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    TNRC6C trinucleotide repeat containing adaptor 6C [ Homo sapiens (human) ]

    Gene ID: 57690, updated on 4-Jan-2025

    Summary

    Official Symbol
    TNRC6Cprovided by HGNC
    Official Full Name
    trinucleotide repeat containing adaptor 6Cprovided by HGNC
    Primary source
    HGNC:HGNC:29318
    See related
    Ensembl:ENSG00000078687 MIM:610741; AllianceGenome:HGNC:29318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable RNA binding activity. Involved in miRNA-mediated post-transcriptional gene silencing; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in brain (RPKM 4.2), testis (RPKM 3.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TNRC6C in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (77957557..78108835)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (78851592..79002521)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (75953639..76104916)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr17:75916395-75916599 Neighboring gene uncharacterized LOC105371909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75925764-75926709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75927682-75928293 Neighboring gene RNA, U1 small nuclear 80, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr17:75931085-75931586 Neighboring gene NANOG hESC enhancer GRCh37_chr17:75944811-75945341 Neighboring gene MPRA-validated peak3014 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9037 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:75954602-75955161 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:75955162-75955720 Neighboring gene RNA, U6 small nuclear 625, pseudogene Neighboring gene ubiquitin conjugating enzyme E2 V2 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12854 Neighboring gene CEB72 minisatellite repeat instability region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12857 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76129823-76130348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76130349-76130874 Neighboring gene transmembrane channel like 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76133293-76133934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76135219-76135858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9045 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:76137495-76138694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76144923-76145422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76147835-76148412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76148413-76148989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12868 Neighboring gene transmembrane channel like 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76154005-76154506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12869 Neighboring gene chromosome 17 open reading frame 99 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (22 hits/1268 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ20015, KIAA1582

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in P-body  
    located_in cytosol  
    is_active_in nucleoplasm  

    General protein information

    Preferred Names
    trinucleotide repeat-containing gene 6C protein
    Names
    trinucleotide repeat containing 6C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142640.2 → NP_001136112.2  trinucleotide repeat-containing gene 6C protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC015804, AC021593
      UniProtKB/Swiss-Prot
      A0A8Q3SIH5, A0A8Q3SIS0, G3XAB8, Q86UE5, Q8N3D8, Q96MU9, Q9HCJ0
      UniProtKB/TrEMBL
      A0A1B0GU24
      Related
      ENSP00000512514.1, ENST00000696270.1
      Conserved Domains (4) summary
      smart00360
      Location:1762 → 1825
      RRM; RNA recognition motif
      cd14283
      Location:1148 → 1185
      UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins
      pfam10427
      Location:1035 → 1151
      Ago_hook; Argonaute hook
      pfam12938
      Location:1227 → 1456
      M_domain; M domain of GW182
    2. NM_001395508.1 → NP_001382437.1  trinucleotide repeat-containing gene 6C protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC021593
      Consensus CDS
      CCDS45799.1
      UniProtKB/TrEMBL
      A0AAA9XYZ6
      Conserved Domains (6) summary
      cd14283
      Location:938 → 975
      UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins
      pfam10427
      Location:825 → 941
      Ago_hook; Argonaute hook
      pfam12938
      Location:1017 → 1246
      M_domain; M domain of GW182
      pfam16608
      Location:1255 → 1548
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12713
      Location:1544 → 1631
      RRM_TNRC6C; RNA recognition motif (RRM) found in vertebrate trinucleotide repeat-containing gene 6C protein (TNRC6C)
      NF033849
      Location:258 → 420
      ser_rich_anae_1; serine-rich protein
    3. NM_001395509.1 → NP_001382438.1  trinucleotide repeat-containing gene 6C protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC015804, AC021593
      UniProtKB/TrEMBL
      A0A1B0GU24
      Conserved Domains (4) summary
      smart00360
      Location:1731 → 1794
      RRM; RNA recognition motif
      cd14283
      Location:1148 → 1185
      UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins
      pfam10427
      Location:1035 → 1151
      Ago_hook; Argonaute hook
      pfam12938
      Location:1236 → 1464
      M_domain; M domain of GW182
    4. NM_001395510.1 → NP_001382439.1  trinucleotide repeat-containing gene 6C protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC015804, AC021593
      Consensus CDS
      CCDS92403.1
      UniProtKB/TrEMBL
      A0A1B0GU24
      Related
      ENSP00000512702.1, ENST00000696541.1
      Conserved Domains (4) summary
      smart00360
      Location:1723 → 1786
      RRM; RNA recognition motif
      cd14283
      Location:1148 → 1185
      UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins
      pfam10427
      Location:1035 → 1151
      Ago_hook; Argonaute hook
      pfam12938
      Location:1227 → 1456
      M_domain; M domain of GW182
    5. NM_001395511.1 → NP_001382440.1  trinucleotide repeat-containing gene 6C protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC021593
      UniProtKB/TrEMBL
      A0AAA9XYZ6
      Conserved Domains (4) summary
      smart00360
      Location:1560 → 1623
      RRM; RNA recognition motif
      cd14283
      Location:938 → 975
      UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins
      pfam10427
      Location:825 → 941
      Ago_hook; Argonaute hook
      pfam12938
      Location:1026 → 1254
      M_domain; M domain of GW182
    6. NM_001395512.1 → NP_001382441.1  trinucleotide repeat-containing gene 6C protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC015804, AC021593
      UniProtKB/TrEMBL
      A0AAA9XYZ6
      Conserved Domains (6) summary
      cd14283
      Location:938 → 975
      UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins
      pfam10427
      Location:825 → 941
      Ago_hook; Argonaute hook
      pfam12938
      Location:1017 → 1246
      M_domain; M domain of GW182
      pfam16608
      Location:1255 → 1509
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12713
      Location:1505 → 1592
      RRM_TNRC6C; RNA recognition motif (RRM) found in vertebrate trinucleotide repeat-containing gene 6C protein (TNRC6C)
      NF033849
      Location:258 → 420
      ser_rich_anae_1; serine-rich protein
    7. NM_018996.3 → NP_061869.2  trinucleotide repeat-containing gene 6C protein isoform 2

