Incenp Inner centromere protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Incenpprovided by FlyBase
Official Full Name: Inner centromere proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0260991
Locus tag: Dmel_CG12165
See related: AllianceGenome:FB:FBgn0260991
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.171; CG12165; dIncenp; Dmel\CG12165; DmINCENP; incenp; INCENP; mat(2)ea-C; mat(2)earlyQA26
Summary: Enables microtubule binding activity. Involved in several processes, including chromosome organization; metaphase chromosome alignment; and spindle assembly. Located in kinetochore; meiotic spindle midzone; and mitotic spindle midzone. Part of chromosome passenger complex. Colocalizes with condensed chromosome and midbody. Orthologous to human INCENP (inner centromere protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 43A2-43A3; 2-55 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7278467..7281795)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3165972..3169300)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Incenp is necessary to stabilise the equatorial region of the metaphase I spindle, in contrast to mitosis, where the equivalent function becomes prominent after anaphase onset.
Title: Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis.
INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Title: INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
a new null allele of Incenp; Homozygous incenp(EC3747) embryos show absence of phosphorylation of histone H3 in mitosis, failure of cytokinesis and polyploidy, and defects in peripheral nervous system development
Title: Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic spindle midzone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metaphase chromosome alignment	IBA Inferred from Biological aspect of Ancestor more info
involved_in metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly involved in female meiosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
is_active_in meiotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in meiotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with midbody	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: inner centromere protein

Names: CG12165-PA; CG12165-PB; CG12165-PC; Incenp-PA; Incenp-PB; Incenp-PC; maternal effect early arrest C

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

7278467..7281795

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299227.1 → NP_001286156.1 inner centromere protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286156.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LFQ2, Q8IGP7

Conserved Domains (4) summary

pfam05672
Location:557 → 640

MAP7; MAP7 (E-MAP-115) family

pfam15814
Location:504 → 590

FAM199X; Protein family FAM199X

cd16269
Location:630 → 641

GBP_C; coiled coil [structural motif]

cl20817
Location:558 → 643

GBP_C; Guanylate-binding protein, C-terminal domain
NM_078924.5 → NP_523648.3 inner centromere protein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523648.3

Status: REVIEWED

UniProtKB/TrEMBL

Q7JRJ9, Q8IGP7

Related

FBpp0088035

Conserved Domains (4) summary

pfam05672
Location:558 → 641

MAP7; MAP7 (E-MAP-115) family

pfam15814
Location:505 → 591

FAM199X; Protein family FAM199X

cd16269
Location:631 → 642

GBP_C; coiled coil [structural motif]

cl20817
Location:559 → 644

GBP_C; Guanylate-binding protein, C-terminal domain
NM_001273833.1 → NP_001260762.1 inner centromere protein, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260762.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JRJ9, Q8IGP7

Conserved Domains (4) summary

pfam05672
Location:558 → 641

MAP7; MAP7 (E-MAP-115) family

pfam15814
Location:505 → 591

FAM199X; Protein family FAM199X

cd16269
Location:631 → 642

GBP_C; coiled coil [structural motif]

cl20817
Location:559 → 644

GBP_C; Guanylate-binding protein, C-terminal domain