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    ARNT aryl hydrocarbon receptor nuclear translocator [ Homo sapiens (human) ]

    Gene ID: 405, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ARNTprovided by HGNC
    Official Full Name
    aryl hydrocarbon receptor nuclear translocatorprovided by HGNC
    Primary source
    HGNC:HGNC:700
    See related
    Ensembl:ENSG00000143437 MIM:126110; AllianceGenome:HGNC:700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARNT1; HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta
    Summary
    This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
    Expression
    Ubiquitous expression in ovary (RPKM 16.9), placenta (RPKM 14.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARNT in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (150809713..150876599, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149933391..150000287, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150782189..150849075, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene short coiled-coil protein pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150753350-150754207 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:150754208-150755064 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150766964 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150774101 Neighboring gene ubiquitin conjugating enzyme E2 D3 pseudogene 3 Neighboring gene cathepsin K Neighboring gene RNA, U6 small nuclear 1309, pseudogene Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150800090 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150800655 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150808889 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150818234 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150822359-150823012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150823013-150823665 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150825511 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150826831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150846639-150847140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150847141-150847640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1306 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:150849134-150849407 Neighboring gene uncharacterized LOC107985204 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150856806 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150858571 Neighboring gene RPS27A pseudogene 6 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150864113 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150864992 Neighboring gene cortexin domain containing 2 Neighboring gene CYCS pseudogene 51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Mandl M, et al. Radiat Oncol, 2015 Nov 16. PMID 26572229, Free PMC Article
    2. The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription. Brunnberg S, et al. Proc Natl Acad Sci U S A, 2003 May 27. PMID 12754377, Free PMC Article
    3. The aryl hydrocarbon receptor nuclear translocator (ARNT) modulates the antioxidant response in AML cells. Gu C, et al. Leuk Res, 2013 Dec. PMID 24220583
    4. Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein. Wilson CL, et al. Arch Biochem Biophys, 1997 Oct 1. PMID 9328285
    5. The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations. Wang XW, et al. Br J Dermatol, 2012 May. PMID 22211302

    See all (311) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
      Title: Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
    2. Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
      Title: Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
    3. Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1beta.
      Title: Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β.
    4. AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity.
      Title: AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity.
    5. The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis.
      Title: The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis.
    6. Hypoxia-inducible factor-1beta is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts.
      Title: Hypoxia-inducible factor-1β is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts.
    7. GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion.
      Title: GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion.
    8. The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor.
      Title: The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor.
    9. Detrimental effects of hypoxia on glomerular podocytes.
      Title: Detrimental effects of hypoxia on glomerular podocytes.
    10. Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene.
      Title: Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene.
    Submit: New GeneRIF Correction See all GeneRIFs (113)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    EBI GWAS Catalog
    Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3.
    EBI GWAS Catalog
    Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA downregulates ARNT gene expression in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables aryl hydrocarbon receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in embryonic placenta development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell proliferation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in positive regulation of erythrocyte differentiation IC
    Inferred by Curator
    more info
    		  
    acts_upstream_of positive regulation of glycolytic process IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in positive regulation of hormone biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in positive regulation of protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of vascular endothelial growth factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of aryl hydrocarbon receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear aryl hydrocarbon receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aryl hydrocarbon receptor nuclear translocator
    Names
    class E basic helix-loop-helix protein 2
    dioxin receptor, nuclear translocator
    hypoxia inducible factor 1 subunit beta
    hypoxia-inducible factor 1, beta subunit

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028248.1 RefSeqGene

      Range
      5170..72056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001197325.2 → NP_001184254.1  aryl hydrocarbon receptor nuclear translocator isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AK291705, AL355860, BU730937
      UniProtKB/TrEMBL
      A8K6P0
      Conserved Domains (5) summary
      smart00091
      Location:151 → 215
      PAS; PAS domain
      cd00130
      Location:347 → 443
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:76 → 128
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:148 → 254
      PAS; PAS fold
      pfam14598
      Location:347 → 447
      PAS_11; PAS domain

