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    Dpysl4 dihydropyrimidinase-like 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25417, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dpysl4provided by RGD
    Official Full Name
    dihydropyrimidinase-like 4provided by RGD
    Primary source
    RGD:2409
    See related
    EnsemblRapid:ENSRNOG00000027582 AllianceGenome:RGD:2409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crmp3; Dpys4
    Summary
    Predicted to enable filamin binding activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; and phosphoprotein binding activity. Involved in neuron development. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human DPYSL4 (dihydropyrimidinase like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 160.0), Testes (RPKM 16.0) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Dpysl4 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (203312646..203328523)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (193883039..193898916)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (211423022..211438533)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553541 Neighboring gene janus kinase and microtubule interacting protein 3 Neighboring gene serine/threonine kinase 32C Neighboring gene uncharacterized LOC120099954 Neighboring gene leucine rich repeat containing 27

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables dihydropyrimidinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables filamin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables filamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in neuron development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    NOT involved_in pyrimidine nucleobase catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    dihydropyrimidinase-related protein 4
    Names
    CRMP-3
    Collapsin response mediator protein 3
    DRP-4
    ULIP-4
    ULIP4 protein
    UNC33-like phosphoprotein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012933.2NP_037065.1  dihydropyrimidinase-related protein 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q62951
      UniProtKB/TrEMBL
      F1LNT0
      Related
      ENSRNOP00000029334.3, ENSRNOT00000029587.4
      Conserved Domains (2) summary
      PRK09060
      Location:17467
      PRK09060; dihydroorotase; Validated
      cd01314
      Location:17466
      D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      203312646..203328523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101695.1XP_038957623.1  dihydropyrimidinase-related protein 4 isoform X1

      Conserved Domains (1) summary
      cl00281
      Location:69375
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...