Grm3 glutamate metabotropic receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grm3provided by RGD
Official Full Name: glutamate metabotropic receptor 3provided by RGD
Primary source: RGD:2744
See related: EnsemblRapid:ENSRNOG00000005519 AllianceGenome:RGD:2744
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: mGluR3
Summary: Enables group II metabotropic glutamate receptor activity and scaffold protein binding activity. Involved in modulation of chemical synaptic transmission. Located in astrocyte projection and axon. Orthologous to human GRM3 (glutamate metabotropic receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 261.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (25319218..25600721)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (24364854..24643972)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (21316761..21567561)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERalphaDelta4, an ERalpha splice variant missing exon4, interacts with caveolin-3 and mGluR2/3.
Title: ERαΔ4, an ERα splice variant missing exon4, interacts with caveolin-3 and mGluR2/3.
significant decrease in mGluR5 mRNA expression with a resultant increased expression of mGluR3 mRNA expression and hypermethylation of mGluR1 gene across both generations of rats, is reported.
Title: Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure.
studies illustrate the significant contribution of mGluR2 to the antipsychotic-like, sleep and EEG effects of drugs acting on group II mGluRs; however, we also provide evidence of a role for mGluR3 activity in the control of sleep and wake cortical theta and gamma oscillations
Title: Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression.
Results indicate a double function for glial mGlu3R activation against Abeta neurotoxicity: (i) it increases the release of protective neurotrophins such as sAPPalpha and BDNF, and (ii) it induces amyloid removal from extracellular space by glia-mediated phagocytosis.
Title: Amyloid-beta neurotoxicity and clearance are both regulated by glial group II metabotropic glutamate receptors.
Findings suggest a time dependent evolving pattern of mGluR2/3 density during the pathogenesis of mesial temporal lobe epilepsy and provide insights for utilizing this data for in vivo imaging to predict the specific time points and responsiveness to the therapy targeting mGluR2/3.
Title: Metabotropic glutamate receptor 2/3 density and its relation to the hippocampal neuropathology in a model of temporal lobe epilepsy in rats.
Study aimed at further characterizing the effects of prenatal immune activation on 5-HT2A and mGlu2/3 receptor function in male and female rat offspring
Title: Maternal lipopolysaccharide treatment differentially affects 5-HT(2A) and mGlu2/3 receptor function in the adult male and female rat offspring.
This study demonstrated that the Male prenatal chronic mild stress rats expressed significantly higher mGluR2/3 in the prefrontal cortex but lower in female amygalda.
Title: Prenatal chronic mild stress induces depression-like behavior and sex-specific changes in regional glutamate receptor expression patterns in adult rats.
The results of these studies implicate mGlu3 as a major regulator of PFC function and cognition.
Title: Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.
report we describe a novel neuroprotective function of mGlu3 receptors related to their ability to promote the non-amyloidogenic pathway of APP cleavage in astrocytes, thus enhancing sAPPalpha production
Title: Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage.
Following activation of mGluR3 receptors in prefrontal cortex, sensory motor gating deficits were reversed.
Title: Activation of mGluR2/3 receptors in the ventro-rostral prefrontal cortex reverses sensorimotor gating deficits induced by systemic NMDA receptor antagonists.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139646 (e-PCR)
- UniSTS:221730

RH141405 (e-PCR)
- UniSTS:221730

AU027018 (e-PCR)
- UniSTS:113710

RH138123 (e-PCR)
- UniSTS:220210

RH142062 (e-PCR)
- UniSTS:224052

RH144027 (e-PCR)
- UniSTS:233273

WI-18027 (e-PCR)
- UniSTS:15935

RH141561 (e-PCR)
- UniSTS:223555

Grm3 (e-PCR), detects polymorphism
- UniSTS:506954

RH137636 (e-PCR)
- UniSTS:219723

AU026127 (e-PCR)
- UniSTS:116070

RH70765 (e-PCR)
- UniSTS:72048

Grm3 (e-PCR), detects polymorphism
- UniSTS:495991

D4Ulb3 (e-PCR)
- UniSTS:518783

AU028752 (e-PCR)
- UniSTS:112021

D4Wox53 (e-PCR)
- UniSTS:518586

RH140325 (e-PCR)
- UniSTS:222402

RH139066 (e-PCR)
- UniSTS:221152

RH133796 (e-PCR)
- UniSTS:217079

RH142432 (e-PCR)
- UniSTS:231679

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables group II metabotropic glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables group II metabotropic glutamate receptor activity	IEA Inferred from Electronic Annotation more info
enables group II metabotropic glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables group II metabotropic glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to stress	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metabotropic glutamate receptor 3

Names: glutamate receptor, metabotropic 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105712.1 → NP_001099182.1 metabotropic glutamate receptor 3 precursor

See identical proteins and their annotated locations for NP_001099182.1

Status: PROVISIONAL

Source sequence(s)

CH474013

UniProtKB/Swiss-Prot

P31422

UniProtKB/TrEMBL

A6K223

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

25319218..25600721

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285522.1 → XP_063141592.1 metabotropic glutamate receptor 3 isoform X5
XM_039107014.2 → XP_038962942.1 metabotropic glutamate receptor 3 isoform X4

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_039107009.2 → XP_038962937.1 metabotropic glutamate receptor 3 isoform X1

UniProtKB/TrEMBL

A0A8I6GM70

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_039107010.2 → XP_038962938.1 metabotropic glutamate receptor 3 isoform X1

UniProtKB/TrEMBL

A0A8I6GM70

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_039107011.2 → XP_038962939.1 metabotropic glutamate receptor 3 isoform X1

UniProtKB/TrEMBL

A0A8I6GM70

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_039107012.2 → XP_038962940.1 metabotropic glutamate receptor 3 isoform X1

UniProtKB/TrEMBL

A0A8I6GM70

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_008762682.4 → XP_008760904.1 metabotropic glutamate receptor 3 isoform X1

See identical proteins and their annotated locations for XP_008760904.1

UniProtKB/TrEMBL

A0A8I6GM70

Related

ENSRNOP00000007572.7, ENSRNOT00000007572.9

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_039107013.2 → XP_038962941.1 metabotropic glutamate receptor 3 isoform X2

UniProtKB/TrEMBL

A0A0G2JV93

Related

ENSRNOP00000069396.1, ENSRNOT00000089747.3

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_039107015.2 → XP_038962943.1 metabotropic glutamate receptor 3 isoform X3

UniProtKB/Swiss-Prot

P31422

UniProtKB/TrEMBL

A6K223

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_063285521.1 → XP_063141591.1 metabotropic glutamate receptor 3 isoform X3

UniProtKB/Swiss-Prot

P31422

UniProtKB/TrEMBL

A6K223

Related

ENSRNOP00000096683.2, ENSRNOT00000109555.2