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    Jade1 jade family PHD finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 269424, updated on 9-Dec-2024

    Summary

    Official Symbol
    Jade1provided by MGI
    Official Full Name
    jade family PHD finger 1provided by MGI
    Primary source
    MGI:MGI:1925835
    See related
    Ensembl:ENSMUSG00000025764 AllianceGenome:MGI:1925835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Phf17; mKIAA1807; D530048A03Rik
    Summary
    Predicted to enable transcription coactivator activity. Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; regulation of cell growth; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Predicted to be located in several cellular components, including microtubule organizing center; nuclear speck; and plasma membrane. Predicted to be part of histone acetyltransferase complex. Is expressed in several structures, including early conceptus; embryo ectoderm; genitourinary system; head somite; and primitive streak. Orthologous to human JADE1 (jade family PHD finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 17.9), bladder adult (RPKM 5.1) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Jade1 in Genome Data Viewer
    Location:
    3 B; 3 19.88 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (41510169..41571299)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (41555734..41616864)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07488 Neighboring gene RIKEN cDNA 2400006E01 gene Neighboring gene pluripotency associated transcript 4 Neighboring gene STARR-seq mESC enhancer starr_07494 Neighboring gene uncharacterized LOC118568628 Neighboring gene sodium channel and clathrin linker 1 Neighboring gene STARR-seq mESC enhancer starr_07506 Neighboring gene STARR-seq mESC enhancer starr_07507 Neighboring gene STARR-seq mESC enhancer starr_07508 Neighboring gene STARR-seq mESC enhancer starr_07509 Neighboring gene STARR-positive B cell enhancer mm9_chr3:41546357-41546658 Neighboring gene DNA segment, Chr 3, ERATO Doi 751, expressed Neighboring gene STARR-seq mESC enhancer starr_07510

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to histone H3K14 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone H3K14 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to histone H4K12 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone H4K12 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT contributes_to histone H4K16 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to histone H4K5 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone H4K5 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to histone H4K8 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone H4K8 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein Jade-1
    Names
    Jade1 PHD finger protein
    PHD finger protein 17
    jade family PHD finger protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130184.1NP_001123656.1  protein Jade-1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AV515494, BN000281, BY060282
      Consensus CDS
      CCDS17331.1
      UniProtKB/Swiss-Prot
      Q6IE84, Q6ZPI0, Q8C7S6, Q8CFM2, Q8R362
      Related
      ENSMUSP00000026865.9, ENSMUST00000026865.15
      Conserved Domains (2) summary
      COG5141
      Location:100528
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:259369
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
    2. NM_001130185.1NP_001123657.1  protein Jade-1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AV515494, BN000281, BY146568
      Consensus CDS
      CCDS17331.1
      UniProtKB/Swiss-Prot
      Q6IE84, Q6ZPI0, Q8C7S6, Q8CFM2, Q8R362
      Related
      ENSMUSP00000127113.2, ENSMUST00000170711.8
      Conserved Domains (2) summary
      COG5141
      Location:100528
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:259369
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
    3. NM_001130186.1NP_001123658.1  protein Jade-1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AV515494, BN000281, CD563805
      Consensus CDS
      CCDS17331.1
      UniProtKB/Swiss-Prot
      Q6IE84, Q6ZPI0, Q8C7S6, Q8CFM2, Q8R362
      Related
      ENSMUSP00000131441.2, ENSMUST00000168086.7
      Conserved Domains (2) summary
      COG5141
      Location:100528
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:259369
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
    4. NM_172303.4NP_758507.3  protein Jade-1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AV515494, BN000281, CJ060622
      Consensus CDS
      CCDS17331.1
      UniProtKB/Swiss-Prot
      Q6IE84, Q6ZPI0, Q8C7S6, Q8CFM2, Q8R362
      Related
      ENSMUSP00000128152.2, ENSMUST00000163764.8
      Conserved Domains (2) summary
      COG5141
      Location:100528
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:259369
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      41510169..41571299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252630.1XP_030108490.1  protein Jade-1 isoform X1

      UniProtKB/Swiss-Prot
      Q6IE84, Q6ZPI0, Q8C7S6, Q8CFM2, Q8R362
      Conserved Domains (2) summary
      COG5141
      Location:100528
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:259369
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
    2. XM_030252631.2XP_030108491.1  protein Jade-1 isoform X1

      UniProtKB/Swiss-Prot
      Q6IE84, Q6ZPI0, Q8C7S6, Q8CFM2, Q8R362
      Conserved Domains (2) summary
      COG5141
      Location:100528
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:259369
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
    3. XM_006500784.4XP_006500847.1  protein Jade-1 isoform X2

      Conserved Domains (2) summary
      COG5141
      Location:115543
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:274384
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins