene Sharpr-MPRA regulatory region 3040 Neighboring gene bone gamma-carboxyglutamate protein Neighboring gene SMG5 nonsense mediated mRNA decay factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156250697-156251670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1425 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:156252643-156253614 Neighboring gene transmembrane protein 79 Neighboring gene Sharpr-MPRA regulatory regions 9834 and 13552 Neighboring gene glycosylated lysosomal membrane protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PAQR6 Upregulation Is Associated with AR Signaling and Unfavorite Prognosis in Prostate Cancers. Yang M, et al. Biomolecules, 2021 Sep 18. PMID 34572596, Free PMC Article
    2. Characterization, neurosteroid binding and brain distribution of human membrane progesterone receptors δ and {epsilon} (mPRδ and mPR{epsilon}) and mPRδ involvement in neurosteroid inhibition of apoptosis. Pang Y, et al. Endocrinology, 2013 Jan. PMID 23161870, Free PMC Article
    3. Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors. Smith JL, et al. Steroids, 2008 Oct. PMID 18603275, Free PMC Article
    4. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. Huang X, et al. Mol Endocrinol, 2013 Sep. PMID 23864651, Free PMC Article
    5. Identification of genes related to Parkinson's disease using expressed sequence tags. Kim JM, et al. DNA Res, 2006 Dec 31. PMID 17213182

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAQR6 Upregulation Is Associated with AR Signaling and Unfavorite Prognosis in Prostate Cancers.
      Title: PAQR6 Upregulation Is Associated with AR Signaling and Unfavorite Prognosis in Prostate Cancers.
    2. The results suggest that PAQR6 and PAQR9 (mPRdelta and mPRepsilon) function as mPRs coupled to G proteins and are potential intermediaries of nonclassical antiapoptotic actions of neurosteroids in the central nervous system.
      Title: Characterization, neurosteroid binding and brain distribution of human membrane progesterone receptors δ and {epsilon} (mPRδ and mPR{epsilon}) and mPRδ involvement in neurosteroid inhibition of apoptosis.
    3. PAQR6 is a previously uncharacterized PAQR which is also capable of responding to progesterone.
      Title: Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22672

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane progestin receptor delta
    Names
    mPR delta
    membrane progesterone P4 receptor delta
    membrane progesterone receptor delta
    progesterone and adipoQ receptor family member 6
    progestin and adipoQ receptor family member VI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272104.2 → NP_001259033.1  membrane progestin receptor delta isoform 2

      See identical proteins and their annotated locations for NP_001259033.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses alternate splice sites at internal exons and initiates translation at an alternate start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has distinct N- and C-termini and is shorter, compared to isoform 1.
      Source sequence(s)
      AA310453, AF455047, AK095197, AK294143, AL135927, BP217276
      Consensus CDS
      CCDS1136.1
      UniProtKB/Swiss-Prot
      B7Z9R9, D3DVB4, D3DVB6, Q5TCK9, Q6PDU0, Q6TCH4, Q7Z4Q7, Q7Z4Q9, Q8N121, Q8N3M2, Q9H621
      UniProtKB/TrEMBL
      Q5TCK7, Q5TCK8
      Conserved Domains (1) summary
      pfam03006
      Location:43 → 272
      HlyIII; Haemolysin-III related

    2. NM_001272105.2 → NP_001259034.1  membrane progestin receptor delta isoform 3

      See identical proteins and their annotated locations for NP_001259034.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, uses alternate splice sites in the coding region and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (3) has distinct N- and C-termini and is shorter, compared to isoform 1.
      Source sequence(s)
      AA310453, AF455047, AK316034, AL135927, DT218672
      Consensus CDS
      CCDS60301.1
      UniProtKB/TrEMBL
      Q5TCK8
      Related
      ENSP00000349474.3, ENST00000356983.7
      Conserved Domains (1) summary
      pfam03006
      Location:40 → 269
      HlyIII; Haemolysin-III related

    3. NM_001272106.2 → NP_001259035.1  membrane progestin receptor delta isoform 4

      See identical proteins and their annotated locations for NP_001259035.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AA310453, AK295916, AL135927
      Consensus CDS
      CCDS72946.1
      UniProtKB/TrEMBL
      B4DJ42
      Related
      ENSP00000482685.1, ENST00000612424.4

    4. NM_001272107.2 → NP_001259036.1  membrane progestin receptor delta isoform 5

      See identical proteins and their annotated locations for NP_001259036.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site at an internal exon in the 3' coding region, compared to variant 1. It encodes isoform 5 which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA310453, AF455045, AF455047, AL135927, BP217276
      UniProtKB/TrEMBL
      K9J969
      Related
      ENST00000468632.5
      Conserved Domains (1) summary
      cl03831
      Location:1 → 166
      HlyIII; Haemolysin-III related

