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    CG6839 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40067, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6839provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036831
    Locus tag
    Dmel_CG6839
    See related
    AllianceGenome:FB:FBgn0036831
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6839
    Summary
    Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6839 in Genome Data Viewer
    Location:
    75E5-75E6; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18917581..18919259)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18910681..18912359)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 1b Neighboring gene pre-mRNA processing factor 6 Neighboring gene Cytochrome c oxidase subunit 6A-like 2 Neighboring gene Ionotropic receptor 75d Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of hunger-driven gene expression in the Drosophila melanogaster larval central nervous system. Ryuda M, et al. Zoolog Sci, 2008 Jul. PMID 18828662
    2. Temporal Exposure to Bt Insecticide Causes Oxidative Stress in Larval Midgut Tissue. Muita BK, et al. Toxins (Basel), 2023 May 7. PMID 37235357, Free PMC Article
    3. Drosophila p53 directs nonapoptotic programs in postmitotic tissue. Kurtz P, et al. Mol Biol Cell, 2019 May 15. PMID 30892991, Free PMC Article
    4. Seizure suppression by gain-of-function escargot mutations. Hekmat-Scafe DS, et al. Genetics, 2005 Mar. PMID 15654097, Free PMC Article
    5. The gut microbiome participates in transgenerational inheritance of low-temperature responses in Drosophila melanogaster. Zare A, et al. FEBS Lett, 2018 Dec. PMID 30372516, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6839-PA
    NP_649076.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18917581..18919259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140819.2 → NP_649076.1  uncharacterized protein Dmel_CG6839 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649076.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVU9
      Related
      FBpp0074836
      Conserved Domains (1) summary
      cd00091
      Location:170 → 420
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TI9 Q95TI9
    Q9VVU9 Q9VVU9

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