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    Qpct glutaminyl-peptide cyclotransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313837, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Qpctprovided by RGD
    Official Full Name
    glutaminyl-peptide cyclotransferaseprovided by RGD
    Primary source
    RGD:1562284
    See related
    EnsemblRapid:ENSRNOG00000005705 AllianceGenome:RGD:1562284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Qpctl1; RGD1562284
    Summary
    Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Predicted to be located in extracellular region. Orthologous to human QPCT (glutaminyl-peptide cyclotransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 45.6), Lung (RPKM 41.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Qpct in Genome Data Viewer
    Location:
    6q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (21716824..21748895, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (15964656..15996730, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (1657110..1689575)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene mortality factor 4 like 1, pseudogene 1 Neighboring gene ATP synthase membrane subunit G like 3 Neighboring gene ribosomal protein S17, pseudogene 9 Neighboring gene protein kinase D3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glutaminyl cyclases as novel targets for the treatment of septic arthritis. Hellvard A, et al. J Infect Dis, 2013 Mar 1. PMID 23204180, Free PMC Article
    2. Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase. Song I, et al. J Mol Endocrinol, 1994 Aug. PMID 7999256
    3. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. Huang KF, et al. J Biol Chem, 2011 Apr 8. PMID 21288892, Free PMC Article
    4. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutaminyl-peptide cyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminyl-peptide cyclotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutaminyl-peptide cyclotransferase
    Names
    glutaminyl cyclase
    glutaminyl-peptide cyclotransferase-like 1
    NP_001128029.1
    NP_001386445.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134557.3 → NP_001128029.1  glutaminyl-peptide cyclotransferase isoform 2 precursor

      See identical proteins and their annotated locations for NP_001128029.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K497, A6H9U1, A6H9U2
      Related
      ENSRNOP00000072958.1, ENSRNOT00000079864.3
      Conserved Domains (1) summary
      cd03880
      Location:41 → 310
      M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

    2. NM_001399516.1 → NP_001386445.1  glutaminyl-peptide cyclotransferase isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      D4AC85
      Related
      ENSRNOP00000045568.3, ENSRNOT00000049672.6
      Conserved Domains (1) summary
      cd03880
      Location:54 → 359
      M28_QC_like; M28 Zn-peptidase glutaminyl cyclase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      21716824..21748895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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