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    EMC1 Emc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850312, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EMC1
    Official Full Name
    Emc1p
    Primary source
    SGD:S000000550
    Locus tag
    YCL045C
    See related
    AllianceGenome:SGD:S000000550; FungiDB:YCL045C; VEuPathDB:YCL045C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein folding in endoplasmic reticulum. Located in endoplasmic reticulum. Part of EMC complex. Human ortholog(s) of this gene implicated in cerebellar atrophy, visual impairment, and psychomotor retardation. Orthologous to human EMC1 (ER membrane protein complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EMC1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (44623..46905, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Sps22p Neighboring gene nicotinamide-nucleotide adenylyltransferase Neighboring gene Mgr1p Neighboring gene protein disulfide isomerase PDI1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Miller-Vedam LE, et al. Elife, 2020 Nov 25. PMID 33236988, Free PMC Article
    2. Identification of Gal80p-interacting proteins by Saccharomyces cerevisiae whole genome phage display. Hertveldt K, et al. Gene, 2003 Mar 27. PMID 12706896
    3. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
    4. Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Richard M, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431131, Free PMC Article
    5. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding in endoplasmic reticulum HGI PubMed 
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of EMC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Emc1p
    NP_009884.1
    • Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      44623..46905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178690.1 → NP_009884.1  TPA: Emc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009884.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQX1, P25574
      UniProtKB/TrEMBL
      A6ZTE7, B3LU39, B5VER6, N1P7Y8
      Conserved Domains (2) summary
      COG0188
      Location:279 → 467
      GyrA; DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]
      pfam07774
      Location:538 → 757
      DUF1620; Protein of unknown function (DUF1620)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25574.1

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