Tmbim4 transmembrane BAX inhibitor motif containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmbim4provided by MGI
Official Full Name: transmembrane BAX inhibitor motif containing 4provided by MGI
Primary source: MGI:MGI:1915462
See related: Ensembl:ENSMUSG00000020225 AllianceGenome:MGI:1915462
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610007H07Rik
Summary: Predicted to enable calcium channel activity. Involved in locomotory behavior and negative regulation of neuron apoptotic process. Predicted to be located in Golgi stack. Predicted to be active in membrane. Orthologous to human TMBIM4 (transmembrane BAX inhibitor motif containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 273.2), genital fat pad adult (RPKM 142.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 67.94 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (120044731..120060802)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (120208826..120224897)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of BCR-mediated Ca[2+] mobilization by MIZ1-TMBIM4 safeguards IgG1[+] GC B cell-positive selection.
Title: Regulation of BCR-mediated Ca(2+) mobilization by MIZ1-TMBIM4 safeguards IgG1(+) GC B cell-positive selection.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136220 (e-PCR)
- UniSTS:210214

UniSTS:236473 (e-PCR)
- UniSTS:236473

AU022431 (e-PCR)
- UniSTS:208613

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi stack	ISO Inferred from Sequence Orthology more info
located_in Golgi stack	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein lifeguard 4

Names: Z-protein; transmembrane BAX inhibitor motif-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.