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    TLC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 9164870, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TLC1
    Primary source
    SGD:S000006657
    Locus tag
    YNCB0010W
    See related
    AllianceGenome:SGD:S000006657
    Gene type
    ncRNA
    RNA name
    telomerase_RNA
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to telomerase activity. Involved in telomere maintenance via recombination and telomere maintenance via telomerase. Located in cytoplasm and nucleus. Part of telomerase catalytic core complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TLC1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (307587..308887)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene pyridoxamine-phosphate oxidase PDX3 Neighboring gene ncRNA Neighboring gene mannosylinositol phosphorylceramide synthase regulatory subunit Neighboring gene Cu-binding protein SCO1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Singer MS, et al. Science, 1994 Oct 21. PMID 7545955
    2. Live-cell imaging of budding yeast telomerase RNA and TERRA. Laprade H, et al. Methods, 2017 Feb 1. PMID 27474163
    3. Telomere configuration influences the choice of telomere maintenance pathways. Wen WY, et al. Biochem Biophys Res Commun, 2006 May 5. PMID 16546132
    4. A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein. Lin J, et al. Proc Natl Acad Sci U S A, 2004 Oct 12. PMID 15371596, Free PMC Article
    5. Structural elements required for association of the Saccharomyces cerevisiae telomerase RNA with the Est2 reverse transcriptase. Chappell AS, et al. Mol Cell Biol, 2004 Sep. PMID 15314178, Free PMC Article

    See all (166) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast Telomerase RNA Flexibly Scaffolds Protein Subunits: Results and Repercussions.
      Title: Yeast Telomerase RNA Flexibly Scaffolds Protein Subunits: Results and Repercussions.
    2. A lengthy conserved region of the Est1-binding TLC1 arm contributes more than simply Est1-binding function; it may be required for establishing telomere extendibility or promoting telomerase RNP holoenzyme activity.
      Title: A second essential function of the Est1-binding arm of yeast telomerase RNA.
    3. TLC1 export into the cytoplasm requires not only the Ran GTPase-dependent karyopherin Crm1/Xpo1 but also the mRNA export machinery.
      Title: Telomerase RNA TLC1 shuttling to the cytoplasm requires mRNA export factors and is important for telomere maintenance.
    4. TLC1 RNA is transcribed in a cell cycle-dependent fashion late in G1 and may be part of the S phase-regulated group of genes involved in DNA replication.
      Title: Cell cycle-dependent transcription factors control the expression of yeast telomerase RNA.
    5. Ku associates with a specific stem-loop of TLC1, the RNA subunit of budding yeast telomerase, and is necessary for proper nuclear localization of this ribonucleoprotein enzyme.
      Title: RNA recognition by the DNA end-binding Ku heterodimer.
    6. The results demonstrate that the function of the Tlc1 terminator region depends on the Nrd1/Nab3 transcription termination pathway.
      Title: Budding yeast telomerase RNA transcription termination is dictated by the Nrd1/Nab3 non-coding RNA termination pathway.
    7. Tracking of single telomerase particles revealed a diffusive behavior and transient association with telomeres in G1 and G2 phases of the cell cycle
      Title: Live cell imaging of telomerase RNA dynamics reveals cell cycle-dependent clustering of telomerase at elongating telomeres.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    • RNA template component of telomerase; flexible scaffold that tethers telomerase holoenzyme protein subunits to the complex; contains template sequence that Est2p uses to add irregular repeats of TG(1-3) residues onto a DNA end; promoter regulated by the cell cycle dependent transcriptional activators Swi4p/Swi6p and Mbp1p/Swi6p

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to telomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables template for synthesis of G-rich strand of telomere DNA activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in telomere maintenance via recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of telomerase catalytic core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      307587..308887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. NR_132153.1 RNA Sequence

      Status: REVIEWED

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