IME4 mRNA (N6-adenosine)-methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: IME4
Official Full Name: mRNA (N6-adenosine)-methyltransferase
Primary source: SGD:S000003160
Locus tag: YGL192W
See related: AllianceGenome:SGD:S000003160; FungiDB:YGL192W; VEuPathDB:YGL192W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SPO8
Summary: Enables mRNA m(6)A methyltransferase activity. Involved in meiotic DNA replication initiation and negative regulation of pseudohyphal growth. Part of RNA N6-methyladenosine methyltransferase complex. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA m(6)A methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA m(6)A methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mRNA m(6)A methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of pseudohyphal growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sporulation resulting in formation of a cellular spore	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA N6-methyladenosine methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA N6-methyladenosine methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_011323.3

mRNA N6-adenosine methyltransferase; essential for meiosis in S288C but dispensable for meiosis in SK1, mediates N6-adenosine methylation of bulk mRNA during the induction of sporulation which includes the meiotic regulators IME1, IME2 and IME4 itself; repressed in haploids via production of antisense IME4 transcripts; transcribed in diploid cells where antisense transcription is repressed; orthologous to human METTL3 (MT-A70)

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain