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    BSP1 Bsp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856301, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BSP1
    Official Full Name
    Bsp1p
    Primary source
    SGD:S000006375
    Locus tag
    YPR171W
    See related
    AllianceGenome:SGD:S000006375; FungiDB:YPR171W; VEuPathDB:YPR171W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables actin filament binding activity and protein-macromolecule adaptor activity. Involved in actin cortical patch localization; protein localization to actin cortical patch; and protein localization to mitotic actomyosin contractile ring. Located in several cellular components, including cellular bud neck; cellular bud tip; and cortical actin cytoskeleton. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BSP1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (883828..885558)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene uncharacterized protein Neighboring gene pyridoxal 5'-phosphate synthase Neighboring gene AAA family ATPase VPS4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bsp1, a fungal CPI motif protein, regulates actin filament capping in endocytosis and cytokinesis. Hummel DR, et al. Mol Biol Cell, 2024 Feb 1. PMID 38088874, Free PMC Article
    2. The Saccharomyces cerevisiae actin cytoskeletal component Bsp1p has an auxiliary role in actomyosin ring function and in the maintenance of bud-neck structure. Wright DJ, et al. Genetics, 2008 Apr. PMID 18430924, Free PMC Article
    3. Bsp1p/Ypr171p is an adapter that directly links some synaptojanin family members to the cortical actin cytoskeleton in yeast. Wicky S, et al. FEBS Lett, 2003 Feb 27. PMID 12606027
    4. Calcineurin regulates the yeast synaptojanin Inp53/Sjl3 during membrane stress. Guiney EL, et al. Mol Biol Cell, 2015 Feb 15. PMID 25518934, Free PMC Article
    5. Yeast Arf3p modulates plasma membrane PtdIns(4,5)P2 levels to facilitate endocytosis. Smaczynska-de Rooij II, et al. Traffic, 2008 Apr. PMID 18208507, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bsp1, a fungal CPI motif protein, regulates actin filament capping in endocytosis and cytokinesis.
      Title: Bsp1, a fungal CPI motif protein, regulates actin filament capping in endocytosis and cytokinesis.
    2. Mechanism of actin capping protein recruitment and turnover during clathrin-mediated endocytosis.
      Title: Mechanism of actin capping protein recruitment and turnover during clathrin-mediated endocytosis.
    3. Compromise of Iqg1p function, in the absence of Bsp1p function, leads to a profound change in the distribution of actin and the pattern of cell growth accompanied by a failure to complete cytokinesis and cell separation.
      Title: The Saccharomyces cerevisiae actin cytoskeletal component Bsp1p has an auxiliary role in actomyosin ring function and in the maintenance of bud-neck structure.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cortical patch localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to actin cortical patch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to mitotic actomyosin contractile ring IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bsp1p
    NP_015497.1
    • Actin filament binding protein; regulates actin filament capping by recruiting capping protein to endocytic sites and to the cytokinetic actin ring; interacts with the capping protein complex; adapter that links synaptojanins, Inp52p and Inp53p, to the cortical actin cytoskeleton; contains two WH2-like actin binding domains and a C-terminal capping protein interaction (CPI) motif

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      883828..885558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184268.1 → NP_015497.1  TPA: Bsp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015497.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4H2, Q06604
      UniProtKB/TrEMBL
      B3LKD1, C7GP54, C8ZJK0, N1NWK1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06604.1

    Gene LinkOut

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