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    Sodh1 Sorbitol dehydrogenase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sodh1provided by FlyBase
    Official Full Name
    Sorbitol dehydrogenase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0024289
    Locus tag
    Dmel_CG1982
    See related
    AllianceGenome:FB:FBgn0024289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00464.2; CG1982; Dmel\CG1982; DM_7298873; Sdh-1; Sodh; Sodh-1
    Summary
    Enables L-iditol 2-dehydrogenase (NAD+) activity. Involved in fructose biosynthetic process and sorbitol catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; amnioserosa; dorsal ectoderm anlage; and ectoderm anlage. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sodh1 in Genome Data Viewer
    Location:
    84B2-84B2; 3-48 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7052335..7054541)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2878057..2880263)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45899 Neighboring gene long non-coding RNA:CR44933 Neighboring gene uncharacterized protein Neighboring gene don juan

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sorbitol dehydrogenase of Drosophila. Gene, protein, and expression data show a two-gene system. Luque T, et al. J Biol Chem, 1998 Dec 18. PMID 9852094
    2. Sorbitol reduction via govorestat ameliorates synaptic dysfunction and neurodegeneration in sorbitol dehydrogenase deficiency. Zhu Y, et al. JCI Insight, 2023 May 22. PMID 37014713, Free PMC Article
    3. Biallelic mutations in SORD cause a common and potentially treatable hereditary neuropathy with implications for diabetes. Cortese A, et al. Nat Genet, 2020 May. PMID 32367058, Free PMC Article
    4. Neural control of redox response and microbiota-triggered inflammation in Drosophila gut. Fuse N, et al. Front Immunol, 2023. PMID 37965334, Free PMC Article
    5. A basal transcription factor that activates or represses transcription. Willy PJ, et al. Science, 2000 Nov 3. PMID 11062130

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables D-xylulose reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-iditol 2-dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-iditol 2-dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fructose biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sorbitol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sorbitol catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in xylitol catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sorbitol dehydrogenase 1
    Names
    CG1982-PA
    CG1982-PB
    Sodh1-PA
    Sodh1-PB
    sorbitol dehydrogenase
    sorbitol dehydrogenase like
    NP_001287203.1
    NP_477348.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7052335..7054541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058000.3 → NP_477348.1  sorbitol dehydrogenase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477348.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97479, Q960H1
      Related
      FBpp0081141
      Conserved Domains (2) summary
      cd05285
      Location:8 → 349
      sorbitol_DH; Sorbitol dehydrogenase
      PLN02702
      Location:4 → 346
      PLN02702; L-idonate 5-dehydrogenase

    2. NM_001300274.1 → NP_001287203.1  sorbitol dehydrogenase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97479, Q960H1
      Conserved Domains (2) summary
      cd05285
      Location:8 → 349
      sorbitol_DH; Sorbitol dehydrogenase
      PLN02702
      Location:4 → 346
      PLN02702; L-idonate 5-dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97479 O97479
    Q960H1 Q960H1

    Gene LinkOut

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