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    LSP1 lipid-binding protein LSP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856103, updated on 17-Dec-2024

    Summary

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    Official Symbol
    LSP1
    Official Full Name
    lipid-binding protein LSP1
    Primary source
    SGD:S000005925
    Locus tag
    YPL004C
    See related
    AllianceGenome:SGD:S000005925; FungiDB:YPL004C; VEuPathDB:YPL004C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lipid binding activity. Involved in eisosome assembly; endocytosis; and response to heat. Acts upstream of or within membrane organization. Located in eisosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LSP1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (550632..551657, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene sphingolipid transporter Neighboring gene Aep3p Neighboring gene Ula1p Neighboring gene ESCRT-II subunit protein SNF8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Eisosomes are dynamic plasma membrane domains showing pil1-lsp1 heteroligomer binding equilibrium. Olivera-Couto A, et al. Biophys J, 2015 Apr 7. PMID 25863055, Free PMC Article
    2. Eisosome proteins assemble into a membrane scaffold. Karotki L, et al. J Cell Biol, 2011 Nov 28. PMID 22123866, Free PMC Article
    3. Lsp1 partially substitutes for Pil1 function in eisosome assembly under stress conditions. Vesela P, et al. J Cell Sci, 2023 Feb 1. PMID 36601791
    4. Eisosome-driven plasma membrane organization is mediated by BAR domains. Ziółkowska NE, et al. Nat Struct Mol Biol, 2011 Jun 19. PMID 21685922
    5. Phosphoproteomic analysis of protein kinase C signaling in Saccharomyces cerevisiae reveals Slt2 mitogen-activated protein kinase (MAPK)-dependent phosphorylation of eisosome core components. Mascaraque V, et al. Mol Cell Proteomics, 2013 Mar. PMID 23221999, Free PMC Article

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lsp1 partially substitutes for Pil1 function in eisosome assembly under stress conditions.
      Title: Lsp1 partially substitutes for Pil1 function in eisosome assembly under stress conditions.
    2. This probably is the first report showing that the transcription factor Bdf1p regulates endocytosis under salt stress via LSP1, a major component of eisosomes that regulate the sites of endocytosis.
      Title: The yeast BDF1 regulates endocytosis via LSP1 under salt stress.
    3. Data indicate that Pkc1-induced phosphorylation of the eisosome core components Pil1 and Lsp1 was not exerted directly by Pkc1, but involved signaling through the Slt2 MAPK module.
      Title: Phosphoproteomic analysis of protein kinase C signaling in Saccharomyces cerevisiae reveals Slt2 mitogen-activated protein kinase (MAPK)-dependent phosphorylation of eisosome core components.
    4. Seg1/Sle1 controls eisosome assembly and shape, which also involves Pil1 and Lsp1
      Title: Seg1 controls eisosome assembly and shape.
    5. Pil1 and Lsp1 self-assemble into higher-order structures and bind preferentially to phosphoinositide-containing membranes.
      Title: Eisosome proteins assemble into a membrane scaffold.
    6. large immobile protein assemblies at the plasma membrane in the yeast Saccharomyces cerevisiae that mark endocytic sites, termed eisosomes, are composed primarily of two cytoplasmic proteins, Pil1 and Lsp1
      Title: Eisosomes mark static sites of endocytosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in eisosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eisosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell periphery HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in eisosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eisosome filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lipid-binding protein LSP1
    NP_015321.1
    • Stress-responsive eisosome organizer and core component; eisosomes are large immobile patch structures at the cell cortex associated with endocytosis; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      550632..551657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183818.1 → NP_015321.1  TPA: lipid-binding protein LSP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015321.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W408, Q12230
      UniProtKB/TrEMBL
      A6ZWP2, B3LL58, B5VTF7, C7GV48, C8ZJ22, N1P1W7
      Conserved Domains (1) summary
      pfam13805
      Location:1 → 264
      Pil1; Eisosome component PIL1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12230.1

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