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    CD300LF CD300 molecule like family member f [ Homo sapiens (human) ]

    Gene ID: 146722, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CD300LFprovided by HGNC
    Official Full Name
    CD300 molecule like family member fprovided by HGNC
    Primary source
    HGNC:HGNC:29883
    See related
    Ensembl:ENSG00000186074 MIM:609807; AllianceGenome:HGNC:29883
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLM1; NKIR; CLM-1; IREM1; LMIR3; CD300f; IREM-1; IgSF13
    Summary
    This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Expression
    Biased expression in spleen (RPKM 9.3), bone marrow (RPKM 8.2) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CD300LF in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74694317..74712923, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75585036..75603637, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72690456..72709062, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928343 Neighboring gene CD300e molecule Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:72627822-72628322 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:72628323-72628823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12714 Neighboring gene uncharacterized LOC105371894 Neighboring gene RAB37, member RAS oncogene family Neighboring gene uncharacterized LOC124904057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72733027-72733750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72734475-72735197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12717 Neighboring gene SLC9A3R1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72743321-72743916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8939 Neighboring gene microRNA 3615 Neighboring gene NHERF family PDZ scaffold protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CD300f signalling induces inhibitory human monocytes/macrophages. Sutherland SIM, et al. Cell Immunol, 2023 Aug. PMID 37302321
    2. The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase. Alvarez-Errico D, et al. J Immunol, 2007 Jan 15. PMID 17202342
    3. Overexpression of the immunoreceptor CD300f has a neuroprotective role in a model of acute brain injury. Peluffo H, et al. Brain Pathol, 2012 May. PMID 21951326, Free PMC Article
    4. CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness. Lago N, et al. Proc Natl Acad Sci U S A, 2020 Mar 24. PMID 32152116, Free PMC Article
    5. Immune receptor expressed on myeloid cells 1 (IREM-1) inhibits B cell activation factor (BAFF)-mediated inflammatory regulation of THP-1 cells through modulation of the activities of extracellular regulated kinase (ERK). Lee SM, et al. Clin Exp Immunol, 2010 Sep. PMID 20646006, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD300f signalling induces inhibitory human monocytes/macrophages.
      Title: CD300f signalling induces inhibitory human monocytes/macrophages.
    2. CD300a and CD300f molecules regulate the function of leukocytes.
      Title: CD300a and CD300f molecules regulate the function of leukocytes.
    3. Differential Lipid Recognition by Mouse versus Human CD300f, Inhibiting Passive Cutaneous Anaphylaxis, Depends on a Single Amino Acid Substitution in its Immunoglobulin-Like Domain.
      Title: Differential Lipid Recognition by Mouse versus Human CD300f, Inhibiting Passive Cutaneous Anaphylaxis, Depends on a Single Amino Acid Substitution in its Immunoglobulin-Like Domain.
    4. Single-nucleotide polymorphism in CD300f gene is associated with major depressive disorder.
      Title: CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness.
    5. ceramide-CD300f interaction inhibits neutrophil recruitment to the sites of Gram-negative bacterial skin infections in mice.
      Title: Role of the Ceramide-CD300f Interaction in Gram-Negative Bacterial Skin Infections.
    6. this study demonstrates the role of CD300f in governing innate immune eosinophil activities in pediatric Crohn's disease patients and in active ulcerative colitis patients
      Title: A key requirement for CD300f in innate immune responses of eosinophils in colitis.
    7. findings suggest that two rare heterozygous truncating variations (RPS24 Q191X and CD300LF P261fsX266) are risk candidates for autism spectrum disorder.
      Title: Rare heterozygous truncating variations and risk of autism spectrum disorder: Whole-exome sequencing of a multiplex family and follow-up study in a Japanese population.
    8. CD300 molecules are all expressed by DC; CD300b, d, e and f are restricted to different subpopulations of the myeloid DC lineage. They have been shown to regulate DC function both in vitro and in vivo.
      Title: CD300 molecule regulation of human dendritic cell functions.
    9. The data suggest that the neuroprotective role of CD300f would be the result of a complex network of cell interactions.
      Title: Overexpression of the immunoreceptor CD300f has a neuroprotective role in a model of acute brain injury.
    10. peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling
      Title: Synthetic peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling through activation of SHP and/or PI3K.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
    EBI GWAS Catalog
    Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ceramide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables interleukin-4 receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylserine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRIF-dependent toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response-activating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-13-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic cell clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of mast cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic cell clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interleukin-4-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    CMRF35-like molecule 1
    Names
    CD300 antigen-like family member F
    NK inhibitory receptor
    immune receptor expressed on myeloid cells 1
    immunoglobin superfamily member 13
    immunoglobulin superfamily member 13
    inhibitory receptor IREM1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289082.2 → NP_001276011.1  CMRF35-like molecule 1 isoform 2

