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    regucalcin regucalcin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32165, updated on 9-Dec-2024

    Summary

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    Official Symbol
    regucalcinprovided by FlyBase
    Official Full Name
    regucalcinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030362
    Locus tag
    Dmel_CG1803
    See related
    AllianceGenome:FB:FBgn0030362
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1803; Dmel\CG1803; Regucalcin; RgN; T1
    Summary
    Enables serine hydrolase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; amnioserosa; dorsal pharyngeal muscle primordium; and larval somatic muscle cell. Orthologous to human RGN (regucalcin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See regucalcin in Genome Data Viewer
    Location:
    11A1-11A1; 1-38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12012377..12017375)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11906410..11911408)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene furrowed Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chromatin accessibility complex 16kD protein Neighboring gene LSM12 homolog a Neighboring gene Transport and Golgi organization 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Photoperiodic regulation of cold tolerance and expression levels of regucalcin gene in Drosophila montana. Vesala L, et al. J Insect Physiol, 2012 May. PMID 22360999
    2. Identification and characterization of an anterior fat body protein in an insect. Nakajima Y, et al. J Biochem, 2000 May. PMID 10788801
    3. The Dca gene involved in cold adaptation in Drosophila melanogaster arose by duplication of the ancestral regucalcin gene. Arboleda-Bustos CE, et al. Mol Biol Evol, 2011 Aug. PMID 21339509
    4. A comparative study of the short term cold resistance response in distantly related Drosophila species: the role of regucalcin and frost. Reis M, et al. PLoS One, 2011. PMID 21991316, Free PMC Article
    5. Advances in Novel Animal Vitamin C Biosynthesis Pathways and the Role of Prokaryote-Based Inferences to Understand Their Origin. Duque P, et al. Genes (Basel), 2022 Oct 21. PMID 36292802, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gluconolactonase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in L-ascorbic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular space HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regucalcin
    Names
    CG1803-PA
    CG1803-PB
    CG1803-PC
    CG1803-PD
    regucalcin-PA
    regucalcin-PB
    regucalcin-PC
    regucalcin-PD
    NP_572775.1
    NP_727586.1
    NP_727587.1
    NP_727588.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12012377..12017375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167314.2 → NP_727586.1  regucalcin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP78, Q9VYR1
      Related
      FBpp0073419
      Conserved Domains (3) summary
      cd05819
      Location:213 → 243
      NHL; NHL repeat [structural motif]
      pfam08450
      Location:15 → 274
      SGL; SMP-30/Gluconolaconase/LRE-like region
      cl18310
      Location:213 → 286
      NHL; NHL repeat unit of beta-propeller proteins

    2. NM_132547.3 → NP_572775.1  regucalcin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572775.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP78, Q9VYR1
      Related
      FBpp0073420
      Conserved Domains (3) summary
      cd05819
      Location:213 → 243
      NHL; NHL repeat [structural motif]
      pfam08450
      Location:15 → 274
      SGL; SMP-30/Gluconolaconase/LRE-like region
      cl18310
      Location:213 → 286
      NHL; NHL repeat unit of beta-propeller proteins

    3. NM_167315.2 → NP_727587.1  regucalcin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP78, Q9VYR1
      Related
      FBpp0073421
      Conserved Domains (3) summary
      cd05819
      Location:213 → 243
      NHL; NHL repeat [structural motif]
      pfam08450
      Location:15 → 274
      SGL; SMP-30/Gluconolaconase/LRE-like region
      cl18310
      Location:213 → 286
      NHL; NHL repeat unit of beta-propeller proteins

    4. NM_167316.2 → NP_727588.2  regucalcin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727588.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP78, Q76NR6
      Related
      FBpp0073422
      Conserved Domains (3) summary
      cd05819
      Location:229 → 259
      NHL; NHL repeat [structural motif]
      pfam08450
      Location:31 → 290
      SGL; SMP-30/Gluconolaconase/LRE-like region
      cl18310
      Location:229 → 302
      NHL; NHL repeat unit of beta-propeller proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76NR6 Q76NR6
    Q9VYR1 Q9VYR1

    Gene LinkOut

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