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    Rnpc3 RNA-binding region (RNP1, RRM) containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691538, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnpc3provided by RGD
    Official Full Name
    RNA-binding region (RNP1, RRM) containing 3provided by RGD
    Primary source
    RGD:1582776
    See related
    EnsemblRapid:ENSRNOG00000017310 AllianceGenome:RGD:1582776
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable U12 snRNA binding activity and pre-mRNA intronic binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U12-type spliceosomal complex. Human ortholog(s) of this gene implicated in panhypopituitarism. Orthologous to human RNPC3 (RNA binding region (RNP1, RRM) containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 108.7), Spleen (RPKM 84.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnpc3 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (204121191..204145128, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (201432769..201457015, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (216481457..216510051, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene pancreatic alpha-amylase-like Neighboring gene amylase alpha 1 Neighboring gene uncharacterized LOC134485951 Neighboring gene ribosomal protein L5, pseudogene 7 Neighboring gene 39S ribosomal protein L30, mitochondrial-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Minor spliceosome components are predominantly localized in the nucleus. Pessa HK, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18559850, Free PMC Article
    2. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. Will CL, et al. RNA, 2004 Jun. PMID 15146077, Free PMC Article
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188204

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U12 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA intronic binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding region-containing protein 3
    Names
    RNA-binding motif protein 40
    RNA-binding protein 40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100810.1 → NP_001094280.1  RNA-binding region-containing protein 3

      See identical proteins and their annotated locations for NP_001094280.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166571
      UniProtKB/Swiss-Prot
      Q4G055
      UniProtKB/TrEMBL
      B2GV85
      Related
      ENSRNOP00000069232.1, ENSRNOT00000087714.3
      Conserved Domains (3) summary
      COG0724
      Location:311 → 510
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12238
      Location:28 → 100
      RRM1_RBM40_like; RNA recognition motif 1 in RNA-binding protein 40 (RBM40) and similar proteins
      cd12239
      Location:418 → 500
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      204121191..204145128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233211.5 → XP_006233273.1  RNA-binding region-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006233273.1

      UniProtKB/Swiss-Prot
      Q4G055
      UniProtKB/TrEMBL
      B2GV85
      Conserved Domains (3) summary
      COG0724
      Location:311 → 510
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12238
      Location:28 → 100
      RRM1_RBM40_like; RNA recognition motif 1 in RNA-binding protein 40 (RBM40) and similar proteins
      cd12239
      Location:418 → 500
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    2. XM_008761425.4 → XP_008759647.1  RNA-binding region-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QC18
      Conserved Domains (3) summary
      COG0724
      Location:311 → 497
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12238
      Location:28 → 100
      RRM1_RBM40_like; RNA recognition motif 1 in RNA-binding protein 40 (RBM40) and similar proteins
      cd12239
      Location:418 → 497
      RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

    RNA

    1. XR_005500373.2 RNA Sequence

    2. XR_005500372.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G055.2 GenPept UniProtKB/Swiss-Prot:Q4G055

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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