      See identical proteins and their annotated locations for NP_001276011.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as sv3) differs in its 5' UTR, uses an alternate start codon, and lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      BC028199, BM680508, BM923728, DA673169
      Consensus CDS
      CCDS74148.1
      UniProtKB/Swiss-Prot
      Q8TDQ1
      Related
      ENSP00000463743.1, ENST00000469092.5
      Conserved Domains (2) summary
      cd05716
      Location:30 → 128
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:28 → 128
      IG_like; Immunoglobulin like

    2. NM_001289083.2 → NP_001276012.1  CMRF35-like molecule 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001276012.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an alternate exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK092757, BI911496, BM680508, BM923728, BP226373
      Consensus CDS
      CCDS74151.1
      UniProtKB/Swiss-Prot
      Q8TDQ1
      Related
      ENSP00000301573.9, ENST00000301573.13
      Conserved Domains (2) summary
      cd05716
      Location:27 → 125
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:25 → 125
      IG_like; Immunoglobulin like

    3. NM_001289084.2 → NP_001276013.1  CMRF35-like molecule 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (4) is longer, compared to isoform 1.
      Source sequence(s)
      AK298752, BI911496, BM680508, BM923728
      Consensus CDS
      CCDS74152.1
      UniProtKB/TrEMBL
      B4DQD2, J3KS52
      Related
      ENSP00000462309.1, ENST00000583937.5
      Conserved Domains (3) summary
      cd05716
      Location:27 → 125
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:25 → 125
      IG_like; Immunoglobulin like
      pfam15330
      Location:193 → 274
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    4. NM_001289085.2 → NP_001276014.1  CMRF35-like molecule 1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as sv1) differs in its 5' UTR, and uses an alternate start codon, compared to variant 1. The encoded isoform (5) has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF375480, BC028199, BI911496, BM680508, BM923728
      Consensus CDS
      CCDS74149.1
      UniProtKB/TrEMBL
      B4DQD2
      Conserved Domains (3) summary
      cd05716
      Location:30 → 128
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:28 → 128
      IG_like; Immunoglobulin like
      pfam15330
      Location:181 → 262
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    5. NM_001289086.2 → NP_001276015.1  CMRF35-like molecule 1 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in its 5' UTR, uses an alternate start codon, and lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (6) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      BC028199, BI911496, BM680508, BM923728, DQ153249
      Consensus CDS
      CCDS74150.1
      UniProtKB/Swiss-Prot
      Q8TDQ1
      Related
      ENSP00000355294.4, ENST00000361254.8
      Conserved Domains (2) summary
      cd05716
      Location:30 → 128
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:28 → 128
      IG_like; Immunoglobulin like

    6. NM_001289087.2 → NP_001276016.1  CMRF35-like molecule 1 isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an exon in the central coding region, which results in a frameshift, compared to variant (1). The encoded isoform (7) has a shorter and distinct C-terminus, compared to variant 1.
      Source sequence(s)
      BC028199, BI911496, BM680508, BM922663, BM923728
      UniProtKB/Swiss-Prot
      Q8TDQ1
      Conserved Domains (2) summary
      cd05716
      Location:27 → 125
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:25 → 125
      IG_like; Immunoglobulin like

    7. NM_139018.5 → NP_620587.2  CMRF35-like molecule 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_620587.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AY358545, BM680508, BM923728, DA673169
      Consensus CDS
      CCDS11704.1
      UniProtKB/Swiss-Prot
      B2RCL2, C9JDN3, Q3Y6P0, Q6UX24, Q7Z6A6, Q7Z7I4, Q7Z7I5, Q8N6D0, Q8NAF5, Q8TDQ1
      UniProtKB/TrEMBL
      B4DQD2
      Related
      ENSP00000327075.6, ENST00000326165.11
      Conserved Domains (3) summary
      cd05716
      Location:27 → 125
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:25 → 125
      IG_like; Immunoglobulin like
      pfam15330
      Location:178 → 259
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    RNA

    1. NR_110298.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as sv2) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF375481, BC028199, BI911496, BM680508, BM923728

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      74694317..74712923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435413.1 → XP_047291369.1  CMRF35-like molecule 1 isoform X7

