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    ARI1 carbonyl reductase (NADPH-dependent) ARI1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ARI1
    Official Full Name
    carbonyl reductase (NADPH-dependent) ARI1
    Primary source
    SGD:S000003125
    Locus tag
    YGL157W
    See related
    AllianceGenome:SGD:S000003125; FungiDB:YGL157W; VEuPathDB:YGL157W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables carbonyl reductase (NADPH) activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ARI1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (209006..210049)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene putative serine/threonine protein kinase RCK1 Neighboring gene alpha-mannosidase Neighboring gene protein geranylgeranyltransferase type I subunit CDC43

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stereochemistry of furfural reduction by a Saccharomyces cerevisiae aldehyde reductase that contributes to in situ furfural detoxification. Bowman MJ, et al. Appl Environ Microbiol, 2010 Aug. PMID 20525870, Free PMC Article
    2. Kinetic mechanism of an aldehyde reductase of Saccharomyces cerevisiae that relieves toxicity of furfural and 5-hydroxymethylfurfural. Jordan DB, et al. Biochim Biophys Acta, 2011 Dec. PMID 21890004
    3. Short-chain dehydrogenases/reductases (SDRs). Kallberg Y, et al. Eur J Biochem, 2002 Sep. PMID 12230552
    4. Studying NAD(P)H cofactor-binding to alcohol dehydrogenases through global analysis of circular dichroism spectra. Marolt M , et al. Phys Chem Chem Phys, 2019 Jan 23. PMID 30328850
    5. Efficient anaerobic whole cell stereoselective bioreduction with recombinant Saccharomyces cerevisiae. Katz M, et al. Biotechnol Bioeng, 2003 Dec 5. PMID 14574691

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinetic mechanism of an aldehyde reductase of Saccharomyces cerevisiae that relieves toxicity of furfural and 5-hydroxymethylfurfural.
      Title: Kinetic mechanism of an aldehyde reductase of Saccharomyces cerevisiae that relieves toxicity of furfural and 5-hydroxymethylfurfural.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carbonyl reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carbonyl reductase (NADPH-dependent) ARI1
    NP_011358.3
    • NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      209006..210049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181022.3 → NP_011358.3  TPA: carbonyl reductase (NADPH-dependent) ARI1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011358.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTZ4, P53111
      UniProtKB/TrEMBL
      B3LHL0, C7GPP9, N1P4P9
      Conserved Domains (1) summary
      cd05227
      Location:6 → 323
      AR_SDR_e; aldehyde reductase, extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53111.1

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