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    ZPR1 zinc finger-containing protein ZPR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZPR1
    Official Full Name
    zinc finger-containing protein ZPR1
    Primary source
    SGD:S000003443
    Locus tag
    YGR211W
    See related
    AllianceGenome:SGD:S000003443; FungiDB:YGR211W; VEuPathDB:YGR211W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein folding chaperone and translation elongation factor binding activity. Involved in 'de novo' protein folding and G2/M transition of mitotic cell cycle. Located in cytoplasm and nucleus. Orthologous to human ZPR1 (ZPR1 zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZPR1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (915241..916701)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene thioredoxin TRX2 Neighboring gene uncharacterized protein Neighboring gene N-acetyltransferase Neighboring gene Rta1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes. Mishra AK, et al. Proc Natl Acad Sci U S A, 2007 Aug 28. PMID 17704259, Free PMC Article
    2. Zinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis. Sabbarini IM, et al. Mol Cell, 2023 Jan 19. PMID 36630955, Free PMC Article
    3. The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. Galcheva-Gargova Z, et al. Mol Biol Cell, 1998 Oct. PMID 9763455, Free PMC Article
    4. Cyclophilin A peptidyl-prolyl isomerase activity promotes ZPR1 nuclear export. Ansari H, et al. Mol Cell Biol, 2002 Oct. PMID 12242280, Free PMC Article
    5. A Zpr1 co-chaperone mediates folding of eukaryotic translation elongation factor 1A via a GTPase cycle. McQuown AJ, et al. Mol Cell, 2023 Sep 7. PMID 37597513, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables translation elongation factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger-containing protein ZPR1
    NP_011727.3
    • Chaperone with two zinc fingers essential for eEF1A biogenesis; nuclear in growing cells, cytoplasmic in starved cells; shuttled via process mediated by Cpr1p; binds translation elongation factor eEF-1 (Tef1p); relative distribution to nucleus increases upon DNA replication stress; human ZPR1 gene can complement yeast by allowing growth during down-regulation of yeast zpr1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      915241..916701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181340.3 → NP_011727.3  TPA: zinc finger-containing protein ZPR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011727.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUZ4, P53303, Q02807, Q02808
      UniProtKB/TrEMBL
      A6ZUM2, B3LI25, B5VJF1, C7GRP4, C8Z9A4, G2WEU0, N1P2J7
      Conserved Domains (2) summary
      TIGR00310
      Location:293 → 486
      ZPR1_znf; ZPR1 zinc finger domain
      pfam03367
      Location:52 → 210
      zf-ZPR1; ZPR1 zinc-finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53303.1

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