      UniProtKB/TrEMBL
      B4DQD2

    2. XM_047435411.1 → XP_047291367.1  CMRF35-like molecule 1 isoform X5

      UniProtKB/TrEMBL
      B4DQD2

    3. XM_017024212.3 → XP_016879701.1  CMRF35-like molecule 1 isoform X10

      UniProtKB/TrEMBL
      B4DQD2

    4. XM_047435408.1 → XP_047291364.1  CMRF35-like molecule 1 isoform X2

      UniProtKB/TrEMBL
      B4DQD2

    5. XM_047435417.1 → XP_047291373.1  CMRF35-like molecule 1 isoform X11

      UniProtKB/TrEMBL
      B4DQD2
      Related
      ENSP00000464257.1, ENST00000464910.5

    6. XM_047435415.1 → XP_047291371.1  CMRF35-like molecule 1 isoform X8

      UniProtKB/TrEMBL
      B4DQD2

    7. XM_047435412.1 → XP_047291368.1  CMRF35-like molecule 1 isoform X6

      UniProtKB/TrEMBL
      B4DQD2

    8. XM_047435410.1 → XP_047291366.1  CMRF35-like molecule 1 isoform X4

      UniProtKB/TrEMBL
      B4DQD2

    9. XM_047435416.1 → XP_047291372.1  CMRF35-like molecule 1 isoform X9

      UniProtKB/TrEMBL
      B4DQD2

    10. XM_047435409.1 → XP_047291365.1  CMRF35-like molecule 1 isoform X3

      UniProtKB/TrEMBL
      B4DQD2

    11. XM_047435407.1 → XP_047291363.1  CMRF35-like molecule 1 isoform X1

      UniProtKB/TrEMBL
      B4DQD2

    12. XM_047435422.1 → XP_047291378.1  CMRF35-like molecule 1 isoform X16

    13. XM_047435421.1 → XP_047291377.1  CMRF35-like molecule 1 isoform X15

      Related
      ENSP00000464610.1, ENST00000581500.1

    14. XM_047435420.1 → XP_047291376.1  CMRF35-like molecule 1 isoform X14

    15. XM_047435418.1 → XP_047291374.1  CMRF35-like molecule 1 isoform X12

    16. XM_047435419.1 → XP_047291375.1  CMRF35-like molecule 1 isoform X13

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      75585036..75603637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315139.1 → XP_054171114.1  CMRF35-like molecule 1 isoform X7

      UniProtKB/TrEMBL
      B4DQD2

    2. XM_054315137.1 → XP_054171112.1  CMRF35-like molecule 1 isoform X5

      UniProtKB/TrEMBL
      B4DQD2

    3. XM_054315142.1 → XP_054171117.1  CMRF35-like molecule 1 isoform X10

      UniProtKB/TrEMBL
      B4DQD2

    4. XM_054315134.1 → XP_054171109.1  CMRF35-like molecule 1 isoform X2

      UniProtKB/TrEMBL
      B4DQD2

    5. XM_054315143.1 → XP_054171118.1  CMRF35-like molecule 1 isoform X11

      UniProtKB/TrEMBL
      B4DQD2

    6. XM_054315140.1 → XP_054171115.1  CMRF35-like molecule 1 isoform X8

      UniProtKB/TrEMBL
      B4DQD2

    7. XM_054315138.1 → XP_054171113.1  CMRF35-like molecule 1 isoform X6

      UniProtKB/TrEMBL
      B4DQD2

    8. XM_054315136.1 → XP_054171111.1  CMRF35-like molecule 1 isoform X4

      UniProtKB/TrEMBL
      B4DQD2

    9. XM_054315141.1 → XP_054171116.1  CMRF35-like molecule 1 isoform X9

      UniProtKB/TrEMBL
      B4DQD2

    10. XM_054315135.1 → XP_054171110.1  CMRF35-like molecule 1 isoform X3

      UniProtKB/TrEMBL
      B4DQD2

    11. XM_054315133.1 → XP_054171108.1  CMRF35-like molecule 1 isoform X1

      UniProtKB/TrEMBL
      B4DQD2

    12. XM_054315148.1 → XP_054171123.1  CMRF35-like molecule 1 isoform X16

    13. XM_054315147.1 → XP_054171122.1  CMRF35-like molecule 1 isoform X15

    14. XM_054315146.1 → XP_054171121.1  CMRF35-like molecule 1 isoform X14

    15. XM_054315144.1 → XP_054171119.1  CMRF35-like molecule 1 isoform X12

    16. XM_054315145.1 → XP_054171120.1  CMRF35-like molecule 1 isoform X13

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDQ1.3 GenPept UniProtKB/Swiss-Prot:Q8TDQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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