STO1 Sto1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: STO1
Official Full Name: Sto1p
Primary source: SGD:S000004732
Locus tag: YMR125W
See related: AllianceGenome:SGD:S000004732; FungiDB:YMR125W; VEuPathDB:YMR125W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CBC1; CBP80; GCR3; SUT1
Summary: Enables mRNA binding activity. Involved in mRNA splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and response to osmotic stress. Located in nucleus. Part of commitment complex and nuclear cap binding activity complex. Orthologous to human NCBP1 (nuclear cap binding protein subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See STO1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 2

Sequence:: Chromosome: XIII; NC_001145.3 (517539..520446)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our results indicate that binding of Cbc1 to the capped mRNAs is necessary for the accumulation of specific activators as well as PIC components at the promoters of genes whose expression requires high and rapid transcription.
Title: The mRNA cap-binding protein Cbc1 is required for high and timely expression of genes by promoting the accumulation of gene-specific activators at promoters.
Cbc1-mediated translation is necessary for the rapid translation of osmostress-protective proteins under osmotic stress
Title: Yeast mRNA cap-binding protein Cbc1/Sto1 is necessary for the rapid reprogramming of translation after hyperosmotic shock.
Cbp80 plays distinct roles in the recognition of the intron by U1 and U2 snRNP.
Title: RPL30 regulation of splicing reveals distinct roles for Cbp80 in U1 and U2 snRNP cotranscriptional recruitment.
searched for additional, novel targets of Prp28p. A screen identified Prp42p, Snu71p, and Cbp80p, all known components of commitment complexes, as well as Ynl187p, a protein of uncertain function.
Title: A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA cap binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	HDA more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 7-methylguanosine mRNA capping	IEA Inferred from Electronic Annotation more info
involved_in RNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IPI Inferred from Physical Interaction more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of commitment complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of nuclear cap binding complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear cap binding complex	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear cap binding complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sto1p

NP_013844.2

Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

517539..520446

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182626.1 → NP_013844.2 TPA: Sto1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013844.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZU8, P34160

UniProtKB/TrEMBL

A6ZMI5, B3LM16, C8ZEY0

Conserved Domains (3) summary

pfam09088
Location:346 → 541

MIF4G_like; MIF4G like

pfam02854
Location:36 → 264

MIF4G; MIF4G domain

pfam09090
Location:581 → 828

MIF4G_like_2; MIF4G like