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    Wdr59 WD repeat domain 59 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr59provided by FlyBase
    Official Full Name
    WD repeat domain 59provided by FlyBase
    Primary source
    FLYBASE:FBgn0032339
    Locus tag
    Dmel_CG4705
    See related
    AllianceGenome:FB:FBgn0032339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4705; Dmel\CG4705; FBtr0080196; GATOR2; Sea3; SEA3; wdr5; wdr59; WDR59
    Summary
    Predicted to enable signaling adaptor activity. Involved in cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of TORC1 signaling. Part of GATOR2 complex. Is expressed in adult head. Orthologous to human WDR59 (WD repeat domain 59). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Wdr59 in Genome Data Viewer
    Location:
    32D2-32D3; 2-44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11091444..11095096)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11091444..11095096)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Allatostatin double C Neighboring gene uncharacterized protein Neighboring gene Ge-1 Neighboring gene RALBP1 associated Eps domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The minimal interspecific introgression resulting in male sterility in Drosophila. Sawamura K, et al. Genet Res, 2004 Oct. PMID 15678745
    2. Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. Gu X, et al. Nature, 2022 Aug. PMID 35859173, Free PMC Article
    3. Wdr59 promotes or inhibits TORC1 activity depending on cellular context. Zhang Y, et al. Proc Natl Acad Sci U S A, 2023 Jan 3. PMID 36577058, Free PMC Article
    4. An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway. Liu GY, et al. Nat Commun, 2024 Mar 21. PMID 38514639, Free PMC Article
    5. The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function. Cai W, et al. PLoS Genet, 2016 May. PMID 27166823, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wdr59 promotes or inhibits TORC1 activity depending on cellular context.
      Title: Wdr59 promotes or inhibits TORC1 activity depending on cellular context.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GATOR2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GATOR2 complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of Seh1-associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Seh1-associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Seh1-associated complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat domain 59
    Names
    CG4705-PB
    CG4705-PD
    Wdr59-PB
    Wdr59-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11091444..11095096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135641.4 → NP_609485.4  WD repeat domain 59, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609485.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RIT6, Q7KTE5, Q8T9F8, Q9VKK2
      Conserved Domains (3) summary
      COG2319
      Location:92 → 343
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:132 → 170
      7WD40; WD40 repeat [structural motif]
      cd16692
      Location:912 → 957
      mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins

    2. NM_205960.4 → NP_995682.1  WD repeat domain 59, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995682.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RIT6, Q7KTE5, Q8T9F8, Q9VKK2
      Conserved Domains (3) summary
      COG2319
      Location:92 → 343
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:132 → 170
      7WD40; WD40 repeat [structural motif]
      cd16692
      Location:912 → 957
      mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKK2.3 Q9VKK2

    Gene LinkOut

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