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    SPACA4 sperm acrosome associated 4 [ Homo sapiens (human) ]

    Gene ID: 171169, updated on 27-Dec-2024

    Summary

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    Official Symbol
    SPACA4provided by HGNC
    Official Full Name
    sperm acrosome associated 4provided by HGNC
    Primary source
    HGNC:HGNC:16441
    See related
    Ensembl:ENSG00000177202 MIM:609932; AllianceGenome:HGNC:16441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAMP14
    Summary
    Involved in binding activity of sperm to zona pellucida. Located in inner acrosomal membrane and outer acrosomal membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    mouse all
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    Genomic context

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    See SPACA4 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48606742..48607714)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51600842..51601814)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49109999..49110971)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48993225-48993796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10882 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10884 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48996420-48996611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10886 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48997173-48997673 Neighboring gene lemur tyrosine kinase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10887 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10888 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49017633-49017779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49046825-49047364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49048751-49049694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49054849-49055373 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49057162-49058100 Neighboring gene sulfotransferase family 2B member 1 Neighboring gene Sharpr-MPRA regulatory regions 10218 and 12364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14898 Neighboring gene family with sequence similarity 83 member E Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49117268-49117444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49117749-49118580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49118581-49119412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49119413-49120243 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:49121076-49121906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14903 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10889 Neighboring gene Sharpr-MPRA regulatory region 2382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49130943-49131443 Neighboring gene ribosomal protein L18 Neighboring gene sphingosine kinase 2 Neighboring gene D-box binding PAR bZIP transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spermatogenic cell-specific SPACA4 is essential for efficient sperm-zona pellucida binding in vitro. Chen L, et al. Front Cell Dev Biol, 2023. PMID 37377732, Free PMC Article
    2. SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction. Shetty J, et al. J Biol Chem, 2003 Aug 15. PMID 12788941
    3. The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization. Herberg S, et al. Science, 2018 Sep 7. PMID 30190407, Free PMC Article
    4. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
    5. Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies. Schiza C, et al. Mol Cell Proteomics, 2018 Dec. PMID 30097533, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SAMP14 represents a GPI-anchored putative receptor in the Ly-6/uPAR family that is exposed on the inner acrosomal membrane after the acrosome reaction.
      Title: SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm-egg recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in inner acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sperm acrosome membrane-associated protein 4
    Names
    sperm acrosomal membrane protein 14
    sperm acrosomal membrane-associated protein 14
    testicular tissue protein Li 167

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133498.3 → NP_598005.1  sperm acrosome membrane-associated protein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC022154, AF353721
      Consensus CDS
      CCDS12725.1
      UniProtKB/Swiss-Prot
      Q8TDM5
      UniProtKB/TrEMBL
      A0A140VJU1
      Related
      ENSP00000312774.1, ENST00000321762.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      48606742..48607714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      51600842..51601814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDM5.1 GenPept UniProtKB/Swiss-Prot:Q8TDM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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