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    Kitl kit ligand [ Mus musculus (house mouse) ]

    Gene ID: 17311, updated on 4-Jan-2025

    Summary

    Official Symbol
    Kitlprovided by MGI
    Official Full Name
    kit ligandprovided by MGI
    Primary source
    MGI:MGI:96974
    See related
    Ensembl:ENSMUSG00000019966 AllianceGenome:MGI:96974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted
    Summary
    Enables cytokine activity and stem cell factor receptor binding activity. Acts upstream of or within several processes, including positive regulation of cell differentiation; positive regulation of cell population proliferation; and positive regulation of protein phosphorylation. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Waardenburg syndrome; autosomal dominant nonsyndromic deafness 69; familial progressive hyperpigmentation with or without hypopigmentation; and pigmentation disease. Orthologous to human KITLG (KIT ligand). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in lung adult (RPKM 2.7), CNS E18 (RPKM 2.6) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Kitl in Genome Data Viewer
    Location:
    10 D1; 10 51.4 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (99851477..99936278)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (100015615..100100416)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35437 Neighboring gene keratin 18 pseudogene Neighboring gene STARR-seq mESC enhancer starr_27731 Neighboring gene STARR-seq mESC enhancer starr_27732 Neighboring gene predicted gene, 35533 Neighboring gene STARR-seq mESC enhancer starr_27733 Neighboring gene STARR-seq mESC enhancer starr_27734 Neighboring gene THO complex 4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity PubMed 
    enables growth factor activity  
    enables protein binding PubMed 
    enables stem cell factor receptor binding  
    enables stem cell factor receptor binding PubMed 
    Items 1 - 25 of 41
    Process Evidence Code Pubs
    acts_upstream_of Ras protein signal transduction PubMed 
    acts_upstream_of T cell proliferation PubMed 
    acts_upstream_of apoptotic process PubMed 
    involved_in cell adhesion  
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of_or_within ectopic germ cell programmed cell death PubMed 
    involved_in embryonic hemopoiesis  
    involved_in embryonic hemopoiesis  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand PubMed 
    acts_upstream_of_or_within germ cell development PubMed 
    acts_upstream_of hematopoietic progenitor cell differentiation PubMed 
    involved_in male gonad development  
    acts_upstream_of mast cell apoptotic process PubMed 
    acts_upstream_of mast cell migration PubMed 
    acts_upstream_of mast cell proliferation PubMed 
    acts_upstream_of mast cell proliferation PubMed 
    acts_upstream_of_or_within melanocyte migration PubMed 
    acts_upstream_of myeloid leukocyte differentiation PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of mast cell apoptotic process PubMed 
    acts_upstream_of_or_within neural crest cell migration PubMed 
    involved_in ovarian follicle development  
    involved_in ovarian follicle development  
    acts_upstream_of peptidyl-tyrosine phosphorylation PubMed 
    acts_upstream_of_or_within positive regulation of MAP kinase activity PubMed 
    acts_upstream_of_or_within positive regulation of Ras protein signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of T cell proliferation PubMed 
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of leukocyte migration PubMed 
    acts_upstream_of_or_within positive regulation of mast cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of mast cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of melanocyte differentiation PubMed 
    acts_upstream_of_or_within positive regulation of myeloid leukocyte differentiation PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in response to organic cyclic compound  
    Items 1 - 25 of 41
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in extracellular region  
    located_in extracellular space PubMed 
    located_in filopodium  
    located_in filopodium  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    kit ligand
    Names
    C-kit ligand
    Steel factor
    cloud gray
    grizzle-belly
    hematopoietic growth factor KL
    mast cell growth factor
    stem cell factor
    NP_001334085.1
    NP_038626.1
    XP_006513377.1
    XP_006513378.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347156.2NP_001334085.1  kit ligand isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct internal amino acid and is shorter than isoform 1.
      Source sequence(s)
      AC159910
      Consensus CDS
      CCDS83751.1
      UniProtKB/Swiss-Prot
      P20826
      Related
      ENSMUSP00000020129.8, ENSMUST00000020129.8
    2. NM_001428623.1NP_001415552.1  kit ligand isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159910
    3. NM_001428627.1NP_001415556.1  kit ligand isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC159910
    4. NM_013598.4NP_038626.1  kit ligand isoform 1 precursor

      See identical proteins and their annotated locations for NP_038626.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC159910
      Consensus CDS
      CCDS36046.1
      UniProtKB/Swiss-Prot
      P20826, P97332, Q3TNJ7, Q62524, Q64222, Q921N5
      Related
      ENSMUSP00000100920.2, ENSMUST00000105283.9
      Conserved Domains (1) summary
      pfam02404
      Location:1273
      SCF; Stem cell factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      99851477..99936278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513314.5XP_006513377.1  kit ligand isoform X1

      Conserved Domains (1) summary
      pfam02404
      Location:46313
      SCF; Stem cell factor
    2. XM_006513315.4XP_006513378.1  kit ligand isoform X2

      Conserved Domains (1) summary
      pfam02404
      Location:46285
      SCF; Stem cell factor
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