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    GIC1 Gic1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856458, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GIC1
    Official Full Name
    Gic1p
    Primary source
    SGD:S000001103
    Locus tag
    YHR061C
    See related
    AllianceGenome:SGD:S000001103; FungiDB:YHR061C; VEuPathDB:YHR061C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables small GTPase binding activity. Involved in several processes, including Cdc42 protein signal transduction; regulation of exit from mitosis; and septin ring organization. Located in several cellular components, including cellular bud tip; incipient cellular bud site; and mating projection tip. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GIC1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (221534..222478, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein FYV4 Neighboring gene Vma22p Neighboring gene RNA-binding RNA processing protein RPP1 Neighboring gene 2-dehydropantoate 2-reductase PAN5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation. Sadian Y, et al. Elife, 2013 Nov 28. PMID 24286829, Free PMC Article
    2. The Cdc42 effectors Gic1 and Gic2 regulate polarized post-Golgi secretion. Liu Y, et al. Cell Biosci, 2019. PMID 30988896, Free PMC Article
    3. A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature. Daniels CN, et al. PLoS One, 2018. PMID 30566437, Free PMC Article
    4. Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast. Brown JL, et al. Genes Dev, 1997 Nov 15. PMID 9367980, Free PMC Article
    5. Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis. Okada S, et al. Dev Cell, 2013 Jul 29. PMID 23906065, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In yeast cells, Cdc42 polarization involves a positive feedback loop in which effectors called p21-activated kinases (PAKs) act to recruit a Cdc42-directed guanine nucleotide exchange factor (GEF), generating more GTP-Cdc42 in areas that already have GTP-Cdc42. The GTPase-interacting components (GICs) Gic1 and Gic2 are also Cdc42 effectors, and have been implicated in regulation of the actin and septin cytoskeleton.
      Title: A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature.
    2. we performed domain analysis to identify domain(s) of Gic1 that are important for its boundary activity, and identified two minimum domains, which are located outside its Cdc42-binding domain.
      Title: Gic1 is a novel heterochromatin boundary protein in vivo.
    3. we have used electron microscopy and cryo electron tomography to elucidate the structural basis of the Gic1-septin and Gic1-Cdc42-septin interaction
      Title: The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation.
    4. High-copy GIC1 suppresses the growth defect of a PKC1 mutant (stt1), suggesting the existence of a Pkc1-Zds1-Gic1 pathway.
      Title: Pkc1 acts through Zds1 and Gic1 to suppress growth and cell polarity defects of a yeast eIF5A mutant.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septin ring organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in septin ring organization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud tip HDA PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Gic1p
    NP_011928.1
    • Rho-family GTPase interacting protein and Cdc42p effector; required with Gic2p for polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit; relocalizes from bud neck to nucleus upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      221534..222478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179191.1 → NP_011928.1  TPA: Gic1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011928.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL10, P38785
      UniProtKB/TrEMBL
      A6ZSW7, C7GTX2, G2WFD3, N1P231
      Conserved Domains (1) summary
      cd00132
      Location:124 → 162
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38785.1

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