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    gw gawky [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43808, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gwprovided by FlyBase
    Official Full Name
    gawkyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051992
    Locus tag
    Dmel_CG31992
    See related
    AllianceGenome:FB:FBgn0051992
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey205; CG11484; CG31992; CG9905; dGW182; Dmel\CG31992; GQ182; Gw; GW; gw182; Gw182; GW182
    Summary
    Predicted to enable nucleic acid binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; locomotor rhythm; and negative regulation of gene expression. Located in P-body. Part of RISC complex. Is expressed in adult head and male germline cyst. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 6; subserous uterine fibroid; and uterine fibroid. Orthologous to several human genes including TNRC6C (trinucleotide repeat containing adaptor 6C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    102D2-102D3; 4-0 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (649041..660608, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (669667..683729, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene GABA transporter Neighboring gene pseudo Neighboring gene Eye-enriched kainate receptor Neighboring gene uncharacterized protein Neighboring gene SLo interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gawky (GW) is the Drosophila melanogaster GW182 homologue. Li J, et al. Adv Exp Med Biol, 2013. PMID 23224968
    2. Cytoplasmically localized tRNA-derived fragments inhibit translation in Drosophila S2 cells. Hamid SM, et al. Turk J Biol, 2022. PMID 37529257, Free PMC Article
    3. Gawky modulates MTF-1-mediated transcription activation and metal discrimination. Jia R, et al. Nucleic Acids Res, 2021 Jun 21. PMID 34107019, Free PMC Article
    4. The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression. Chekulaeva M, et al. Nucleic Acids Res, 2010 Oct. PMID 20530530, Free PMC Article
    5. FMRP cooperates with miRISC components to repress translation and regulate neurite morphogenesis in Drosophila. Kaul N, et al. RNA Biol, 2024 Jan. PMID 39190491, Free PMC Article

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A circular RNA-gawky-chromatin regulatory axis modulates stress-induced transcription.
      Title: A circular RNA-gawky-chromatin regulatory axis modulates stress-induced transcription.
    2. Gawky modulates MTF-1-mediated transcription activation and metal discrimination.
      Title: Gawky modulates MTF-1-mediated transcription activation and metal discrimination.
    3. This study demonistryed that GW182's gene silencing activity functions as a rheostat for PDFR signaling and thus profoundly impacts the circadian neural network and its response to environmental inputs.
      Title: GW182 controls Drosophila circadian behavior and PDF-receptor signaling.
    4. miRNA-mediated translational repression and degradation are mechanistically linked and are triggered through the interactions of GW182 with poly(A)-binding protein and deadenylases.
      Title: The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.
    5. Gawky plays a critical role in miRNA-mediated gene silencing. (Review)
      Title: Gawky (GW) is the Drosophila melanogaster GW182 homologue.
    6. MicroRNAs utilize at least three distinct silencing pathways: GW182-mediated deadenylation and GW182-dependent and -independent repression of early translation initiation.
      Title: MicroRNAs mediate gene silencing via multiple different pathways in drosophila.
    7. Data demonstrate that in human and Drosophila melanogaster cells, the critical repressive features of both the N-terminal and C-terminal effector domains of GW182 proteins are Gly/Ser/Thr-Trp (G/S/TW) or Trp-Gly/Ser/Thr (WG/S/T) motifs.
      Title: miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs.
    8. HPat binds to and copurifies with GW182.
      Title: The decapping activator HPat a novel factor co-purifying with GW182 from Drosophila cells.
    9. Multiple GW/WG repeats present in the minimal N-terminal repressor domain of Drosophila GW182 are required for target mRNA repression.
      Title: The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression.
    10. model proposed in which the GW182 silencing domain promotes translational repression, at least in part, by interfering with mRNA circularization and also recruits the deadenylase complex through the interaction with PABPC1
      Title: The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c653382-653247 mobile_element_type = transposon:INE-1{}1941

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in embryonic development via the syncytial blastoderm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in miRNA-mediated gene silencing by inhibition of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in miRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RISC complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gawky
    Names
    CG31992-PA
    CG31992-PB
    CG31992-PE
    CG31992-PF
    CG31992-PJ
    gawki
    gw-PA
    gw-PB
    gw-PE
    gw-PF
    gw-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      649041..660608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014691.3 → NP_001014691.2  gawky, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014691.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SY33
      Conserved Domains (5) summary
      cd12435
      Location:1114 → 1183
      RRM_GW182_like; RNA recognition motif in the GW182 family proteins
      cd14284
      Location:551 → 585
      UBA_GAWKY; UBA domain found in Drosophila melanogaster protein Gawky (GW) and similar proteins
      pfam10427
      Location:388 → 520
      Ago_hook; Argonaute hook
      pfam12938
      Location:613 → 848
      M_domain; M domain of GW182
      pfam16608
      Location:844 → 1066
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    2. NM_166781.2 → NP_726597.1  gawky, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSF0, Q8SY33, Q9V4F1
      Related
      FBpp0088165
      Conserved Domains (5) summary
      cd12435
      Location:1116 → 1185
      RRM_GW182_like; RNA recognition motif in the GW182 family proteins
      cd14284
      Location:551 → 585
      UBA_GAWKY; UBA domain found in Drosophila melanogaster protein Gawky (GW) and similar proteins
      pfam10427
      Location:388 → 520
      Ago_hook; Argonaute hook
      pfam12938
      Location:613 → 848
      M_domain; M domain of GW182
      pfam16608
      Location:844 → 1068
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    3. NM_166784.2 → NP_726600.1  gawky, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726600.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSF0, Q8SY33, Q9V4F1
      Related
      FBpp0088166
      Conserved Domains (5) summary
      cd12435
      Location:1116 → 1185
      RRM_GW182_like; RNA recognition motif in the GW182 family proteins
      cd14284
      Location:551 → 585
      UBA_GAWKY; UBA domain found in Drosophila melanogaster protein Gawky (GW) and similar proteins
      pfam10427
      Location:388 → 520
      Ago_hook; Argonaute hook
      pfam12938
      Location:613 → 848
      M_domain; M domain of GW182
      pfam16608
      Location:844 → 1068
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    4. NM_166785.2 → NP_726601.1  gawky, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726601.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSF0, Q8SY33, Q9V4F1
      Related
      FBpp0088170
      Conserved Domains (5) summary
      cd12435
      Location:1116 → 1185
      RRM_GW182_like; RNA recognition motif in the GW182 family proteins
      cd14284
      Location:551 → 585
      UBA_GAWKY; UBA domain found in Drosophila melanogaster protein Gawky (GW) and similar proteins
      pfam10427
      Location:388 → 520
      Ago_hook; Argonaute hook
      pfam12938
      Location:613 → 848
      M_domain; M domain of GW182
      pfam16608
      Location:844 → 1068
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    5. NM_166780.2 → NP_726596.1  gawky, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726596.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSF0, Q8SY33, Q9V4F1
      Related
      FBpp0088169
      Conserved Domains (5) summary
      cd12435
      Location:1116 → 1185
      RRM_GW182_like; RNA recognition motif in the GW182 family proteins
      cd14284
      Location:551 → 585
      UBA_GAWKY; UBA domain found in Drosophila melanogaster protein Gawky (GW) and similar proteins
      pfam10427
      Location:388 → 520
      Ago_hook; Argonaute hook
      pfam12938
      Location:613 → 848
      M_domain; M domain of GW182
      pfam16608
      Location:844 → 1068
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SY33.1 Q8SY33

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