    2. NM_001286035.2 → NP_001272964.1  aryl hydrocarbon receptor nuclear translocator isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate exon in the 5' region, initiates translation at a downstream in-frame start codon, and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AK223459, AK293027, AL355860, AL834279, BU730937
      Consensus CDS
      CCDS65641.1
      UniProtKB/TrEMBL
      B0AZM1
      Related
      ENSP00000423851.1, ENST00000515192.5
      Conserved Domains (6) summary
      smart00091
      Location:157 → 221
      PAS; PAS domain
      cd00130
      Location:348 → 444
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:82 → 134
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:154 → 260
      PAS; PAS fold
      pfam11593
      Location:509 → 720
      Med3; Mediator complex subunit 3 fungal
      pfam14598
      Location:348 → 448
      PAS_11; PAS domain

    3. NM_001286036.2 → NP_001272965.1  aryl hydrocarbon receptor nuclear translocator isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AB209877, AK223459, AK293027, AL355860, BU730937
      Consensus CDS
      CCDS65642.1
      UniProtKB/TrEMBL
      B0AZM1
      Related
      ENSP00000346372.2, ENST00000354396.6
      Conserved Domains (3) summary
      cd18947
      Location:86 → 150
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
      pfam00989
      Location:163 → 269
      PAS; PAS fold
      pfam14598
      Location:362 → 462
      PAS_11; PAS domain

    4. NM_001350224.2 → NP_001337153.1  aryl hydrocarbon receptor nuclear translocator isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains an alternate exon in the 5' region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (7) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK293027, AL355860, BC041121, BU730937
      UniProtKB/TrEMBL
      B0AZM1
      Conserved Domains (4) summary
      pfam00010
      Location:82 → 134
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:154 → 260
      PAS; PAS fold
      pfam11593
      Location:514 → 725
      Med3; Mediator complex subunit 3 fungal
      cl25986
      Location:353 → 453
      PAS_3; PAS fold

    5. NM_001350225.2 → NP_001337154.1  aryl hydrocarbon receptor nuclear translocator isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in its 5' coding region, resulting in the use of an alternate start codon, compared to variant 1. The encoded isoform (8) has a slightly shorter, but distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK293027, AL355860, BC041121, BU730937
      UniProtKB/TrEMBL
      B4E3L5
      Conserved Domains (4) summary
      pfam00010
      Location:90 → 142
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:162 → 268
      PAS; PAS fold
      pfam11593
      Location:522 → 733
      Med3; Mediator complex subunit 3 fungal
      cl25986
      Location:361 → 461
      PAS_3; PAS fold

    6. NM_001350226.2 → NP_001337155.1  aryl hydrocarbon receptor nuclear translocator isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate splice site in its 5' coding region, resulting in the use of an alternate start codon, compared to variant 1. The encoded isoform (8) has a slightly shorter, but distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK293027, AL355860, BC041121, BU730937
      UniProtKB/TrEMBL
      B4E3L5
      Conserved Domains (4) summary
      pfam00010
      Location:89 → 141
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:161 → 267
      PAS; PAS fold
      pfam11593
      Location:521 → 732
      Med3; Mediator complex subunit 3 fungal
      cl25986
      Location:360 → 460
      PAS_3; PAS fold

    7. NM_001668.4 → NP_001659.1  aryl hydrocarbon receptor nuclear translocator isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK293027, AL355860, BC041121, BU730937
      Consensus CDS
      CCDS970.1
      UniProtKB/Swiss-Prot
      B2R9H1, C4AMA1, F8WAP6, P27540, Q59ED4, Q5QP39, Q8NDC7
      UniProtKB/TrEMBL
      B0AZM1
      Related
      ENSP00000351407.5, ENST00000358595.10
      Conserved Domains (6) summary
      smart00091
      Location:166 → 230
      PAS; PAS domain
      cd00130
      Location:362 → 458
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:91 → 143
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:163 → 269
      PAS; PAS fold
      pfam11593
      Location:523 → 734
      Med3; Mediator complex subunit 3 fungal
      pfam14598
      Location:362 → 462
      PAS_11; PAS domain

    8. NM_178427.3 → NP_848514.1  aryl hydrocarbon receptor nuclear translocator isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AK315812, AL355860, BU730937
      Consensus CDS
      CCDS971.1
      UniProtKB/TrEMBL
      A8K6P0, B0AZM1
      Related
      ENSP00000427571.1, ENST00000505755.5
      Conserved Domains (6) summary
      smart00091
      Location:151 → 215
      PAS; PAS domain
      cd00130
      Location:347 → 443
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:76 → 128
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:148 → 254
      PAS; PAS fold
      pfam11593
      Location:508 → 719
      Med3; Mediator complex subunit 3 fungal
      pfam14598
      Location:347 → 447
      PAS_11; PAS domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      150809713..150876599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420740.1 → XP_047276696.1  aryl hydrocarbon receptor nuclear translocator isoform X29

