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    Tmhs Tetraspan membrane protein in hair cell stereocilia [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38251, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmhsprovided by FlyBase
    Official Full Name
    Tetraspan membrane protein in hair cell stereociliaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262624
    Locus tag
    Dmel_CG12026
    See related
    AllianceGenome:FB:FBgn0262624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12026; Dmel\CG12026; TMHS
    Summary
    Involved in sensory perception of sound. Predicted to be active in plasma membrane. Is expressed in several structures, including dorsal ectoderm anlage; embryonic anal pad; embryonic hypopharynx; embryonic large intestine; and gut section. Used to study autosomal recessive nonsyndromic deafness 67. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 67. Orthologous to several human genes including LHFPL4 (LHFPL tetraspan subfamily member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tmhs in Genome Data Viewer
    Location:
    62B9-62B9; 3-1.0 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1885657..1891462)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1885657..1891462)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Adenine phosphoribosyltransferase Neighboring gene debris buster Neighboring gene transfer RNA:Cysteine-GCA 2-1 Neighboring gene Dbx

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unique transgenic animal model for hereditary hearing loss. Cosetti M, et al. Ann Otol Rhinol Laryngol, 2008 Nov. PMID 19102128, Free PMC Article
    2. The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control. Nelson KS, et al. Genetics, 2010 Jul. PMID 20407131, Free PMC Article
    3. The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development. Rice C, et al. Genetics, 2020 Dec. PMID 33115752, Free PMC Article
    4. Impact of gut microbiota on the fly's germ line. Elgart M, et al. Nat Commun, 2016 Apr 15. PMID 27080728, Free PMC Article
    5. Spotted-dick, a zinc-finger protein of Drosophila required for expression of Orc4 and S phase. Page AR, et al. EMBO J, 2005 Dec 21. PMID 16369566, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 1886389-1886427 mobile_element_type = transposon:Doc2{}3998

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspan membrane protein in hair cell stereocilia
    Names
    CG12026-PA
    CG12026-PB
    Tmhs-PA
    Tmhs-PB
    tetraspan membrane protein in hair cell stereocilia ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1885657..1891462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167926.3 → NP_728691.1  tetraspan membrane protein in hair cell stereocilia, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728691.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W068
      Related
      FBpp0072716
      Conserved Domains (1) summary
      pfam10242
      Location:25 → 199
      L_HGMIC_fpl; Lipoma HMGIC fusion partner-like protein

    2. NM_139417.3 → NP_647674.1  tetraspan membrane protein in hair cell stereocilia, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W068
      Related
      FBpp0072717
      Conserved Domains (1) summary
      pfam10242
      Location:25 → 199
      L_HGMIC_fpl; Lipoma HMGIC fusion partner-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W068 Q9W068

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