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    VPS72 Vps72p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852096, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS72
    Official Full Name
    Vps72p
    Primary source
    SGD:S000002893
    Locus tag
    YDR485C
    See related
    AllianceGenome:SGD:S000002893; FungiDB:YDR485C; VEuPathDB:YDR485C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SWC2
    Summary
    Enables histone binding activity. Involved in chromatin remodeling. Located in cytoplasm and nucleus. Part of Swr1 complex. Orthologous to human VPS72 (vacuolar protein sorting 72 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS72 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1424820..1427207, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene alpha-1,2-mannosyltransferase KRE2 Neighboring gene Vps52p Neighboring gene Vps60p Neighboring gene 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SWR-C and INO80 chromatin remodelers recognize nucleosome-free regions near +1 nucleosomes. Yen K, et al. Cell, 2013 Sep 12. PMID 24034248, Free PMC Article
    2. Recognition of the inherently unstable H2A nucleosome by Swc2 is a major determinant for unidirectional H2A.Z exchange. Dai L, et al. Cell Rep, 2021 May 25. PMID 34038732
    3. Mutations in non-acid patch residues disrupt H2A.Z's association with chromatin through multiple mechanisms. Wood TJ, et al. PLoS One, 2013. PMID 24098487, Free PMC Article
    4. The SWR1 histone replacement complex causes genetic instability and genome-wide transcription misregulation in the absence of H2A.Z. Morillo-Huesca M, et al. PLoS One, 2010 Aug 12. PMID 20711347, Free PMC Article
    5. Roles for H2A.Z and its acetylation in GAL1 transcription and gene induction, but not GAL1-transcriptional memory. Halley JE, et al. PLoS Biol, 2010 Jun 22. PMID 20582323, Free PMC Article

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Swc2 binds directly to and is essential for transfer of H2AZ.
      Title: Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vps72p
    NP_010773.4
    • Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1424820..1427207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180793.3 → NP_010773.4  TPA: Vps72p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010773.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTA8, Q03388
      UniProtKB/TrEMBL
      B3LFI1, C7GKS3
      Conserved Domains (2) summary
      smart00993
      Location:708 → 737
      YL1_C; YL1 nuclear protein C-terminal domain
      pfam05764
      Location:21 → 292
      YL1; YL1 nuclear protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03388.2

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