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    Adipoq adiponectin, C1Q and collagen domain containing [ Mus musculus (house mouse) ]

    Gene ID: 11450, updated on 14-Jan-2025

    Summary

    Official Symbol
    Adipoqprovided by MGI
    Official Full Name
    adiponectin, C1Q and collagen domain containingprovided by MGI
    Primary source
    MGI:MGI:106675
    See related
    Ensembl:ENSMUSG00000022878 AllianceGenome:MGI:106675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ad; APN; Acdc; Adid; apM1; 30kDa; GBP28; adipo; Acrp30
    Summary
    Enables hormone activity; identical protein binding activity; and protein serine/threonine kinase activator activity. Involved in several processes, including detection of oxidative stress; regulation of cold-induced thermogenesis; and regulation of protein serine/threonine kinase activity. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including brown fat cell differentiation; positive regulation of D-glucose import; and regulation of small molecule metabolic process. Located in endoplasmic reticulum and extracellular space. Is expressed in several structures, including adipose tissue; early conceptus; gut; reproductive system; and serum. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); liver disease (multiple); primary open angle glaucoma; prostate adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 1033.0), mammary gland adult (RPKM 560.0) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Adipoq in Genome Data Viewer
    Location:
    16 B1; 16 13.96 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22965286..22976718)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23146536..23157968)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene predicted gene, 24616 Neighboring gene replication factor C (activator 1) 4 Neighboring gene STARR-positive B cell enhancer ABC_E8623 Neighboring gene adiponectin enhancer region Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:23165651-23165889 Neighboring gene RIKEN cDNA C730014E05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:23181839-23182022 Neighboring gene predicted pseudogene 6630 Neighboring gene predicted gene 15746

