HNT1 adenosine 5'-monophosphoramidase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: HNT1
Official Full Name: adenosine 5'-monophosphoramidase
Primary source: SGD:S000002283
Locus tag: YDL125C
See related: AllianceGenome:SGD:S000002283; FungiDB:YDL125C; VEuPathDB:YDL125C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables adenosine 5'-monophosphoramidase activity. Involved in nucleotide metabolic process. Located in cytoplasm and nucleus. Used to study Gamstorp-Wohlfart syndrome. Human ortholog(s) of this gene implicated in Gamstorp-Wohlfart syndrome. Orthologous to several human genes including HINT1 (histidine triad nucleotide binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Changes in transcription start sites of Zap1-regulated genes during zinc deficiency: Implications for HNT1 gene regulation.
Title: Changes in transcription start sites of Zap1-regulated genes during zinc deficiency: Implications for HNT1 gene regulation.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables adenosine 5'-monophosphoramidase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenosine 5'-monophosphoramidase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in nucleotide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed

NP_010158.1

Adenosine 5'-monophosphoramidase; interacts physically and genetically with CDK and TFIIK subunit Kin28p, and genetically with CAK1; member of histidine triad (HIT) superfamily of nucleotide-binding proteins; protein abundance increases in response to DNA replication stress; human homolog HINT1 can complement yeast hnt1 mutant

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The following sections contain reference sequences that belong to a specific genome build. Explain