      See identical proteins and their annotated locations for NP_061869.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but lacks a 3 amino acid segment near the N-terminus and a 39 amino acid segment near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AB046802, AC021593, AI337097, DA339992, DV080590
      UniProtKB/TrEMBL
      A0AAA9XYZ6
      Related
      ENSP00000468647.2, ENST00000588061.6
      Conserved Domains (5) summary
      cd12713
      Location:1513 → 1595
      RRM_TNRC6C; RNA recognition motif in vertebrate trinucleotide repeat-containing gene 6C protein (TNRC6C)
      cd14283
      Location:941 → 978
      UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins
      pfam10427
      Location:822 → 938
      Ago_hook; Argonaute hook
      pfam12938
      Location:1020 → 1248
      M_domain; M domain of GW182
      pfam16608
      Location:1258 → 1512
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      77957557..78108835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436496.1 → XP_047292452.1  trinucleotide repeat-containing gene 6C protein isoform X14

      UniProtKB/TrEMBL
      A0AAA9XYZ6
    2. XM_047436485.1 → XP_047292441.1  trinucleotide repeat-containing gene 6C protein isoform X1

      UniProtKB/TrEMBL
      A0A1B0GU24
    3. XM_006721996.5 → XP_006722059.4  trinucleotide repeat-containing gene 6C protein isoform X3

      UniProtKB/TrEMBL
      A0A1B0GU24
    4. XM_047436487.1 → XP_047292443.1  trinucleotide repeat-containing gene 6C protein isoform X4

      UniProtKB/TrEMBL
      A0A1B0GU24
    5. XM_006721997.5 → XP_006722060.4  trinucleotide repeat-containing gene 6C protein isoform X6

      UniProtKB/TrEMBL
      A0A1B0GU24
    6. XM_047436490.1 → XP_047292446.1  trinucleotide repeat-containing gene 6C protein isoform X8

