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    SAC7 GTPase-activating protein SAC7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851997, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAC7
    Official Full Name
    GTPase-activating protein SAC7
    Primary source
    SGD:S000002797
    Locus tag
    YDR389W
    See related
    AllianceGenome:SGD:S000002797; FungiDB:YDR389W; VEuPathDB:YDR389W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Involved in negative regulation of Rho protein signal transduction; regulation of actin cytoskeleton organization; and regulation of fungal-type cell wall organization. Located in cell cortex. Orthologous to human GMIP (GEM interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAC7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1252537..1254501)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cin10p Neighboring gene amphiphysin Neighboring gene E1 ubiquitin-activating protein UBA2 Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Null alleles of SAC7 suppress temperature-sensitive actin mutations in Saccharomyces cerevisiae. Dunn TM, et al. Mol Cell Biol, 1990 May. PMID 2183030, Free PMC Article
    2. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Schmidt A, et al. Cell, 1997 Feb 21. PMID 9038344
    3. Lrg1p functions as a putative GTPase-activating protein in the Pkc1p-mediated cell integrity pathway in Saccharomyces cerevisiae. Lorberg A, et al. Mol Genet Genomics, 2001 Nov. PMID 11713681
    4. The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae. Schmidt A, et al. Mol Microbiol, 2002 Sep. PMID 12207708
    5. Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway. deHart AK, et al. Mol Biol Cell, 2003 Nov. PMID 14593073, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of fungal-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating protein SAC7
    NP_010677.1
    • GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity (CWI) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1252537..1254501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180697.1 → NP_010677.1  TPA: GTPase-activating protein SAC7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010677.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT23, P17121, Q04163
      UniProtKB/TrEMBL
      B3LFR1, C7GSD3, C8Z5V3, N1P5G3
      Conserved Domains (1) summary
      cd04396
      Location:122 → 393
      RhoGAP_fSAC7_BAG7; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17121.2

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