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    Pdgfra platelet derived growth factor receptor, alpha polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 18595, updated on 14-Jan-2025

    Summary

    Official Symbol
    Pdgfraprovided by MGI
    Official Full Name
    platelet derived growth factor receptor, alpha polypeptideprovided by MGI
    Primary source
    MGI:MGI:97530
    See related
    Ensembl:ENSMUSG00000029231 AllianceGenome:MGI:97530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD140a; Pdgfr-2
    Summary
    This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]
    Expression
    Broad expression in limb E14.5 (RPKM 29.6), lung adult (RPKM 20.2) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Pdgfra in Genome Data Viewer
    Location:
    5 C3.3; 5 39.55 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (75311988..75358867)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (75151322..75198206)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19583 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, pseudogene Neighboring gene olfactory receptor 1401, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E8936 Neighboring gene STARR-seq mESC enhancer starr_13421 Neighboring gene microRNA 7025 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 pseudogene Neighboring gene sterol O-acyltransferase 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 38
    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables phosphatidylinositol 3-kinase binding  
    enables phospholipase C activator activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor alpha-receptor activity PubMed 
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables platelet-derived growth factor binding  
    enables platelet-derived growth factor binding PubMed 
    enables platelet-derived growth factor binding  
    enables platelet-derived growth factor binding PubMed 
    enables platelet-derived growth factor receptor binding  
    enables platelet-derived growth factor receptor binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase activity PubMed 
    enables protein tyrosine kinase collagen receptor activity  
    enables protein-containing complex binding PubMed 
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor binding  
    enables vascular endothelial growth factor binding  
    enables vascular endothelial growth factor receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 38
    Items 1 - 25 of 80
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    acts_upstream_of_or_within Leydig cell differentiation PubMed 
    acts_upstream_of_or_within adrenal gland development PubMed 
    acts_upstream_of_or_within anatomical structure morphogenesis PubMed 
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cardiac myofibril assembly PubMed 
    involved_in cell chemotaxis PubMed 
    involved_in cell chemotaxis  
    involved_in cell migration PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    acts_upstream_of_or_within cellular response to amino acid stimulus PubMed 
    acts_upstream_of_or_within cellular response to reactive oxygen species PubMed 
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in embryonic cranial skeleton morphogenesis  
    involved_in embryonic cranial skeleton morphogenesis PubMed 
    involved_in embryonic digestive tract morphogenesis PubMed 
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    acts_upstream_of_or_within estrogen metabolic process PubMed 
    acts_upstream_of_or_within extracellular matrix organization PubMed 
    acts_upstream_of_or_within face morphogenesis PubMed 
    acts_upstream_of_or_within female gonad development PubMed 
    involved_in fibroblast growth factor receptor signaling pathway  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway  
    acts_upstream_of_or_within in utero embryonic development PubMed 
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    acts_upstream_of_or_within lung development PubMed 
    involved_in lung growth  
    acts_upstream_of_or_within luteinization PubMed 
    acts_upstream_of_or_within luteinization PubMed 
    involved_in macrophage colony-stimulating factor signaling pathway  
    acts_upstream_of_or_within male genitalia development PubMed 
    involved_in metanephric glomerular capillary formation PubMed 
    involved_in multicellular organism development  
    involved_in negative regulation of platelet activation  
    involved_in negative regulation of platelet activation  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth PubMed 
    involved_in peptidyl-tyrosine phosphorylation PubMed 
    involved_in peptidyl-tyrosine phosphorylation  
    involved_in peptidyl-tyrosine phosphorylation  
    involved_in platelet aggregation  
    involved_in platelet aggregation  
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway PubMed 
    involved_in platelet-derived growth factor receptor signaling pathway  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway PubMed 
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of branching involved in lung morphogenesis  
    involved_in positive regulation of calcium-mediated signaling  
    involved_in positive regulation of calcium-mediated signaling  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  
    involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  
    involved_in positive regulation of chemotaxis  
    involved_in positive regulation of chemotaxis  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in protein autophosphorylation PubMed 
    involved_in protein autophosphorylation  
    involved_in protein autophosphorylation  
    involved_in regulation of mesenchymal stem cell differentiation  
    involved_in regulation of mesenchymal stem cell differentiation  
    involved_in retina vasculature development in camera-type eye PubMed 
    acts_upstream_of_or_within roof of mouth development PubMed 
    acts_upstream_of_or_within signal transduction involved in regulation of gene expression PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis PubMed 
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    acts_upstream_of_or_within white fat cell differentiation PubMed 
    involved_in wound healing PubMed 
    Items 1 - 25 of 80
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in axon  
    located_in cell junction  
    located_in cell junction  
    located_in cell surface PubMed 
    located_in cilium PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in external side of plasma membrane PubMed 
    located_in microvillus PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of protein-containing complex PubMed 
    part_of receptor complex  
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    platelet-derived growth factor receptor alpha
    Names
    Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)
    CD140 antigen-like family member A
    PDGF alpha chain
    PDGF-R-alpha
    PDGFR-alpha
    alpha-type platelet-derived growth factor receptor
    NP_001076785.1
    NP_001334647.1
    NP_001334648.1
    NP_035188.2
    XP_006504324.1
    XP_006504325.1
    XP_006504326.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083316.2NP_001076785.1  platelet-derived growth factor receptor alpha isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK147267, BC053036, BY628767, CD354225, CK627326
      Consensus CDS
      CCDS19351.1
      UniProtKB/Swiss-Prot
      P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3
      Related
      ENSMUSP00000127173.2, ENSMUST00000168162.5
      Conserved Domains (5) summary
      cd04972
      Location:416497
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05859
      Location:313413
      Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
      cd05861
      Location:228311
      Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
      cd05105
      Location:555956
      PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
      pfam13927
      Location:28100
      Ig_3; Immunoglobulin domain
    2. NM_001347718.1NP_001334647.1  platelet-derived growth factor receptor alpha isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and its 3' terminal exon extends past a splice site that is used in variant 1, which results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2, also known as 'In-PDGFRalpha') is shorter and has a distinct C-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AC120348, AK081664, AK147267
      Consensus CDS
      CCDS89929.1
      UniProtKB/Swiss-Prot
      P26618
      Related
      ENSMUSP00000143906.2, ENSMUST00000202681.4
    3. NM_001347719.1NP_001334648.1  platelet-derived growth factor receptor alpha isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and its 3' terminal exon extends past a splice site that is used in variant 1, which results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2, also known as 'In-PDGFRalpha') is shorter and has a distinct C-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AC120348, AK081664, AK147267
      Consensus CDS
      CCDS89929.1
      UniProtKB/Swiss-Prot
      P26618
      Related
      ENSMUSP00000143891.2, ENSMUST00000201711.4
    4. NM_011058.3NP_035188.2  platelet-derived growth factor receptor alpha isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC120348, AK147267, BY628767, CK627326
      Consensus CDS
      CCDS19351.1
      UniProtKB/Swiss-Prot
      P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3
      Related
      ENSMUSP00000000476.9, ENSMUST00000000476.15
      Conserved Domains (5) summary
      cd04972
      Location:416497
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05859
      Location:313413
      Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
      cd05861
      Location:228311
      Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
      cd05105
      Location:555956
      PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
      pfam13927
      Location:28100
      Ig_3; Immunoglobulin domain

