U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sulf1 Sulfated [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53437, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sulf1provided by FlyBase
    Official Full Name
    Sulfatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040271
    Locus tag
    Dmel_CG6725
    See related
    AllianceGenome:FB:FBgn0040271
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6725; Dmel\CG6725; DSulf; Dsulf1; DSulf1; Neu5; sulf; Sulf-1; sulf1
    Summary
    Enables N-acetylglucosamine-6-sulfatase activity. Involved in several processes, including neuron development; regulation of signal transduction; and wing disc pattern formation. Located in extracellular space. Is expressed in several structures, including CNS glial cell; ganglia; gut section; head epidermis primordium; and presumptive wing vein. Orthologous to human SULF1 (sulfatase 1) and SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sulf1 in Genome Data Viewer
    Location:
    89B12-89B13; 3-58 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16310542..16339575, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12136264..12165297, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene gilgamesh Neighboring gene Zinc/iron regulated transporter-related protein 89B Neighboring gene transfer RNA:Phenylalanine-GAA 1-8 Neighboring gene transfer RNA:Valine-AAC 1-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Splicing factor 2 Neighboring gene uncharacterized protein Neighboring gene poils au dos Neighboring gene uncharacterized protein Neighboring gene Mesencephalic astrocyte-derived neurotrophic factor

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Differential heparan sulfate dependency of the Drosophila glypicans. Nakato E, et al. J Biol Chem, 2024 Jan. PMID 38072044, Free PMC Article
    2. Drosophila heparan sulfate 6-O-endosulfatase Sulf1 facilitates wingless (Wg) protein degradation. Kleinschmit A, et al. J Biol Chem, 2013 Feb 15. PMID 23300081, Free PMC Article
    3. The role of Drosophila heparan sulfate 6-O-endosulfatase in sulfation compensation. Dejima K, et al. J Biol Chem, 2013 Mar 1. PMID 23339195, Free PMC Article
    4. The Drosophila Hox gene Ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connections. Hessinger C, et al. Development, 2017 Jan 1. PMID 27913640, Free PMC Article
    5. Heparan sulfate regulates the number and centrosome positioning of Drosophila male germline stem cells. Levings DC, et al. Mol Biol Cell, 2016 Mar 15. PMID 26792837, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sulf1 is required for terminating intestinal stem cell division at the end of regeneration.
      Title: Drosophila Sulf1 is required for the termination of intestinal stem cell division during regeneration.
    2. vertebrate and Drosophila Sulfs have an intrinsically similar activity and the function of Sulfs in the fate of Wnt/Wg ligands is context-dependent
      Title: Drosophila heparan sulfate 6-O-endosulfatase Sulf1 facilitates wingless (Wg) protein degradation.
    3. DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop.
      Title: DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop.
    4. The results demonstrate that sulf1 is a novel Wg target gene and by a feedback mechanism, it negatively regulated Wg signaling and distribution in vivo.
      Title: Sulfated is a negative feedback regulator of wingless in Drosophila.
    5. Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation
      Title: Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine-6-sulfatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic target inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc anterior/posterior pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    sulfated
    Names
    CG6725-PA
    CG6725-PB
    CG6725-PC
    HS 6-O-sulfatase 1
    Sulf1-PA
    Sulf1-PB
    Sulf1-PC
    NP_001262626.1
    NP_001262627.1
    NP_524987.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16310542..16339575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275698.1 → NP_001262627.1  sulfated, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262627.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRG1, Q9NIH6, Q9VEX0
      UniProtKB/TrEMBL
      B7FNQ6, D1Z367
      Conserved Domains (4) summary
      COG3119
      Location:51 → 398
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      pfam12548
      Location:640 → 790
      DUF3740; Sulfatase protein
      cd16147
      Location:53 → 408
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      cl23718
      Location:940 → 989
      ALP_like; alkaline phosphatases and sulfatases

    2. NM_080248.3 → NP_524987.1  sulfated, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524987.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRG1, Q9NIH6, Q9VEX0
      UniProtKB/TrEMBL
      B7FNQ6, D1Z367
      Related
      FBpp0082725
      Conserved Domains (4) summary
      COG3119
      Location:51 → 398
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      pfam12548
      Location:640 → 790
      DUF3740; Sulfatase protein
      cd16147
      Location:53 → 408
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      cl23718
      Location:940 → 989
      ALP_like; alkaline phosphatases and sulfatases

    3. NM_001275697.1 → NP_001262626.1  sulfated, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRG1, Q9NIH6, Q9VEX0
      UniProtKB/TrEMBL
      B7FNQ6, D1Z367
      Conserved Domains (4) summary
      COG3119
      Location:51 → 398
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      pfam12548
      Location:640 → 790
      DUF3740; Sulfatase protein
      cd16147
      Location:53 → 408
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      cl23718
      Location:940 → 989
      ALP_like; alkaline phosphatases and sulfatases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D1Z367 D1Z367
    Q9VEX0.1 Q9VEX0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools