Slc16a2 solute carrier family 16 (monocarboxylic acid transporters), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc16a2provided by MGI
Official Full Name: solute carrier family 16 (monocarboxylic acid transporters), member 2provided by MGI
Primary source: MGI:MGI:1203732
See related: Ensembl:ENSMUSG00000033965 AllianceGenome:MGI:1203732
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mct8; Xpct
Summary: Enables thyroid hormone transmembrane transporter activity. Involved in thyroid hormone transport. Acts upstream of or within with a negative effect on thyroid hormone generation and thyroid-stimulating hormone secretion. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; cochlea; and limb. Used to study Allan-Herndon-Dudley syndrome. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome and intellectual disability. Orthologous to human SLC16A2 (solute carrier family 16 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in kidney adult (RPKM 54.4), liver adult (RPKM 41.5) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: X D; X 46.29 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (102741020..102865594, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (103697414..103821988, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice.
Title: Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice.
Cone photoreceptor differentiation regulated by thyroid hormone transporter MCT8 in the retinal pigment epithelium.
Title: Cone photoreceptor differentiation regulated by thyroid hormone transporter MCT8 in the retinal pigment epithelium.
Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome.
Title: Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome.
The Differential Effect of a Shortage of Thyroid Hormone Compared with Knockout of Thyroid Hormone Transporters Mct8 and Mct10 on Murine Macrophage Polarization.
Title: The Differential Effect of a Shortage of Thyroid Hormone Compared with Knockout of Thyroid Hormone Transporters Mct8 and Mct10 on Murine Macrophage Polarization.
Neurovascular unit disruption and blood-brain barrier leakage in MCT8 deficiency.
Title: Neurovascular unit disruption and blood-brain barrier leakage in MCT8 deficiency.
Thyroid hormone transporter Mct8/Oatp1c1 deficiency compromises proper oligodendrocyte maturation in the mouse CNS.
Title: Thyroid hormone transporter Mct8/Oatp1c1 deficiency compromises proper oligodendrocyte maturation in the mouse CNS.
A CRISPR/Cas9-engineered avatar mouse model of monocarboxylate transporter 8 deficiency displays distinct neurological alterations.
Title: A CRISPR/Cas9-engineered avatar mouse model of monocarboxylate transporter 8 deficiency displays distinct neurological alterations.
Bone cell-specific deletion of thyroid hormone transporter Mct8 distinctly regulates bone volume in young versus adult male mice.
Title: Bone cell-specific deletion of thyroid hormone transporter Mct8 distinctly regulates bone volume in young versus adult male mice.
Brain Gene Expression in Systemic Hypothyroidism and Mouse Models of MCT8 Deficiency: The Mct8-Oatp1c1-Dio2 Triad.
Title: Brain Gene Expression in Systemic Hypothyroidism and Mouse Models of MCT8 Deficiency: The Mct8-Oatp1c1-Dio2 Triad.
Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
Title: Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (6) 1 citation

General gene information

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Markers

Slc16a2 (e-PCR), detects polymorphism
- UniSTS:144413

AW105741 (e-PCR)
- UniSTS:181317

px-71b1 (e-PCR)
- UniSTS:258159

Slc16a2 (e-PCR), detects polymorphism
- UniSTS:526752

Slc16a2 (e-PCR), detects polymorphism
- UniSTS:547315

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables thyroid hormone transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyroid hormone transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables thyroid hormone transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thyroid hormone transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in amino acid import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of amino acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hormone transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect thyroid hormone generation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_negative_effect thyroid hormone generation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of thyroid hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thyroid hormone transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within thyroid hormone transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within thyroid hormone transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_negative_effect thyroid-stimulating hormone secretion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_negative_effect thyroid-stimulating hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transport across blood-brain barrier	IEA Inferred from Electronic Annotation more info
involved_in transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: monocarboxylate transporter 8

Names: MCT 8; Monocarboxylate transporter 8 (MCT 8) (X-linked PEST-containing transporter); X-linked PEST-containing transporter; solute carrier family 16 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009197.2 → NP_033223.2 monocarboxylate transporter 8

See identical proteins and their annotated locations for NP_033223.2

Status: VALIDATED

Source sequence(s)

BC080678, BM935188, CJ177309, CX218841

Consensus CDS

CCDS30330.1

UniProtKB/Swiss-Prot

O70324, Q8K3S9

UniProtKB/TrEMBL

Q05BA2

Related

ENSMUSP00000037629.6, ENSMUST00000042664.10

Conserved Domains (1) summary

cl26868
Location:92 → 519

2A0111; oxalate/formate antiporter family transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

102741020..102865594 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251272.2 → XP_030107132.1 monocarboxylate transporter 8 isoform X1

UniProtKB/TrEMBL

Q8K3S7

Conserved Domains (1) summary

cl28910
Location:32 → 386

MFS; Major Facilitator Superfamily