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    Or4e5 olfactory receptor family 4 subfamily E member 5 [ Mus musculus (house mouse) ]

    Gene ID: 57269, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Or4e5provided by MGI
    Official Full Name
    olfactory receptor family 4 subfamily E member 5provided by MGI
    Primary source
    MGI:MGI:3031341
    See related
    Ensembl:ENSMUSG00000059887 AllianceGenome:MGI:3031341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Or28; Mor28; MOR244-1; Olfr1507
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
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    Genomic context

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    See Or4e5 in Genome Data Viewer
    Location:
    14 C2; 14 26.97 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52727392..52733152, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52489935..52495695, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily E member 2 Neighboring gene T cell receptor alpha chain Neighboring gene predicted gene, 36382 Neighboring gene olfactory receptor family 4 subfamily E member 1 Neighboring gene enolase 1, alpha non-neuron pseudogene Neighboring gene predicted gene, 36448 Neighboring gene ATPase, H+ transporting, lysosomal accessory protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Monoallelic expression of the odourant receptor gene and axonal projection of olfactory sensory neurones. Ishii T, et al. Genes Cells, 2001 Jan. PMID 11277098
    2. Odorant receptors on axon termini in the brain. Barnea G, et al. Science, 2004 Jun 4. PMID 15178793
    3. RNA-mediated symmetry breaking enables singular olfactory receptor choice. Pourmorady AD, et al. Nature, 2024 Jan. PMID 38123679, Free PMC Article
    4. Neuropilin-2 is required for the proper targeting of ventral glomeruli in the mouse olfactory bulb. Takahashi H, et al. Mol Cell Neurosci, 2010 Jul. PMID 20363325
    5. Dnmt3a regulates global gene expression in olfactory sensory neurons and enables odorant-induced transcription. Colquitt BM, et al. Neuron, 2014 Aug 20. PMID 25123312, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identifed an upstream cis-acting DNA region that activates the OR gene cluster in mouse and allows the expression of only one OR gene within the cluster
      Title: Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse.
    2. localized to the axon terminus in the olfactory bulb
      Title: Odorant receptors on axon termini in the brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (6)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    olfactory receptor 1507
    Names
    GA_x6K02T2RJGY-491851-492792
    gene for odorant receptor MOR28
    olfactory receptor MOR244-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007044.1 

      Range
      62469..68229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170918.1 → NP_001164389.1  olfactory receptor 1507

      See identical proteins and their annotated locations for NP_001164389.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC119165, CB173597, CB174012
      Consensus CDS
      CCDS27062.1
      UniProtKB/TrEMBL
      A0A0U1RPW5, F7C854, Q0VEP0, Q9R0K5
      Related
      ENSMUSP00000146152.4, ENSMUST00000206062.4
      Conserved Domains (2) summary
      pfam00001
      Location:44 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34 → 308
      7tm_4; Olfactory receptor

    2. NM_020512.2 → NP_065258.2  olfactory receptor 1507

      See identical proteins and their annotated locations for NP_065258.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC119165
      Consensus CDS
      CCDS27062.1
      UniProtKB/TrEMBL
      A0A0U1RPW5, F7C854, Q0VEP0, Q9R0K5
      Related
      ENSMUSP00000073260.6, ENSMUST00000073571.6
      Conserved Domains (2) summary
      pfam00001
      Location:44 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34 → 308
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      52727392..52733152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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