Ciao1 cytosolic iron-sulfur assembly component 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ciao1provided by RGD
Official Full Name: cytosolic iron-sulfur assembly component 1provided by RGD
Primary source: RGD:1307285
See related: EnsemblRapid:ENSRNOG00000012638 AllianceGenome:RGD:1307285
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wdr39
Summary: Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytoplasm. Predicted to be part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human CIAO1 (cytosolic iron-sulfur assembly component 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 162.7), Muscle (RPKM 159.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (134913639..134919244, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (114458671..114465928, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (119671778..119677324, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in iron-sulfur cluster assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein maturation by iron-sulfur cluster transfer	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by iron-sulfur cluster transfer	ISO Inferred from Sequence Orthology more info
involved_in protein maturation by iron-sulfur cluster transfer	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of MMXD complex	IEA Inferred from Electronic Annotation more info
part_of MMXD complex	ISO Inferred from Sequence Orthology more info
part_of MMXD complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of cytosolic [4Fe-4S] assembly targeting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic [4Fe-4S] assembly targeting complex	IEA Inferred from Electronic Annotation more info
part_of cytosolic [4Fe-4S] assembly targeting complex	ISO Inferred from Sequence Orthology more info
part_of cytosolic [4Fe-4S] assembly targeting complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: probable cytosolic iron-sulfur protein assembly protein CIAO1

Names: WD repeat domain 39; WD repeat-containing protein 39; WD40 protein Ciao1; cytosolic iron-sulfur protein assembly 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008766.1 → NP_001008766.1 probable cytosolic iron-sulfur protein assembly protein CIAO1

See identical proteins and their annotated locations for NP_001008766.1

Status: PROVISIONAL

Source sequence(s)

BC088474

UniProtKB/Swiss-Prot

Q5M7T1

UniProtKB/TrEMBL

A0A8L2UJ40, A6HQ07

Related

ENSRNOP00000017603.5, ENSRNOT00000017603.7

Conserved Domains (3) summary

COG2319
Location:22 → 335

WD40; WD40 repeat [General function prediction only]

cd00200
Location:17 → 332

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:19 → 58

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

134913639..134919244 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104428.2 → XP_038960356.1 probable cytosolic iron-sulfur protein assembly protein CIAO1 isoform X1

UniProtKB/TrEMBL

A0A8I6A7Q2

Related

ENSRNOP00000089224.1, ENSRNOT00000113397.2

Conserved Domains (2) summary

cd00200
Location:17 → 221

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:19 → 58

7WD40; WD40 repeat [structural motif]