RPT1 proteasome regulatory particle base subunit RPT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPT1
Official Full Name: proteasome regulatory particle base subunit RPT1
Primary source: SGD:S000001628
Locus tag: YKL145W
See related: AllianceGenome:SGD:S000001628; FungiDB:YKL145W; VEuPathDB:YKL145W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CIM5; YTA3
Summary: Enables ubiquitin protein ligase binding activity. Involved in positive regulation of macromolecule metabolic process; proteasome regulatory particle assembly; and ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle, base subcomplex. Used to study cancer. Orthologous to human PSMC2 (proteasome 26S subunit, ATPase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPT1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (174213..175616)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studied the yeast Rpt1 subunit and showed that following the removal of the initiation Met residue, the N-terminal Pro residue is either unmodified,mono-methylated, or di-methylated, and that this N-methylation has not been conserved throughout evolution.
Title: N-Terminal methylation of proteasome subunit Rpt1 in yeast.
Data show that proteasome subunits Rpt1, Rpt4, Rpn8, Rpn12, Pre6, and Pre10 are recruited to GAL10 rapidly upon galactose induction.
Title: Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin.
We determined the crystal structures of Hsm3 and its complex with the C-terminal domain of the Rpt1 subunit.
Title: Structural basis for specific recognition of Rpt1p, an ATPase subunit of 26 S proteasome, by proteasome-dedicated chaperone Hsm3p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macromolecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome regulatory particle assembly	IEA Inferred from Electronic Annotation more info
involved_in proteasome regulatory particle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, base subcomplex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, base subcomplex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome regulatory particle base subunit RPT1

NP_012777.1

ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

174213..175616

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179711.1 → NP_012777.1 TPA: proteasome regulatory particle base subunit RPT1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012777.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX51, P33299

UniProtKB/TrEMBL

A6ZZH6, B3LQV5, C7GSN8, C8ZC29, G2WHP3, N1P152

Conserved Domains (1) summary

COG1222
Location:28 → 464

RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]