    RNA

    1. NR_144636.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) includes a 3' terminal exon that extends past a splice site that is used in variant 1. This variant is represented as non-coding because it lacks a stop codon, rendering the transcript a candidate for non-stop decay.
      Source sequence(s)
      AC120348, AK139094, AK147267
      Related
      ENSMUST00000202186.4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      75311988..75358867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504263.5XP_006504326.1  platelet-derived growth factor receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3
      Conserved Domains (5) summary
      cd04972
      Location:416497
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05859
      Location:313413
      Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
      cd05861
      Location:228311
      Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
      cd05105
      Location:555956
      PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
      pfam13927
      Location:28100
      Ig_3; Immunoglobulin domain
    2. XM_006504261.5XP_006504324.1  platelet-derived growth factor receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3
      Conserved Domains (5) summary
      cd04972
      Location:416497
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05859
      Location:313413
      Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
      cd05861
      Location:228311
      Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
      cd05105
      Location:555956
      PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
      pfam13927
      Location:28100
      Ig_3; Immunoglobulin domain
    3. XM_006504262.5XP_006504325.1  platelet-derived growth factor receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      P26618, Q3TQ37, Q62046, Q7TSJ3, Q8C4N3
      Conserved Domains (5) summary
      cd04972
      Location:416497
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05859
      Location:313413
      Ig4_PDGFR; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
      cd05861
      Location:228311
      Ig_PDGFR-alphabeta; Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
      cd05105
      Location:555956
      PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
      pfam13927
      Location:28100
      Ig_3; Immunoglobulin domain
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