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    Fstl4 follistatin-like 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fstl4provided by RGD
    Official Full Name
    follistatin-like 4provided by RGD
    Primary source
    RGD:1307227
    See related
    EnsemblRapid:ENSRNOG00000006565 AllianceGenome:RGD:1307227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable brain-derived neurotrophic factor binding activity. Predicted to be involved in cell differentiation and regulation of BMP signaling pathway. Predicted to act upstream of or within negative regulation of brain-derived neurotrophic factor receptor signaling pathway; negative regulation of collateral sprouting; and negative regulation of dendritic spine development. Predicted to be located in secretory granule. Predicted to be active in extracellular region. Orthologous to human FSTL4 (follistatin like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 21.4), Testes (RPKM 6.3) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fstl4 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (37412288..37845405)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (36911422..37344545)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (38104344..38532216)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548961 Neighboring gene uncharacterized LOC120095321 Neighboring gene uncharacterized LOC134480790 Neighboring gene uncharacterized LOC108352083 Neighboring gene 60S ribosomal protein L14 pseudogene Neighboring gene heat shock protein family A (Hsp70) member 4 Neighboring gene ribosomal protein S2, pseudogene 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SPIG1 negatively regulates BDNF maturation. Suzuki R, et al. J Neurosci, 2014 Feb 26. PMID 24573299, Free PMC Article
    2. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables brain-derived neurotrophic factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT acts_upstream_of_or_within negative regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of brain-derived neurotrophic factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    follistatin-related protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107000.4 → NP_001100470.1  follistatin-related protein 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001100470.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HEB5, D3ZJ81
      Related
      ENSRNOP00000060019.1, ENSRNOT00000067809.3
      Conserved Domains (7) summary
      cd05736
      Location:357 → 432
      Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
      smart00410
      Location:255 → 336
      IG_like; Immunoglobulin like
      cd00104
      Location:92 → 132
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam07679
      Location:340 → 429
      I-set; Immunoglobulin I-set domain
      pfam13499
      Location:178 → 241
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:178 → 242
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl11960
      Location:266 → 322
      Ig; Immunoglobulin domain

    2. NM_001414342.2 → NP_001401271.1  follistatin-related protein 4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZYD0
      Related
      ENSRNOP00000084074.1, ENSRNOT00000116801.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      37412288..37845405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085928.2 → XP_038941856.1  follistatin-related protein 4 isoform X3

      Conserved Domains (1) summary
      cd05736
      Location:26 → 118
      IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

    2. XM_039085927.2 → XP_038941855.1  follistatin-related protein 4 isoform X3

      Conserved Domains (1) summary
      cd05736
      Location:26 → 118
      IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

    3. XM_063268974.1 → XP_063125044.1  follistatin-related protein 4 isoform X2

    4. XM_039085925.2 → XP_038941853.1  follistatin-related protein 4 isoform X1

      Conserved Domains (1) summary
      cd05736
      Location:57 → 149
      IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
    Nucleotide Protein Strain
    Heading Accession and Version

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