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    RhoGAP15B Rho GTPase activating protein at 15B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoGAP15Bprovided by FlyBase
    Official Full Name
    Rho GTPase activating protein at 15Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030808
    Locus tag
    Dmel_CG4937
    See related
    AllianceGenome:FB:FBgn0030808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4937; Dmel\CG4937; gap20
    Summary
    Predicted to enable GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Is expressed in leg joint and spermatozoon. Orthologous to several human genes including ARAP1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1) and ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoGAP15B in Genome Data Viewer
    Location:
    15C4-15C4; 1-56 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16943290..16956234)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16837323..16850267)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene wurst Neighboring gene uncharacterized protein Neighboring gene Ubr1 ubiquitin ligase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamics of hydraulic and contractile wave-mediated fluid transport during Drosophila oogenesis. Imran Alsous J, et al. Proc Natl Acad Sci U S A, 2021 Mar 9. PMID 33658367, Free PMC Article
    2. Distinct roles and requirements for Ras pathway signaling in visceral versus somatic muscle founder specification. Zhou Y, et al. Development, 2019 Jan 18. PMID 30630823
    3. Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila. Jackson JA, et al. Curr Biol, 2024 May 20. PMID 38688282,
    4. Analysis of endocytic pathways in Drosophila cells reveals a conserved role for GBF1 in internalization via GEECs. Gupta GD, et al. PLoS One, 2009 Aug 26. PMID 19707569, Free PMC Article
    5. Systems-wide analysis of a phosphatase knock-down by quantitative proteomics and phosphoproteomics. Hilger M, et al. Mol Cell Proteomics, 2009 Aug. PMID 19429919, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase activating protein at 15B
    Names
    CG4937-PB
    CG4937-PC
    RhoGAP15B-PB
    RhoGAP15B-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16943290..16956234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132955.4 → NP_573183.2  Rho GTPase activating protein at 15B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573183.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX92
      Conserved Domains (1) summary
      cd04385
      Location:1095 → 1277
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...

    2. NM_001042817.3 → NP_001036282.1  Rho GTPase activating protein at 15B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036282.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHR5, Q8T3K2
      Conserved Domains (1) summary
      cd04385
      Location:1053 → 1235
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KHR5 Q0KHR5
    Q8T3K2 Q8T3K2
    Q9VX92 Q9VX92

    Gene LinkOut

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