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    Bbx BBX high mobility group box domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303970, updated on 2-Nov-2024

    Summary

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    Symbol
    Bbxprovided by RGD
    Full Name
    BBX high mobility group box domain containingprovided by RGD
    Primary source
    RGD:1309769
    See related
    EnsemblRapid:ENSRNOG00000001971 AllianceGenome:RGD:1309769
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone development. Predicted to be active in nucleus. Orthologous to human BBX (BBX high mobility group box domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 228.3), Adrenal (RPKM 142.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bbx in Genome Data Viewer
    Location:
    11q21
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (63850034..64097700)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (50381249..50628934)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (52983286..53228557)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134480992 Neighboring gene ribosomal protein L26, pseudogene 9 Neighboring gene uncharacterized LOC134480993 Neighboring gene uncharacterized LOC134480994

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PiggyBac Transposon-Mediated Mutagenesis in Rats Reveals a Crucial Role of Bbx in Growth and Male Fertility. Wang CY, et al. Biol Reprod, 2016 Sep. PMID 27465138, Free PMC Article
    2. Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. Bassett JH, et al. PLoS Genet, 2012. PMID 22876197, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that loss of BBX induces apoptosis of postmeiotic spermatids and results in spermiogenesis defects and infertility.
      Title: PiggyBac Transposon-Mediated Mutagenesis in Rats Reveals a Crucial Role of Bbx in Growth and Male Fertility.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HMG box transcription factor BBX
    Names
    BBX, HMG-box containing
    HMG box transcription factor BBX-like
    bobby sox homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079938.1 → NP_001073407.1  HMG box transcription factor BBX

      See identical proteins and their annotated locations for NP_001073407.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129113
      UniProtKB/TrEMBL
      A1L1L0, A6IQT5
      Related
      ENSRNOP00000002700.5, ENSRNOT00000002700.8
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 302
      DUF2028; Domain of unknown function (DUF2028)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      63850034..64097700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088363.2 → XP_038944291.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRG6, A0A8I6ADK4
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    2. XM_063270545.1 → XP_063126615.1  HMG box transcription factor BBX isoform X3

      UniProtKB/TrEMBL
      A1L1L0

    3. XM_063270541.1 → XP_063126611.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADK4

    4. XM_063270544.1 → XP_063126614.1  HMG box transcription factor BBX isoform X3

      UniProtKB/TrEMBL
      A1L1L0

    5. XM_063270557.1 → XP_063126627.1  HMG box transcription factor BBX isoform X6

    6. XM_063270552.1 → XP_063126622.1  HMG box transcription factor BBX isoform X4

    7. XM_063270558.1 → XP_063126628.1  HMG box transcription factor BBX isoform X7

      Related
      ENSRNOP00000089981.2, ENSRNOT00000119802.2

    8. XM_008768637.4 → XP_008766859.1  HMG box transcription factor BBX isoform X1

      See identical proteins and their annotated locations for XP_008766859.1

      UniProtKB/TrEMBL
      A0A8I5ZRG6, A0A8I6ADK4
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    9. XM_039088366.2 → XP_038944294.1  HMG box transcription factor BBX isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZRG6
      Conserved Domains (2) summary
      cd01388
      Location:54 → 112
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:153 → 285
      DUF2028; Domain of unknown function (DUF2028)

    10. XM_017598008.3 → XP_017453497.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRG6, A0A8I6ADK4
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    11. XM_008768634.4 → XP_008766856.1  HMG box transcription factor BBX isoform X1

      See identical proteins and their annotated locations for XP_008766856.1

      UniProtKB/TrEMBL
      A0A8I5ZRG6, A0A8I6ADK4
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    12. XM_039088365.2 → XP_038944293.1  HMG box transcription factor BBX isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRG6
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    13. XM_008768638.4 → XP_008766860.1  HMG box transcription factor BBX isoform X3

      See identical proteins and their annotated locations for XP_008766860.1

      UniProtKB/TrEMBL
      A1L1L0, A6IQT5
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 302
      DUF2028; Domain of unknown function (DUF2028)

    14. XM_008768641.4 → XP_008766863.1  HMG box transcription factor BBX isoform X5

      UniProtKB/TrEMBL
      A0A0G2JXW5, A6IQT5
      Related
      ENSRNOP00000070428.2, ENSRNOT00000083438.3
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam09667
      Location:191 → 302
      DUF2028; Domain of unknown function (DUF2028)

    15. XM_008768640.4 → XP_008766862.1  HMG box transcription factor BBX isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZRG6
      Conserved Domains (2) summary
      cd01388
      Location:54 → 112
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:153 → 285
      DUF2028; Domain of unknown function (DUF2028)

    16. XM_063270535.1 → XP_063126605.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADK4

    17. XM_063270536.1 → XP_063126606.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADK4

    18. XM_063270553.1 → XP_063126623.1  HMG box transcription factor BBX isoform X4

    19. XM_063270537.1 → XP_063126607.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADK4

    20. XM_017598001.3 → XP_017453490.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRG6, A0A8I6ADK4
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    21. XM_063270549.1 → XP_063126619.1  HMG box transcription factor BBX isoform X4

    22. XM_063270539.1 → XP_063126609.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADK4

    23. XM_017598004.3 → XP_017453493.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRG6, A0A8I6ADK4
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    24. XM_063270550.1 → XP_063126620.1  HMG box transcription factor BBX isoform X4

    25. XM_017598002.3 → XP_017453491.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRG6, A0A8I6ADK4
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    26. XM_063270543.1 → XP_063126613.1  HMG box transcription factor BBX isoform X3

      UniProtKB/TrEMBL
      A1L1L0

    27. XM_063270551.1 → XP_063126621.1  HMG box transcription factor BBX isoform X4

    28. XM_063270538.1 → XP_063126608.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADK4

    29. XM_063270556.1 → XP_063126626.1  HMG box transcription factor BBX isoform X4

    30. XM_063270534.1 → XP_063126604.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADK4

    31. XM_017598003.3 → XP_017453492.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRG6, A0A8I6ADK4
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    32. XM_017598005.3 → XP_017453494.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRG6, A0A8I6ADK4
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    33. XM_063270554.1 → XP_063126624.1  HMG box transcription factor BBX isoform X4

    34. XM_017598007.3 → XP_017453496.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRG6, A0A8I6ADK4
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    35. XM_017598009.3 → XP_017453498.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRG6, A0A8I6ADK4
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    36. XM_063270548.1 → XP_063126618.1  HMG box transcription factor BBX isoform X3

      UniProtKB/TrEMBL
      A1L1L0

    37. XM_039088364.2 → XP_038944292.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRG6, A0A8I6ADK4
      Conserved Domains (2) summary
      cd01388
      Location:79 → 150
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam09667
      Location:191 → 323
      DUF2028; Domain of unknown function (DUF2028)

    38. XM_063270542.1 → XP_063126612.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADK4

    39. XM_063270540.1 → XP_063126610.1  HMG box transcription factor BBX isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADK4

    40. XM_063270547.1 → XP_063126617.1  HMG box transcription factor BBX isoform X3

      UniProtKB/TrEMBL
      A1L1L0

    41. XM_063270546.1 → XP_063126616.1  HMG box transcription factor BBX isoform X3

      UniProtKB/TrEMBL
      A1L1L0

    42. XM_063270555.1 → XP_063126625.1  HMG box transcription factor BBX isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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