      UniProtKB/TrEMBL
      A8K6P0

    2. XM_047420734.1 → XP_047276690.1  aryl hydrocarbon receptor nuclear translocator isoform X28

      UniProtKB/TrEMBL
      A8K6P0

    3. XM_047420716.1 → XP_047276672.1  aryl hydrocarbon receptor nuclear translocator isoform X20

      UniProtKB/TrEMBL
      A8K6P0

    4. XM_047420715.1 → XP_047276671.1  aryl hydrocarbon receptor nuclear translocator isoform X19

      UniProtKB/TrEMBL
      A8K6P0, B0AZM1

    5. XM_047420727.1 → XP_047276683.1  aryl hydrocarbon receptor nuclear translocator isoform X27

      UniProtKB/TrEMBL
      A8K6P0

    6. XM_017001296.2 → XP_016856785.1  aryl hydrocarbon receptor nuclear translocator isoform X26

      UniProtKB/TrEMBL
      A8K6P0

    7. XM_047420719.1 → XP_047276675.1  aryl hydrocarbon receptor nuclear translocator isoform X25

      UniProtKB/TrEMBL
      A8K6P0

    8. XM_017001295.2 → XP_016856784.1  aryl hydrocarbon receptor nuclear translocator isoform X24

      UniProtKB/TrEMBL
      A8K6P0, B0AZM1

    9. XM_047420711.1 → XP_047276667.1  aryl hydrocarbon receptor nuclear translocator isoform X16

      UniProtKB/TrEMBL
      A8K6P0

    10. XM_005245153.2 → XP_005245210.1  aryl hydrocarbon receptor nuclear translocator isoform X15

      UniProtKB/TrEMBL
      B0AZM1
      Conserved Domains (6) summary
      smart00091
      Location:166 → 230
      PAS; PAS domain
      cd00130
      Location:357 → 453
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:91 → 143
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:163 → 269
      PAS; PAS fold
      pfam11593
      Location:518 → 729
      Med3; Mediator complex subunit 3 fungal
      pfam14598
      Location:357 → 457
      PAS_11; PAS domain

    11. XM_017001294.2 → XP_016856783.1  aryl hydrocarbon receptor nuclear translocator isoform X23

      UniProtKB/TrEMBL
      A8K6P0

    12. XM_005245157.2 → XP_005245214.1  aryl hydrocarbon receptor nuclear translocator isoform X22

      UniProtKB/TrEMBL
      A8K6P0, B0AZM1
      Conserved Domains (6) summary
      smart00091
      Location:166 → 230
      PAS; PAS domain
      cd00130
      Location:362 → 458
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:91 → 143
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:163 → 269
      PAS; PAS fold
      pfam11593
      Location:486 → 697
      Med3; Mediator complex subunit 3 fungal
      pfam14598
      Location:362 → 462
      PAS_11; PAS domain

    13. XM_005245151.3 → XP_005245208.1  aryl hydrocarbon receptor nuclear translocator isoform X12

      UniProtKB/TrEMBL
      A8K6P0
      Conserved Domains (5) summary
      smart00091
      Location:166 → 230
      PAS; PAS domain
      cd00130
      Location:362 → 458
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:91 → 143
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:163 → 269
      PAS; PAS fold
      pfam14598
      Location:362 → 462
      PAS_11; PAS domain

