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    Zrsr2 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 [ Mus musculus (house mouse) ]

    Gene ID: 22184, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zrsr2provided by MGI
    Official Full Name
    zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2provided by MGI
    Primary source
    MGI:MGI:103287
    See related
    Ensembl:ENSMUSG00000031370 AllianceGenome:MGI:103287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    URP; 35kDa; U2af1-rs2; 5031411E02Rik; A230052C13Rik
    Summary
    Predicted to enable identical protein binding activity and pre-mRNA 3'-splice site binding activity. Predicted to be involved in spliceosomal complex assembly. Located in nucleolus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; intestine; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.6), limb E14.5 (RPKM 2.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zrsr2 in Genome Data Viewer
    Location:
    X F5; X 75.99 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (162719268..162741662, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (163932594..163958666, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein C8orf59 homolog Neighboring gene STARR-seq mESC enhancer starr_48234 Neighboring gene STARR-positive B cell enhancer ABC_E11688 Neighboring gene predicted gene, 52456 Neighboring gene adaptor-related protein complex 1, sigma 2 subunit Neighboring gene STARR-seq mESC enhancer starr_48235 Neighboring gene predicted gene, 38561 Neighboring gene carbonic anhydrase 5b, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E1986 Neighboring gene siah E3 ubiquitin protein ligase 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development. Gómez-Redondo I, et al. iScience, 2022 Feb 18. PMID 35198906, Free PMC Article
    2. Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice. Garcia-Ruiz C, et al. Leukemia, 2022 Oct. PMID 36030305, Free PMC Article
    3. Cloning and mapping of the U2af1-rs2 gene with a high transmission distortion in interspecific backcross progeny. Yamaoka T, et al. Genomics, 1995 May 20. PMID 7558001
    4. ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells. Madan V, et al. Haematologica, 2022 Mar 1. PMID 33691379, Free PMC Article
    5. Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. Kitagawa K, et al. Genomics, 1995 Nov 20. PMID 8586425

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.
      Title: Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.
    2. ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.
      Title: ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.
    3. Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.
      Title: Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA 3'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA 3'-splice site binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pre-mRNA 3'-splice site binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spliceosomal complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U12-type spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2AF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2AF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
    Names
    U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 35 kDa, related sequence 2
    U2(RNU2) small nuclear RNA auxiliary factor 1-like 2
    U2AF35-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009453.4 → NP_033479.2  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform 1

      See identical proteins and their annotated locations for NP_033479.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BX469932
      Consensus CDS
      CCDS41204.1
      UniProtKB/Swiss-Prot
      Q62377
      UniProtKB/TrEMBL
      B1B0E8
      Related
      ENSMUSP00000107908.3, ENSMUST00000112289.9
      Conserved Domains (3) summary
      smart00356
      Location:310 → 335
      ZnF_C3H1; zinc finger
      cd12540
      Location:203 → 307
      RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins
      pfam00642
      Location:171 → 195
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    2. NM_178794.4 → NP_848909.2  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons in the 3' coding region, and has a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      BC065693, BX469932
      Consensus CDS
      CCDS41205.1
      UniProtKB/TrEMBL
      B1B0E9
      Related
      ENSMUSP00000088350.4, ENSMUST00000090840.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      162719268..162741662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161905.1 → XP_036017798.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X1

      Conserved Domains (3) summary
      smart00356
      Location:168 → 193
      ZnF_C3H1; zinc finger
      pfam00642
      Location:29 → 53
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cd12540
      Location:61 → 165
      RRM_U2AFBPL; RNA recognition motif (RRM) found in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins

    2. XM_036161906.1 → XP_036017799.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X1

      Conserved Domains (3) summary
      smart00356
      Location:168 → 193
      ZnF_C3H1; zinc finger
      pfam00642
      Location:29 → 53
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cd12540
      Location:61 → 165
      RRM_U2AFBPL; RNA recognition motif (RRM) found in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins

    3. XM_011247815.4 → XP_011246117.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011246117.1

      Conserved Domains (2) summary
      smart00356
      Location:102 → 127
      ZnF_C3H1; zinc finger
      cd12540
      Location:1 → 99
      RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins

    4. XM_011247814.4 → XP_011246116.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011246116.1

      Conserved Domains (2) summary
      smart00356
      Location:102 → 127
      ZnF_C3H1; zinc finger
      cd12540
      Location:1 → 99
      RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins

    5. XM_006528797.5 → XP_006528860.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006528860.1

      Conserved Domains (2) summary
      smart00356
      Location:102 → 127
      ZnF_C3H1; zinc finger
      cd12540
      Location:1 → 99
      RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62377.1 GenPept UniProtKB/Swiss-Prot:Q62377

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