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent PubMed 
    enables hormone activity PubMed 
    enables hormone activity  
    enables hormone activity PubMed 
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein serine/threonine kinase activator activity PubMed 
    enables sialic acid binding  
    enables sialic acid binding  
    enables signaling receptor binding PubMed 
    Items 1 - 25 of 113
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation PubMed 
    involved_in cellular response to cAMP  
    involved_in cellular response to cAMP  
    involved_in cellular response to epinephrine stimulus  
    involved_in cellular response to epinephrine stimulus  
    acts_upstream_of_or_within cellular response to insulin stimulus PubMed 
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to xenobiotic stimulus PubMed 
    involved_in circadian rhythm  
    involved_in detection of oxidative stress PubMed 
    acts_upstream_of_or_within fatty acid beta-oxidation PubMed 
    acts_upstream_of_or_within fatty acid oxidation PubMed 
    acts_upstream_of_or_within_positive_effect gene expression PubMed 
    acts_upstream_of_or_within glucose homeostasis PubMed 
    acts_upstream_of_or_within glucose homeostasis PubMed 
    acts_upstream_of_or_within glucose metabolic process PubMed 
    acts_upstream_of_or_within glucose metabolic process PubMed 
    involved_in low-density lipoprotein particle clearance  
    involved_in low-density lipoprotein particle clearance  
    involved_in negative regulation of DNA biosynthetic process  
    involved_in negative regulation of DNA biosynthetic process  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of MAP kinase activity PubMed 
    involved_in negative regulation of blood pressure  
    involved_in negative regulation of blood pressure  
    involved_in negative regulation of canonical NF-kappaB signal transduction  
    involved_in negative regulation of canonical NF-kappaB signal transduction  
    involved_in negative regulation of cell migration PubMed 
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in negative regulation of fat cell differentiation PubMed 
    involved_in negative regulation of fat cell differentiation  
    acts_upstream_of_or_within negative regulation of gluconeogenesis PubMed 
    involved_in negative regulation of granulocyte differentiation  
    involved_in negative regulation of granulocyte differentiation  
    involved_in negative regulation of heterotypic cell-cell adhesion  
    involved_in negative regulation of heterotypic cell-cell adhesion  
    involved_in negative regulation of hormone secretion  
    involved_in negative regulation of hormone secretion  
    involved_in negative regulation of inflammatory response PubMed 
    involved_in negative regulation of intracellular protein transport  
    involved_in negative regulation of intracellular protein transport  
    acts_upstream_of negative regulation of low-density lipoprotein receptor activity  
    involved_in negative regulation of macrophage derived foam cell differentiation  
    involved_in negative regulation of macrophage derived foam cell differentiation  
    involved_in negative regulation of macrophage differentiation  
    involved_in negative regulation of macrophage differentiation  
    involved_in negative regulation of metanephric mesenchymal cell migration PubMed 
    involved_in negative regulation of phagocytosis  
    involved_in negative regulation of phagocytosis  
    involved_in negative regulation of platelet-derived growth factor receptor signaling pathway PubMed 
    involved_in negative regulation of platelet-derived growth factor receptor signaling pathway  
    involved_in negative regulation of platelet-derived growth factor receptor-alpha signaling pathway PubMed 
    involved_in negative regulation of protein autophosphorylation  
    involved_in negative regulation of protein autophosphorylation  
    involved_in negative regulation of receptor binding  
    involved_in negative regulation of receptor binding  
    involved_in negative regulation of synaptic transmission  
    involved_in negative regulation of synaptic transmission  
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in negative regulation of vascular associated smooth muscle cell migration  
    involved_in negative regulation of vascular associated smooth muscle cell migration  
    involved_in negative regulation of vascular associated smooth muscle cell proliferation  
    involved_in negative regulation of vascular associated smooth muscle cell proliferation  
    acts_upstream_of_or_within positive regulation of D-glucose import PubMed 
    involved_in positive regulation of cAMP-dependent protein kinase activity PubMed 
    involved_in positive regulation of cAMP-dependent protein kinase activity  
    involved_in positive regulation of cAMP/PKA signal transduction  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of cholesterol efflux  
    involved_in positive regulation of cholesterol efflux  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    acts_upstream_of_or_within positive regulation of fatty acid metabolic process PubMed 
    involved_in positive regulation of glycogen (starch) synthase activity  
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of lipid transporter activity  
    involved_in positive regulation of lipid transporter activity  
    involved_in positive regulation of metanephric podocyte development PubMed 
    involved_in positive regulation of monocyte chemotactic protein-1 production  
    involved_in positive regulation of monocyte chemotactic protein-1 production  
    involved_in positive regulation of myeloid cell apoptotic process  
    involved_in positive regulation of myeloid cell apoptotic process  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of protein kinase A signaling  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of renal albumin absorption PubMed 
    involved_in positive regulation of renal albumin absorption  
    acts_upstream_of_or_within positive regulation of signal transduction PubMed 
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    involved_in regulation of glucose metabolic process  
    involved_in regulation of glucose metabolic process  
    involved_in response to activity  
    acts_upstream_of_or_within response to bacterium PubMed 
    involved_in response to ethanol  
    involved_in response to glucocorticoid  
    acts_upstream_of_or_within response to glucose PubMed 
    acts_upstream_of_or_within response to glucose PubMed 
    involved_in response to hypoxia  
    involved_in response to linoleic acid  
    involved_in response to nutrient  
    involved_in response to sucrose  
    involved_in response to tumor necrosis factor  
    involved_in response to tumor necrosis factor  
    involved_in signal transduction  
    Items 1 - 25 of 113
    Component Evidence Code Pubs
    located_in cell periphery  
    located_in cell surface  
    located_in cell surface  
    part_of collagen trimer  
    located_in endoplasmic reticulum PubMed 
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in perinuclear region of cytoplasm  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    adiponectin
    Names
    30 kDa adipocyte complement-related protein
    adipocyte complement related protein
    adipocyte complement-related 30 kDa protein
    adipocyte, C1Q and collagen domain containing
    adipocyte, C1q and collagen domain-containing protein
    adipocyte-specific protein AdipoQ
    adiponectin d

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009605.5NP_033735.3  adiponectin precursor

      See identical proteins and their annotated locations for NP_033735.3

      Status: VALIDATED

      Source sequence(s)
      AK134112
      Consensus CDS
      CCDS28075.1
      UniProtKB/Swiss-Prot
      Q60994, Q62400, Q6GTX4, Q9DC68
      UniProtKB/TrEMBL
      Q8BRW2
      Related
      ENSMUSP00000023593.6, ENSMUST00000023593.6
      Conserved Domains (2) summary
      smart00110
      Location:112245
      C1Q; Complement component C1q domain
      pfam01391
      Location:45107
      Collagen; Collagen triple helix repeat (20 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      22965286..22976718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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