      UniProtKB/TrEMBL
      A0A1B0GU24
    7. XM_047436492.1 → XP_047292448.1  trinucleotide repeat-containing gene 6C protein isoform X10

      UniProtKB/TrEMBL
      A0A1B0GU24
    8. XM_047436494.1 → XP_047292450.1  trinucleotide repeat-containing gene 6C protein isoform X12

      UniProtKB/TrEMBL
      A0A1B0GU24
    9. XM_047436486.1 → XP_047292442.1  trinucleotide repeat-containing gene 6C protein isoform X2

      UniProtKB/TrEMBL
      A0A1B0GU24
    10. XM_047436488.1 → XP_047292444.1  trinucleotide repeat-containing gene 6C protein isoform X5

      UniProtKB/TrEMBL
      A0A1B0GU24
    11. XM_047436489.1 → XP_047292445.1  trinucleotide repeat-containing gene 6C protein isoform X7

      UniProtKB/TrEMBL
      A0A1B0GU24
    12. XM_047436491.1 → XP_047292447.1  trinucleotide repeat-containing gene 6C protein isoform X9

      UniProtKB/TrEMBL
      A0A1B0GU24
    13. XM_047436493.1 → XP_047292449.1  trinucleotide repeat-containing gene 6C protein isoform X11

      UniProtKB/TrEMBL
      A0A1B0GU24
    14. XM_047436495.1 → XP_047292451.1  trinucleotide repeat-containing gene 6C protein isoform X13

      UniProtKB/TrEMBL
      A0A1B0GU24

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      78851592..79002521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316816.1 → XP_054172791.1  trinucleotide repeat-containing gene 6C protein isoform X14

      UniProtKB/TrEMBL
      A0AAA9XYZ6
    2. XM_054316803.1 → XP_054172778.1  trinucleotide repeat-containing gene 6C protein isoform X1

      UniProtKB/TrEMBL
      A0A1B0GU24
    3. XM_054316805.1 → XP_054172780.1  trinucleotide repeat-containing gene 6C protein isoform X3

      UniProtKB/TrEMBL
      A0A1B0GU24
    4. XM_054316806.1 → XP_054172781.1  trinucleotide repeat-containing gene 6C protein isoform X4

      UniProtKB/TrEMBL
      A0A1B0GU24
    5. XM_054316808.1 → XP_054172783.1  trinucleotide repeat-containing gene 6C protein isoform X6

      UniProtKB/TrEMBL
      A0A1B0GU24
    6. XM_054316810.1 → XP_054172785.1  trinucleotide repeat-containing gene 6C protein isoform X8

      UniProtKB/TrEMBL
      A0A1B0GU24
    7. XM_054316812.1 → XP_054172787.1  trinucleotide repeat-containing gene 6C protein isoform X10

      UniProtKB/TrEMBL
      A0A1B0GU24
    8. XM_054316814.1 → XP_054172789.1  trinucleotide repeat-containing gene 6C protein isoform X12

      UniProtKB/TrEMBL
      A0A1B0GU24
    9. XM_054316804.1 → XP_054172779.1  trinucleotide repeat-containing gene 6C protein isoform X2

      UniProtKB/TrEMBL
      A0A1B0GU24
    10. XM_054316807.1 → XP_054172782.1  trinucleotide repeat-containing gene 6C protein isoform X5

      UniProtKB/TrEMBL
      A0A1B0GU24
    11. XM_054316809.1 → XP_054172784.1  trinucleotide repeat-containing gene 6C protein isoform X7

      UniProtKB/TrEMBL
      A0A1B0GU24
    12. XM_054316811.1 → XP_054172786.1  trinucleotide repeat-containing gene 6C protein isoform X9

      UniProtKB/TrEMBL
      A0A1B0GU24
    13. XM_054316813.1 → XP_054172788.1  trinucleotide repeat-containing gene 6C protein isoform X11

      UniProtKB/TrEMBL
      A0A1B0GU24
    14. XM_054316815.1 → XP_054172790.1  trinucleotide repeat-containing gene 6C protein isoform X13

      UniProtKB/TrEMBL
      A0A1B0GU24
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