HPT1 hypoxanthine phosphoribosyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HPT1
Official Full Name: hypoxanthine phosphoribosyltransferase
Primary source: SGD:S000002807
Locus tag: YDR399W
See related: AllianceGenome:SGD:S000002807; FungiDB:YDR399W; VEuPathDB:YDR399W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BRA6
Summary: Enables hypoxanthine phosphoribosyltransferase activity. Involved in GMP salvage and IMP salvage. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HPT1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1270068..1270733)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

characterization o several mutations making yeast hypoxanthine-guanine phosphoribosyltransferase insensitive to feedback inhibition by GMP.
Title: Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables guanine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hypoxanthine phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hypoxanthine phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables hypoxanthine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hypoxanthine phosphoribosyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables hypoxanthine phosphoribosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GMP salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in GMP salvage	IDA Inferred from Direct Assay more info	PubMed
involved_in GMP salvage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in GMP salvage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in IMP salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP salvage	IDA Inferred from Direct Assay more info	PubMed
involved_in IMP salvage	IEA Inferred from Electronic Annotation more info
involved_in XMP salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in hypoxanthine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hypoxanthine phosphoribosyltransferase

NP_010687.3

EC 2.4.2.8

Dimeric hypoxanthine-guanine phosphoribosyltransferase; catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1270068..1270733

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180707.3 → NP_010687.3 TPA: hypoxanthine phosphoribosyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010687.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT32, Q04178

UniProtKB/TrEMBL

A6ZYZ9, B3LFQ2, B5VGT1, C7GSC4, C8Z5W3, G2WBD8, N1P5H4

Conserved Domains (1) summary

COG2236
Location:3 → 206

Hpt1; Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]