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    GID8 glucose-induced degradation complex subunit GID8 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855166, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GID8
    Official Full Name
    glucose-induced degradation complex subunit GID8
    Primary source
    SGD:S000004742
    Locus tag
    YMR135C
    See related
    AllianceGenome:SGD:S000004742; FungiDB:YMR135C; VEuPathDB:YMR135C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DCR1
    Summary
    Involved in negative regulation of gluconeogenesis; proteasome-mediated ubiquitin-dependent protein catabolic process; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleus. Part of GID complex. Orthologous to human GID8 (GID complex subunit 8 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GID8 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (538689..540056, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Rec114p Neighboring gene Erg29p Neighboring gene Gat2p Neighboring gene DNA cross-link repair protein PSO2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence. Childers DS, et al. PLoS Pathog, 2016 Apr. PMID 27073846, Free PMC Article
    2. Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae. Pathak R, et al. Eukaryot Cell, 2004 Dec. PMID 15590836, Free PMC Article
    3. Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae. Bogomolnaya LM, et al. Curr Genet, 2006 Jun. PMID 16552603
    4. Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. Menssen R, et al. J Biol Chem, 2012 Jul 20. PMID 22645139, Free PMC Article
    5. Regulation of the Gid ubiquitin ligase recognition subunit Gid4. Menssen R, et al. FEBS Lett, 2018 Oct. PMID 30136317

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hym1p requires Dcr2p(a phosphatase)and Gid8p (involved in protein degradation) to promote the transition from the G1 to S phase of the cell cycle
      Title: Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae.
    2. Gid8p (Dcr1p) and Dcr2p have roles in a common pathway to promote START completion in Saccharomyces cerevisiae
      Title: Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in traversing start control point of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose-induced degradation complex subunit GID8
    NP_013854.1
    • Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      538689..540056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182636.1 → NP_013854.1  TPA: glucose-induced degradation complex subunit GID8 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013854.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZV8, P40208
      UniProtKB/TrEMBL
      B3LM22, C8ZEZ0
      Conserved Domains (1) summary
      pfam10607
      Location:130 → 296
      CLTH; CTLH/CRA C-terminal to LisH motif domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40208.1

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