    14. XM_047420697.1 → XP_047276653.1  aryl hydrocarbon receptor nuclear translocator isoform X7

      UniProtKB/TrEMBL
      A8K6P0

    15. XM_047420694.1 → XP_047276650.1  aryl hydrocarbon receptor nuclear translocator isoform X6

      UniProtKB/TrEMBL
      A8K6P0, B0AZM1

    16. XM_017001293.2 → XP_016856782.1  aryl hydrocarbon receptor nuclear translocator isoform X11

      UniProtKB/TrEMBL
      A8K6P0

    17. XM_047420701.1 → XP_047276657.1  aryl hydrocarbon receptor nuclear translocator isoform X10

      UniProtKB/TrEMBL
      A8K6P0

    18. XM_017001291.2 → XP_016856780.1  aryl hydrocarbon receptor nuclear translocator isoform X5

      UniProtKB/TrEMBL
      A8K6P0

    19. XM_017001290.3 → XP_016856779.1  aryl hydrocarbon receptor nuclear translocator isoform X4

      UniProtKB/TrEMBL
      A8K6P0, B0AZM1

    20. XM_047420692.1 → XP_047276648.1  aryl hydrocarbon receptor nuclear translocator isoform X3

      UniProtKB/TrEMBL
      A8K6P0

    21. XM_017001289.2 → XP_016856778.1  aryl hydrocarbon receptor nuclear translocator isoform X2

      UniProtKB/TrEMBL
      B0AZM1
      Conserved Domains (6) summary
      smart00091
      Location:157 → 221
      PAS; PAS domain
      cd00130
      Location:348 → 444
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:82 → 134
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:154 → 260
      PAS; PAS fold
      pfam11593
      Location:509 → 720
      Med3; Mediator complex subunit 3 fungal
      pfam14598
      Location:348 → 448
      PAS_11; PAS domain

    22. XM_047420700.1 → XP_047276656.1  aryl hydrocarbon receptor nuclear translocator isoform X9

      UniProtKB/TrEMBL
      A8K6P0

    23. XM_017001292.2 → XP_016856781.1  aryl hydrocarbon receptor nuclear translocator isoform X8

      UniProtKB/TrEMBL
      A8K6P0, B0AZM1

    24. XM_017001288.3 → XP_016856777.1  aryl hydrocarbon receptor nuclear translocator isoform X1

      UniProtKB/TrEMBL
      A8K6P0

    25. XM_047420713.1 → XP_047276669.1  aryl hydrocarbon receptor nuclear translocator isoform X18

      UniProtKB/TrEMBL
      B4E3L5

    26. XM_047420709.1 → XP_047276665.1  aryl hydrocarbon receptor nuclear translocator isoform X14

      UniProtKB/TrEMBL
      B4E3L5

    27. XM_047420743.1 → XP_047276699.1  aryl hydrocarbon receptor nuclear translocator isoform X30

      UniProtKB/TrEMBL
      B4E3L5

    28. XM_047420712.1 → XP_047276668.1  aryl hydrocarbon receptor nuclear translocator isoform X17

      UniProtKB/TrEMBL
      B4E3L5

    29. XM_011509543.4 → XP_011507845.1  aryl hydrocarbon receptor nuclear translocator isoform X13

      UniProtKB/TrEMBL
      B4E3L5
      Conserved Domains (4) summary
      pfam00010
      Location:90 → 142
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:162 → 268
      PAS; PAS fold
      pfam11593
      Location:522 → 733
      Med3; Mediator complex subunit 3 fungal
      cl25986
      Location:361 → 461
      PAS_3; PAS fold

    30. XM_011509546.3 → XP_011507848.1  aryl hydrocarbon receptor nuclear translocator isoform X21

      UniProtKB/TrEMBL
      B0AZM1
      Conserved Domains (6) summary
      smart00091
      Location:134 → 198
      PAS; PAS domain
      cd00130
      Location:330 → 426
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:59 → 111
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:131 → 237
      PAS; PAS fold
      pfam11593
      Location:491 → 702
      Med3; Mediator complex subunit 3 fungal
      pfam14598
      Location:330 → 430
      PAS_11; PAS domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      149933391..150000287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336623.1 → XP_054192598.1  aryl hydrocarbon receptor nuclear translocator isoform X29

