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    SAP185 Sap185p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853347, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAP185
    Official Full Name
    Sap185p
    Primary source
    SGD:S000003634
    Locus tag
    YJL098W
    See related
    AllianceGenome:SGD:S000003634; FungiDB:YJL098W; VEuPathDB:YJL098W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein phosphatase regulator activity. Involved in G1/S transition of mitotic cell cycle and tRNA wobble uridine modification. Acts upstream of or within positive regulation of potassium ion export across plasma membrane. Is active in mitochondrion. Orthologous to several human genes including PPP6R1 (protein phosphatase 6 regulatory subunit 1) and PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAP185 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (242082..245258)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene 1-phosphatidylinositol 4-kinase LSB6 Neighboring gene Chs6p Neighboring gene enoyl-CoA hydratase PHS1 Neighboring gene mitochondrial 54S ribosomal protein YmL49

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sit4p protein phosphatase is required for sensitivity of Saccharomyces cerevisiae to Kluyveromyces lactis zymocin. Jablonowski D, et al. Genetics, 2001 Dec. PMID 11779790, Free PMC Article
    2. TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. Rohde JR, et al. Mol Cell Biol, 2004 Oct. PMID 15367655, Free PMC Article
    3. Genomic and Targeted Approaches Unveil the Cell Membrane as a Major Target of the Antifungal Cytotoxin Amantelide A. Elsadek LA, et al. Chembiochem, 2021 May 14. PMID 33527693, Free PMC Article
    4. Genetic variants of TORC1 signaling pathway affect nitrogen consumption in Saccharomyces cerevisiae during alcoholic fermentation. Molinet J, et al. PLoS One, 2019. PMID 31348805, Free PMC Article
    5. The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase. Luke MM, et al. Mol Cell Biol, 1996 Jun. PMID 8649382, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of potassium ion export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of potassium ion export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sap185p
    NP_012437.1
    • Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      242082..245258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181531.1 → NP_012437.1  TPA: Sap185p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012437.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW86, P40856
      UniProtKB/TrEMBL
      B3LQ15, N1P0T1
      Conserved Domains (1) summary
      pfam04499
      Location:259 → 772
      SAPS; SIT4 phosphatase-associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40856.1

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