Zfp639 zinc finger protein 639 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp639provided by RGD
Official Full Name: zinc finger protein 639provided by RGD
Primary source: RGD:1585689
See related: EnsemblRapid:ENSRNOG00000043053 AllianceGenome:RGD:1585689
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Znf639
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation by host of viral transcription; positive regulation by host of viral transcription; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Orthologous to human ZNF639 (zinc finger protein 639). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 48.6), Muscle (RPKM 44.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (117220806..117231132)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (115292431..115305798)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (118906479..118917491)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH143780 (e-PCR)
- UniSTS:233026

AI406622 (e-PCR)
- UniSTS:250035

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation by host of viral transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation by host of viral transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation by host of viral transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in symbiont entry into host cell	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger protein 639

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080907.2 → NP_001074376.1 zinc finger protein 639

See identical proteins and their annotated locations for NP_001074376.1

Status: PROVISIONAL

Source sequence(s)

BC087704

UniProtKB/Swiss-Prot

Q5PPG4

UniProtKB/TrEMBL

A0A8I6A1H8, A6IHN9

Conserved Domains (2) summary

sd00017
Location:405 → 425

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam15909
Location:408 → 481

zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

117220806..117231132

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282536.1 → XP_063138606.1 zinc finger protein 639 isoform X1

UniProtKB/Swiss-Prot

Q5PPG4

UniProtKB/TrEMBL

A0A8I6A1H8, A6IHN9
XM_039103126.2 → XP_038959054.1 zinc finger protein 639 isoform X1

UniProtKB/Swiss-Prot

Q5PPG4

UniProtKB/TrEMBL

A0A8I6A1H8, A6IHN9

Conserved Domains (2) summary

sd00017
Location:405 → 425

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam15909
Location:408 → 481

zf-C2H2_8; C2H2-type zinc ribbon
XM_063282538.1 → XP_063138608.1 zinc finger protein 639 isoform X2

UniProtKB/TrEMBL

A0A8I6A1H8, A6IHP1
XM_006232254.4 → XP_006232316.1 zinc finger protein 639 isoform X1

See identical proteins and their annotated locations for XP_006232316.1

UniProtKB/Swiss-Prot

Q5PPG4

UniProtKB/TrEMBL

A0A8I6A1H8, A6IHN9

Related

ENSRNOP00000085015.2, ENSRNOT00000100539.2

Conserved Domains (2) summary

sd00017
Location:405 → 425

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam15909
Location:408 → 481

zf-C2H2_8; C2H2-type zinc ribbon
XM_039103127.2 → XP_038959055.1 zinc finger protein 639 isoform X1

UniProtKB/Swiss-Prot

Q5PPG4

UniProtKB/TrEMBL

A0A8I6A1H8, A6IHN9

Conserved Domains (2) summary

sd00017
Location:405 → 425

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam15909
Location:408 → 481

zf-C2H2_8; C2H2-type zinc ribbon