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    CarT Carcinine transporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35334, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CarTprovided by FlyBase
    Official Full Name
    Carcinine transporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032879
    Locus tag
    Dmel_CG9317
    See related
    AllianceGenome:FB:FBgn0032879
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38E.10; cart; carT; Cart; CG9317; Dmel\CG9317
    Summary
    Enables carcinine transmembrane transporter activity and neurotransmitter transmembrane transporter activity. Involved in several processes, including carcinine import across plasma membrane; detection of light stimulus involved in visual perception; and positive phototaxis. Located in axon terminus. Is expressed in adult head; eye photoreceptor cell; lamina; photoreceptor neurons; and retina. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to several human genes including SLC22A1 (solute carrier family 22 member 1); SLC22A2 (solute carrier family 22 member 2); and SLC22A23 (solute carrier family 22 member 23). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CarT in Genome Data Viewer
    Location:
    38E4-38E4; 2-54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20727151..20730282, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20727151..20730282, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45306 Neighboring gene uncharacterized protein Neighboring gene Transmembrane 9 superfamily protein member 2 Neighboring gene Female sterile (2) Ketel Neighboring gene Alpha-methylacyl-CoA racemase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Vision Depends on Carcinine Uptake by an Organic Cation Transporter. Chaturvedi R, et al. Cell Rep, 2016 Mar 8. PMID 26923590, Free PMC Article
    2. The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling. Stenesen D, et al. Elife, 2015 Dec 14. PMID 26653853, Free PMC Article
    3. LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision. Xu Y, et al. Cell Rep, 2019 Apr 30. PMID 31042461
    4. The glial sodium-potassium-2-chloride cotransporter is required for synaptic transmission in the Drosophila visual system. Stenesen D, et al. Sci Rep, 2019 Feb 21. PMID 30792494, Free PMC Article
    5. Insights into the mechanism of histamine synthesis and recycling disruption induced by exposure to CdO NPs in the fruit fly (Drosophila melanogaster). El Kholy S, et al. Environ Sci Pollut Res Int, 2023 Jul. PMID 37340164

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carcinine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neurotransmitter transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carcinine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in detection of light stimulus involved in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter uptake IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive phototaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carcinine transporter
    Names
    CG9317-PA
    CG9317-PC
    CarT-PA
    CarT-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20727151..20730282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136208.4 → NP_610052.1  carcinine transporter, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610052.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961U9, Q9VIK2
      Related
      FBpp0080925
      Conserved Domains (2) summary
      cd06174
      Location:182 → 551
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:44 → 561
      2A0119; cation transport protein

    2. NM_165340.3 → NP_724282.2  carcinine transporter, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724282.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961U9, Q9VIK2
      Conserved Domains (2) summary
      cd06174
      Location:182 → 551
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:44 → 561
      2A0119; cation transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIK2.1 Q9VIK2

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