      UniProtKB/TrEMBL
      A8K6P0

    2. XM_054336622.1 → XP_054192597.1  aryl hydrocarbon receptor nuclear translocator isoform X28

      UniProtKB/TrEMBL
      A8K6P0

    3. XM_054336614.1 → XP_054192589.1  aryl hydrocarbon receptor nuclear translocator isoform X20

      UniProtKB/TrEMBL
      A8K6P0

    4. XM_054336613.1 → XP_054192588.1  aryl hydrocarbon receptor nuclear translocator isoform X19

      UniProtKB/TrEMBL
      A8K6P0, B0AZM1

    5. XM_054336621.1 → XP_054192596.1  aryl hydrocarbon receptor nuclear translocator isoform X27

      UniProtKB/TrEMBL
      A8K6P0

    6. XM_054336620.1 → XP_054192595.1  aryl hydrocarbon receptor nuclear translocator isoform X26

      UniProtKB/TrEMBL
      A8K6P0

    7. XM_054336619.1 → XP_054192594.1  aryl hydrocarbon receptor nuclear translocator isoform X25

      UniProtKB/TrEMBL
      A8K6P0

    8. XM_054336618.1 → XP_054192593.1  aryl hydrocarbon receptor nuclear translocator isoform X24

      UniProtKB/TrEMBL
      A8K6P0, B0AZM1

    9. XM_054336610.1 → XP_054192585.1  aryl hydrocarbon receptor nuclear translocator isoform X16

      UniProtKB/TrEMBL
      A8K6P0

    10. XM_054336609.1 → XP_054192584.1  aryl hydrocarbon receptor nuclear translocator isoform X15

      UniProtKB/TrEMBL
      B0AZM1

    11. XM_054336617.1 → XP_054192592.1  aryl hydrocarbon receptor nuclear translocator isoform X23

      UniProtKB/TrEMBL
      A8K6P0

    12. XM_054336616.1 → XP_054192591.1  aryl hydrocarbon receptor nuclear translocator isoform X22

      UniProtKB/TrEMBL
      A8K6P0, B0AZM1

    13. XM_054336608.1 → XP_054192583.1  aryl hydrocarbon receptor nuclear translocator isoform X12

      UniProtKB/TrEMBL
      A8K6P0

    14. XM_054336603.1 → XP_054192578.1  aryl hydrocarbon receptor nuclear translocator isoform X7

      UniProtKB/TrEMBL
      A8K6P0

    15. XM_054336602.1 → XP_054192577.1  aryl hydrocarbon receptor nuclear translocator isoform X6

      UniProtKB/TrEMBL
      A8K6P0, B0AZM1

    16. XM_054336607.1 → XP_054192582.1  aryl hydrocarbon receptor nuclear translocator isoform X11

      UniProtKB/TrEMBL
      A8K6P0

    17. XM_054336606.1 → XP_054192581.1  aryl hydrocarbon receptor nuclear translocator isoform X10

      UniProtKB/TrEMBL
      A8K6P0

    18. XM_054336601.1 → XP_054192576.1  aryl hydrocarbon receptor nuclear translocator isoform X5

      UniProtKB/TrEMBL
      A8K6P0

    19. XM_054336600.1 → XP_054192575.1  aryl hydrocarbon receptor nuclear translocator isoform X4

      UniProtKB/TrEMBL
      A8K6P0, B0AZM1

    20. XM_054336599.1 → XP_054192574.1  aryl hydrocarbon receptor nuclear translocator isoform X3

      UniProtKB/TrEMBL
      A8K6P0

    21. XM_054336598.1 → XP_054192573.1  aryl hydrocarbon receptor nuclear translocator isoform X2

      UniProtKB/TrEMBL
      B0AZM1

    22. XM_054336605.1 → XP_054192580.1  aryl hydrocarbon receptor nuclear translocator isoform X9

      UniProtKB/TrEMBL
      A8K6P0

    23. XM_054336604.1 → XP_054192579.1  aryl hydrocarbon receptor nuclear translocator isoform X8

      UniProtKB/TrEMBL
      A8K6P0, B0AZM1

    24. XM_054336597.1 → XP_054192572.1  aryl hydrocarbon receptor nuclear translocator isoform X1

      UniProtKB/TrEMBL
      A8K6P0

    25. XM_054336612.1 → XP_054192587.1  aryl hydrocarbon receptor nuclear translocator isoform X18

      UniProtKB/TrEMBL
      B4E3L5

    26. XM_054336624.1 → XP_054192599.1  aryl hydrocarbon receptor nuclear translocator isoform X30

      UniProtKB/TrEMBL
      B4E3L5

    27. XM_054336611.1 → XP_054192586.1  aryl hydrocarbon receptor nuclear translocator isoform X17

      UniProtKB/TrEMBL
      B4E3L5

    28. XM_054336615.1 → XP_054192590.1  aryl hydrocarbon receptor nuclear translocator isoform X21

      UniProtKB/TrEMBL
      B0AZM1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178426.1: Suppressed sequence

      Description
      NM_178426.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27540.1 GenPept UniProtKB/Swiss-Prot:P27540

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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