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    Rps5 ribosomal protein S5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25538, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rps5provided by RGD
    Official Full Name
    ribosomal protein S5provided by RGD
    Primary source
    RGD:3601
    See related
    EnsemblRapid:ENSRNOG00000019453 AllianceGenome:RGD:3601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA binding activity and rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in regulation of translational fidelity; ribosomal small subunit assembly; and translation. Part of cytosolic small ribosomal subunit. Orthologous to human RPS5 (ribosomal protein S5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 3706.9), Thymus (RPKM 2969.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rps5 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (82610965..82615262)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (73538776..73543073)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (65660470..65664767, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 22 Neighboring gene uncharacterized LOC134482891 Neighboring gene ring finger protein 225 Neighboring gene uncharacterized LOC134482890

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis. Xu WH, et al. Hepatology, 2014 Aug. PMID 24668691
    2. The primary structure of rat ribosomal protein S5. A ribosomal protein present in the rat genome in a single copy. Kuwano Y, et al. J Biol Chem, 1992 Dec 15. PMID 1460027
    3. Expression of ribosomal protein S5 cloned gene during differentiation and apoptosis in murine erythroleukemia (MEL) cells. Vizirianakis IS, et al. Oncol Res, 1999. PMID 10821535
    4. Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5. Galkin O, et al. RNA, 2007 Dec. PMID 17901157, Free PMC Article
    5. Electron microscopic investigations on the location of rat liver ribosomal proteins S3a, S5, S6, S7 and S9 by means of antibody labeling. Lutsch G, et al. Biomed Biochim Acta, 1983. PMID 6196023

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results demonstrate that RPS5 is implicated in hepatic fibrogenesis.
      Title: Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of translational fidelity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS7
    Names
    40S ribosomal protein S5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277243.1 → NP_001264172.1  small ribosomal subunit protein uS7 isoform 1

      See identical proteins and their annotated locations for NP_001264172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      FM052146, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P24050
      UniProtKB/TrEMBL
      B0BN81, F7FP79
      Related
      ENSRNOP00000026528.4, ENSRNOT00000026528.9
      Conserved Domains (1) summary
      cd14867
      Location:18 → 204
      uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7

    2. NM_001277244.1 → NP_001264173.1  small ribosomal subunit protein uS7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      FM052146, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P24050
      Related
      ENSRNOP00000072051.3, ENSRNOT00000088367.3
      Conserved Domains (1) summary
      cd14867
      Location:18 → 171
      uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      82610965..82615262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105722.1: Suppressed sequence

      Description
      NM_001105722.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24050.3 GenPept UniProtKB/Swiss-Prot:P24050

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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