Fkbp5 FK506 binding protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fkbp5provided by MGI
Official Full Name: FK506 binding protein 5provided by MGI
Primary source: MGI:MGI:104670
See related: Ensembl:ENSMUSG00000024222 AllianceGenome:MGI:104670
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dit1; FKBP-5; FKBP51; D17Ertd592e
Summary: Predicted to enable heat shock protein binding activity; peptidyl-prolyl cis-trans isomerase activity; and protein-macromolecule adaptor activity. Acts upstream of or within response to bacterium. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; integumental system; and reproductive system. Human ortholog(s) of this gene implicated in alcohol dependence; heroin dependence; and major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 58.3), genital fat pad adult (RPKM 40.8) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 14.66 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (28617727..28705123, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (28398753..28486149, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FKBP51 is involved in LPS-induced microglial activation via NF-kappaB signaling to mediate neuroinflammation.
Title: FKBP51 is involved in LPS-induced microglial activation via NF-κB signaling to mediate neuroinflammation.
Dissecting the Long-Term Effect of Stress Early in Life on FKBP5: The Role of miR-20b-5p and miR-29c-3p.
Title: Dissecting the Long-Term Effect of Stress Early in Life on FKBP5: The Role of miR-20b-5p and miR-29c-3p.
FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat Diet.
Title: FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat Diet.
FKBP5 activates mitophagy by ablating PPAR-gamma to shape a benign remyelination environment.
Title: FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment.
FKBP5 deficiency attenuates calcium oxalate kidney stone formation by suppressing cell-crystal adhesion, apoptosis and macrophage M1 polarization via inhibition of NF-kappaB signaling.
Title: FKBP5 deficiency attenuates calcium oxalate kidney stone formation by suppressing cell-crystal adhesion, apoptosis and macrophage M1 polarization via inhibition of NF-κB signaling.
Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis.
Title: Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis.
FKBP5/FKBP51 on weight watch: central FKBP5 links regulatory WIPI protein networks to autophagy and metabolic control.
Title: FKBP5/FKBP51 on weight watch: central FKBP5 links regulatory WIPI protein networks to autophagy and metabolic control.
Contribution of the co-chaperone FKBP51 in the ventromedial hypothalamus to metabolic homeostasis in male and female mice.
Title: Contribution of the co-chaperone FKBP51 in the ventromedial hypothalamus to metabolic homeostasis in male and female mice.
FKBP51 mediates resilience to inflammation-induced anxiety through regulation of glutamic acid decarboxylase 65 expression in mouse hippocampus.
Title: FKBP51 mediates resilience to inflammation-induced anxiety through regulation of glutamic acid decarboxylase 65 expression in mouse hippocampus.
The co-chaperone FKBP51 modulates HPA axis activity and age-related maladaptation of the stress system in pituitary proopiomelanocortin cells.
Title: The co-chaperone FKBP51 modulates HPA axis activity and age-related maladaptation of the stress system in pituitary proopiomelanocortin cells.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Gene trapped (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fkbp5 (e-PCR), detects polymorphism
- UniSTS:143114

D17Ertd592e (e-PCR), detects polymorphism
- UniSTS:167219

AU017039 (e-PCR)
- UniSTS:209286

U36220 (e-PCR)
- UniSTS:163583

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in response to alcohol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP5

Names: 51 kDa FK506-binding protein; 51 kDa FKBP; PPIase FKBP5; rotamase

NP_034350.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010220.4 → NP_034350.1 peptidyl-prolyl cis-trans isomerase FKBP5

See identical proteins and their annotated locations for NP_034350.1

Status: VALIDATED

Source sequence(s)

AC154912, BU613862, BY740772, CF949740

Consensus CDS

CCDS37528.1

UniProtKB/Swiss-Prot

Q64378

UniProtKB/TrEMBL

Q3TX72, Q4FJN2

Related

ENSMUSP00000078382.4, ENSMUST00000079413.11

Conserved Domains (5) summary

smart00028
Location:319 → 350

TPR; Tetratricopeptide repeats

sd00006
Location:319 → 345

TPR; TPR repeat [structural motif]

pfam00254
Location:44 → 135

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

pfam00515
Location:352 → 384

TPR_1; Tetratricopeptide repeat

pfam13414
Location:319 → 382

TPR_11; TPR repeat