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    Dusp8 dual specificity phosphatase 8 [ Mus musculus (house mouse) ]

    Gene ID: 18218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dusp8provided by MGI
    Official Full Name
    dual specificity phosphatase 8provided by MGI
    Primary source
    MGI:MGI:106626
    See related
    Ensembl:ENSMUSG00000037887 AllianceGenome:MGI:106626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nttp1; 5530400B01Rik
    Summary
    Enables phosphatase activity. Involved in dephosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; placenta; retina; and yolk sac. Orthologous to human DUSP8 (dual specificity phosphatase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 20.5), CNS E18 (RPKM 19.5) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dusp8 in Genome Data Viewer
    Location:
    7 F5; 7 87.59 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141633224..141649799, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142079487..142095907, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20498 Neighboring gene MOB kinase activator 2 Neighboring gene predicted gene, 25416 Neighboring gene predicted gene, 57785 Neighboring gene predicted gene 45417 Neighboring gene predicted gene, 32786 Neighboring gene keratin associated protein 5-26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dusp8 affects hippocampal size and behavior in mice and humans. Baumann P, et al. Sci Rep, 2019 Dec 20. PMID 31862894, Free PMC Article
    2. DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling. Liu R, et al. Circ Res, 2016 Jul 8. PMID 27225478, Free PMC Article
    3. Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans. Baumann P, et al. Brain Behav, 2021 Jan. PMID 33131190, Free PMC Article
    4. hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. Martell KJ, et al. J Neurochem, 1995 Oct. PMID 7561881
    5. A member of the MAP kinase phosphatase gene family in mouse containing a complex trinucleotide repeat in the coding region. Theodosiou AM, et al. Hum Mol Genet, 1996 May. PMID 8733137

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha.
      Title: DUSP8 induces TGF-β-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α.
    2. Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.
      Title: Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.
    3. Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
      Title: Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
    4. Mice lacking DUSP6/8 have enhanced ERK1/2 activity and resistance to diet-induced obesity.
      Title: Mice lacking DUSP6/8 have enhanced ERK1/2 activity and resistance to diet-induced obesity.
    5. Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
      Title: Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
    6. DUSP8 controls stress-induced ERK1/2 signaling in cardiac myocytes.
      Title: DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 8
    Names
    neuronal tyrosine threonine phosphatase 1
    NP_032774.1
    XP_006508572.1
    XP_011240291.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008748.3 → NP_032774.1  dual specificity protein phosphatase 8

      See identical proteins and their annotated locations for NP_032774.1

      Status: VALIDATED

      Source sequence(s)
      AL603836, BC052705, BQ043453
      Consensus CDS
      CCDS22024.1
      UniProtKB/Swiss-Prot
      O09112
      UniProtKB/TrEMBL
      Q7TSZ9
      Related
      ENSMUSP00000049414.4, ENSMUST00000039926.10
      Conserved Domains (2) summary
      cd01446
      Location:10 → 137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14645
      Location:150 → 300
      DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141633224..141649799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241989.4 → XP_011240291.1  dual specificity protein phosphatase 8 isoform X1

      See identical proteins and their annotated locations for XP_011240291.1

      UniProtKB/Swiss-Prot
      O09112
      UniProtKB/TrEMBL
      Q7TSZ9
      Conserved Domains (2) summary
      cd01446
      Location:10 → 137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14645
      Location:150 → 300
      DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8

    2. XM_006508509.5 → XP_006508572.1  dual specificity protein phosphatase 8 isoform X1

      See identical proteins and their annotated locations for XP_006508572.1

      UniProtKB/Swiss-Prot
      O09112
      UniProtKB/TrEMBL
      Q7TSZ9
      Conserved Domains (2) summary
      cd01446
      Location:10 → 137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14645
      Location:150 → 300
      DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O09112.1 GenPept UniProtKB/Swiss-Prot:O09112

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