    5. NM_001272108.2 → NP_001259037.1  membrane progestin receptor delta isoform 6

      See identical proteins and their annotated locations for NP_001259037.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (6) has distinct N- and C-termini and is shorter, compared to isoform 1.
      Source sequence(s)
      AA310453, AF455047, AL135927, BP208594, BP217276
      UniProtKB/Swiss-Prot
      Q6TCH4
      Conserved Domains (1) summary
      cl03831
      Location:59 → 161
      HlyIII; Haemolysin-III related

    6. NM_001272109.2 → NP_001259038.1  membrane progestin receptor delta isoform 7

      See identical proteins and their annotated locations for NP_001259038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. Variants 8 through 12 encode the same isoform (7), which has a distinct N-terminus and is shorter, compared to isoform 1.
      Source sequence(s)
      AA310453, AF455046, AF455047, AK316034, AL135927
      Consensus CDS
      CCDS72945.1
      UniProtKB/TrEMBL
      A0A9K3Y7B0, D3DVB5, Q7Z4Q8
      Related
      ENSP00000485607.1, ENST00000623241.3

    7. NM_001272110.2 → NP_001259039.1  membrane progestin receptor delta isoform 7

      See identical proteins and their annotated locations for NP_001259039.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. Variants 8 through 12 encode the same isoform (7), which has a distinct N-terminus and is shorter, compared to isoform 1.
      Source sequence(s)
      AA310453, AF455047, AK054682, AL135927
      Consensus CDS
      CCDS72945.1
      UniProtKB/TrEMBL
      A0A9K3Y7B0, D3DVB5, Q7Z4Q8

    8. NM_001272111.2 → NP_001259040.1  membrane progestin receptor delta isoform 7

      See identical proteins and their annotated locations for NP_001259040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. Variants 8 through 12 encode the same isoform (7), which has a distinct N-terminus and is shorter, compared to isoform 1.
      Source sequence(s)
      AA310453, AF455047, AL135927, BI551776, BP208594
      Consensus CDS
      CCDS72945.1
      UniProtKB/TrEMBL
      A0A9K3Y7B0, D3DVB5, Q7Z4Q8

    9. NM_001272112.2 → NP_001259041.1  membrane progestin receptor delta isoform 7

      See identical proteins and their annotated locations for NP_001259041.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. Variants 8 through 12 encode the same isoform (7), which has a distinct N-terminus and is shorter, compared to isoform 1.
      Source sequence(s)
      AA310453, AF455046, AK295916, AK316034, AL135927, BI819919
      Consensus CDS
      CCDS72945.1
      UniProtKB/TrEMBL
      A0A9K3Y7B0, D3DVB5, Q7Z4Q8
      Related
      ENSP00000443167.2, ENST00000540423.5

    10. NM_001272113.2 → NP_001259042.1  membrane progestin receptor delta isoform 7

      See identical proteins and their annotated locations for NP_001259042.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) has multiple differences and initiates translation at an alternate start codon, compared to variant 1. Variants 8 through 12 encode the same isoform (7), which has a distinct N-terminus and is shorter, compared to isoform 1.
      Source sequence(s)
      AA310453, AF455047, AL135927, BP217276, BP362806
      Consensus CDS
      CCDS72945.1
      UniProtKB/TrEMBL
      A0A9K3Y7B0, D3DVB5, Q7Z4Q8
      Related
      ENSP00000479864.1, ENST00000613336.4

    11. NM_024897.4 → NP_079173.2  membrane progestin receptor delta isoform 1

      See identical proteins and their annotated locations for NP_079173.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA310453, AK095197, AK295916, AL135927, BP217276
      Consensus CDS
      CCDS1135.1
      UniProtKB/Swiss-Prot
      Q6TCH4
      UniProtKB/TrEMBL
      B4DJ42
      Related
      ENSP00000338330.1, ENST00000335852.6
      Conserved Domains (1) summary
      cl03831
      Location:1 → 150
      HlyIII; Haemolysin-III related

    12. NM_198406.3 → NP_940798.1  membrane progestin receptor delta isoform 2

      See identical proteins and their annotated locations for NP_940798.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has distinct N- and C-termini and is shorter, compared to isoform 1.
      Source sequence(s)
      AA310453, AF455047, AK026325, AL135927, BC058509, BP217276
      Consensus CDS
      CCDS1136.1
      UniProtKB/Swiss-Prot
      B7Z9R9, D3DVB4, D3DVB6, Q5TCK9, Q6PDU0, Q6TCH4, Q7Z4Q7, Q7Z4Q9, Q8N121, Q8N3M2, Q9H621
      UniProtKB/TrEMBL
      Q5TCK7, Q5TCK8
      Related
      ENSP00000292291.5, ENST00000292291.10
      Conserved Domains (1) summary
      pfam03006
      Location:43 → 272
      HlyIII; Haemolysin-III related

    RNA

    1. NR_073610.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) uses multiple alternate splice sites, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA310453, AF455047, AL135927, BC058509, BP217276
      Related
      ENST00000368270.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156243320..156248056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155381777..155386513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TCH4.2 GenPept UniProtKB/Swiss-Prot:Q6TCH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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